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https://doi.org/10.1038/s41598-021-90453-7
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dc.title | A single serving of mixed spices alters gut microflora composition: a dose–response randomised trial | |
dc.contributor.author | Khine, Wei Wei Thwe | |
dc.contributor.author | Haldar, Sumanto | |
dc.contributor.author | De Loi, Shou | |
dc.contributor.author | Lee, Yuan-Kun | |
dc.date.accessioned | 2022-10-13T06:45:26Z | |
dc.date.available | 2022-10-13T06:45:26Z | |
dc.date.issued | 2021-05-28 | |
dc.identifier.citation | Khine, Wei Wei Thwe, Haldar, Sumanto, De Loi, Shou, Lee, Yuan-Kun (2021-05-28). A single serving of mixed spices alters gut microflora composition: a dose–response randomised trial. Scientific Reports 11 (1) : 11264. ScholarBank@NUS Repository. https://doi.org/10.1038/s41598-021-90453-7 | |
dc.identifier.issn | 2045-2322 | |
dc.identifier.uri | https://scholarbank.nus.edu.sg/handle/10635/233054 | |
dc.description.abstract | Short-term changes in dietary intake can induce changes in gut microbiome. While various dietary polyphenols have been shown to modulate gut microflora, the acute influence of polyphenol-rich mixed spices has not been explored in a controlled setting. We investigated the effects of a single serving of mixed spices Indian curry consumption, in two separate doses, on the gut microbiome in 15 healthy, Singaporean Chinese males, with age and BMI of 23.5 ± 2.4 years and 22.9 ± 2.2 kg/m2 respectively. We found that a low-polyphenol, no spices Dose 0 Control (D0C) meal led to an increase in Bacteroides and a decrease in Bifidobacterium. In comparison to D0C, there was significant suppression of Bacteroides (p < 0.05) and an increase in Bifidobacterium (p < 0.05) with increasing doses of curry meal Dose 1 Curry (D1C) and Dose 2 Curry (D2C) containing 6 g and 12 g mixed spices respectively. Significant correlations were also found between bacterial changes and plasma phenolic acids. No differences between treatments were observed in the alpha-diversity of the gut microflora. This study has shown that a single serving of mixed spices can significantly modify/restore certain commensal microbes, particularly in people who do not regularly consume these spices. © 2021, The Author(s). | |
dc.publisher | Nature Research | |
dc.rights | Attribution 4.0 International | |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | |
dc.source | Scopus OA2021 | |
dc.type | Article | |
dc.contributor.department | MICROBIOLOGY AND IMMUNOLOGY | |
dc.contributor.department | SURGERY | |
dc.description.doi | 10.1038/s41598-021-90453-7 | |
dc.description.sourcetitle | Scientific Reports | |
dc.description.volume | 11 | |
dc.description.issue | 1 | |
dc.description.page | 11264 | |
Appears in Collections: | Staff Publications Elements |
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