Please use this identifier to cite or link to this item: https://doi.org/10.1038/s41388-021-01662-3
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dc.titleVacuolin-1 inhibits endosomal trafficking and metastasis via CapZ?
dc.contributor.authorYe, Zuodong
dc.contributor.authorWang, Dawei
dc.contributor.authorLu, Yingying
dc.contributor.authorHe, Yunjiao
dc.contributor.authorYu, Jingting
dc.contributor.authorWei, Wenjie
dc.contributor.authorChen, Chang
dc.contributor.authorWang, Rui
dc.contributor.authorZhang, Liang
dc.contributor.authorZhang, Liangren
dc.contributor.authorLe, Minh T. N.
dc.contributor.authorCho, William C.
dc.contributor.authorYang, Mengsu
dc.contributor.authorZhang, Hongmin
dc.contributor.authorYue, Jianbo
dc.date.accessioned2022-10-13T01:20:08Z
dc.date.available2022-10-13T01:20:08Z
dc.date.issued2021-02-09
dc.identifier.citationYe, Zuodong, Wang, Dawei, Lu, Yingying, He, Yunjiao, Yu, Jingting, Wei, Wenjie, Chen, Chang, Wang, Rui, Zhang, Liang, Zhang, Liangren, Le, Minh T. N., Cho, William C., Yang, Mengsu, Zhang, Hongmin, Yue, Jianbo (2021-02-09). Vacuolin-1 inhibits endosomal trafficking and metastasis via CapZ?. Oncogene 40 (10) : 1775-1791. ScholarBank@NUS Repository. https://doi.org/10.1038/s41388-021-01662-3
dc.identifier.issn0950-9232
dc.identifier.urihttps://scholarbank.nus.edu.sg/handle/10635/232941
dc.description.abstractMetastasis is the fundamental cause of cancer mortality, but there are still very few anti-metastatic drugs available. Endosomal trafficking has been implicated in tumor metastasis, and we have previously found that small chemical vacuolin-1 (V1) potently inhibits autophagosome-lysosome fusion and general endosomal-lysosomal degradation. Here, we assessed the anti-metastatic activity of V1 both in vitro and in vivo. V1 significantly inhibits colony formation, migration, and invasion of various cancer cells in vitro. It also compromises the assembly-disassembly dynamics of focal adhesions (FAs) by inhibiting the recycling and degradation of integrins. In various experimental or transgenic mouse models, V1 significantly suppresses the metastasis and/or tumor growth of breast cancer or melanoma. We further identified capping protein Z? (CapZ?) as a V1 binding protein and showed that it is required for the V1-mediated inhibition of migration and metastasis of cancer cells. Collectively, our results indicate that V1 targets CapZ? to inhibit endosomal trafficking and metastasis. © 2021, The Author(s), under exclusive licence to Springer Nature Limited part of Springer Nature.
dc.publisherSpringer Nature
dc.rightsAttribution 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.sourceScopus OA2021
dc.typeArticle
dc.contributor.departmentPHARMACOLOGY
dc.description.doi10.1038/s41388-021-01662-3
dc.description.sourcetitleOncogene
dc.description.volume40
dc.description.issue10
dc.description.page1775-1791
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