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dc.titleDynamics of the fecal microbiome and antimicrobial resistome in commercial piglets during the weaning period
dc.contributor.authorSuriyaphol, Prapat
dc.contributor.authorChiu, Jimmy Ka Ho
dc.contributor.authorYimpring, Nathamon
dc.contributor.authorTunsagool, Paiboon
dc.contributor.authorMhuantong, Wuttichai
dc.contributor.authorChuanchuen, Rungtip
dc.contributor.authorBessarab, Irina
dc.contributor.authorWilliams, Rohan B. H.
dc.contributor.authorOng, Rick Twee-Hee
dc.contributor.authorSuriyaphol, Gunnaporn
dc.identifier.citationSuriyaphol, Prapat, Chiu, Jimmy Ka Ho, Yimpring, Nathamon, Tunsagool, Paiboon, Mhuantong, Wuttichai, Chuanchuen, Rungtip, Bessarab, Irina, Williams, Rohan B. H., Ong, Rick Twee-Hee, Suriyaphol, Gunnaporn (2021-09-10). Dynamics of the fecal microbiome and antimicrobial resistome in commercial piglets during the weaning period. Scientific Reports 11 (1) : 18091. ScholarBank@NUS Repository.
dc.description.abstractThis study aimed to characterize the alteration of the fecal microbiome and antimicrobial resistance (AMR) determinants in 24 piglets at day 3 pre-weaning (D. ? 3), weaning day (D.0), days 3 (D.3) and 8 post-weaning (D.8), using whole-genome shotgun sequencing. Distinct clusters of microbiomes and AMR determinants were observed at D.8 when Prevotella (20.9%) was the major genus, whereas at D. ? 3–D.3, Alistipes (6.9–12.7%) and Bacteroides (5.2–8.5%) were the major genera. Lactobacillus and Escherichia were notably observed at D. ? 3 (1.2%) and D. ? 3–D.3 (0.2–0.4%), respectively. For AMR, a distinct cluster of AMR determinants was observed at D.8, mainly conferring resistance to macrolide–lincosamide–streptogramin (mefA), ?-lactam (cfxA6 and aci1) and phenicol (rlmN). In contrast, at D. ? 3–D.3, a high abundance of determinants with aminoglycoside (AMG) (sat, aac(6')-aph(2''), aadA and acrF), ?-lactam (fus-1, cepA and mrdA), multidrug resistance (MDR) (gadW, mdtE, emrA, evgS, tolC and mdtB), phenicol (catB4 and cmlA4), and sulfonamide patterns (sul3) was observed. Canonical correlation analysis (CCA) plot associated Escherichia coli with aac(6')-aph(2''), emrA, mdtB, catB4 and cmlA4 at D. ? 3, D.0 and/or D.3 whereas at D.8 associations between Prevotella and mefA, cfxA6 and aci1 were identified. The weaning age and diet factor played an important role in the microbial community composition. © 2021, The Author(s).
dc.publisherNature Research
dc.rightsAttribution 4.0 International
dc.sourceScopus OA2021
dc.contributor.departmentLIFE SCIENCES INSTITUTE
dc.contributor.departmentSAW SWEE HOCK SCHOOL OF PUBLIC HEALTH
dc.description.sourcetitleScientific Reports
Appears in Collections:Staff Publications

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