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dc.titleA point prevalence survey to assess antibiotic prescribing in patients hospitalized with confirmed and suspected coronavirus disease 2019 (COVID-19)
dc.contributor.authorTan, Sock Hoon
dc.contributor.authorNg, Tat Ming
dc.contributor.authorTay, Hui Lin
dc.contributor.authorYap, Min Yi
dc.contributor.authorHeng, Shi Thong
dc.contributor.authorLoo, Audrey Yong Xin
dc.contributor.authorTeng, Christine B.
dc.contributor.authorLee, Tau Hong
dc.identifier.citationTan, Sock Hoon, Ng, Tat Ming, Tay, Hui Lin, Yap, Min Yi, Heng, Shi Thong, Loo, Audrey Yong Xin, Teng, Christine B., Lee, Tau Hong (2021-03-01). A point prevalence survey to assess antibiotic prescribing in patients hospitalized with confirmed and suspected coronavirus disease 2019 (COVID-19). Journal of Global Antimicrobial Resistance 24 : 45-47. ScholarBank@NUS Repository.
dc.description.abstractBackground: Earlier studies have reported high antibiotic use in patients hospitalised for coronavirus disease 2019 (COVID-19), resulting in concerns of increasing antimicrobial resistance with increase antibiotic use in this pandemic. Point prevalence survey (PPS) can be a quick tool to provide antibiotic prescribing information to aid antimicrobial stewardship (AMS) activities. Objectives: To describe antibiotic utilization and evaluate antibiotic appropriateness in COVID-19 patients using PPS. Methods: Adapting Global-PPS on antimicrobial use, the survey was conducted in COVID-19 wards at 2 centres in Singapore on 22 April 2020 at 0800h. Patients on systemic antibiotics were included and evaluated for antibiotic appropriateness. Results: Five hundred and seventy-seven patients were screened. Thirty-six (6.2%) patients were on antibiotics and which were started at median of 7 days (inter-quartile rate (IQR), 4, 11) from symptom onset. Fifty-one antibiotics were prescribed in these patients. Overall, co-amoxiclav (26/51, 51.0%) was the most often prescribed antibiotic. Thirty-one out of 51 (60.8%) antibiotic prescriptions were appropriate. Among 20 inappropriate prescriptions, 18 (90.0%) were initiated in patients with low likelihood of bacterial infections. Antibiotic prescriptions were more appropriate when reviewed by infectious diseases physicians (13/31 [41.9%] versus 2/20 [10.0%], p = 0.015), and if reasons for use were stated in notes (31/31 [100.0%] versus 16/20 [80.0%], p = 0.019). Conclusions: Despite low prevalence of antibiotic use among confirmed and suspected COVID-19 patients at 2 centres in Singapore, there was significant proportion of inappropriate antibiotics use where bacterial infections were unlikely. AMS teams can tailor stewardship strategies using PPS results. © 2020 The Author(s)
dc.publisherElsevier Ltd
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International
dc.sourceScopus OA2021
dc.subjectPoint prevalence survey
dc.description.sourcetitleJournal of Global Antimicrobial Resistance
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