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dc.titleValidation of self-collected buccal swab and saliva as a diagnostic tool for COVID-19
dc.contributor.authorKu, Chee Wai
dc.contributor.authorShivani, Durai
dc.contributor.authorKwan, Jacqueline Q. T.
dc.contributor.authorLoy, See Ling
dc.contributor.authorErwin, Christina
dc.contributor.authorKo, Karrie K. K.
dc.contributor.authorNg, Xiang Wen
dc.contributor.authorOon, Lynette
dc.contributor.authorThoon, Koh Cheng
dc.contributor.authorKalimuddin, Shirin
dc.contributor.authorChan, Jerry K. Y.
dc.identifier.citationKu, Chee Wai, Shivani, Durai, Kwan, Jacqueline Q. T., Loy, See Ling, Erwin, Christina, Ko, Karrie K. K., Ng, Xiang Wen, Oon, Lynette, Thoon, Koh Cheng, Kalimuddin, Shirin, Chan, Jerry K. Y. (2021-03-01). Validation of self-collected buccal swab and saliva as a diagnostic tool for COVID-19. International Journal of Infectious Diseases 104 : 255-261. ScholarBank@NUS Repository.
dc.description.abstractBackground: Effective management of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) requires large-scale testing to identify and isolate infectious carriers. Self-administered buccal swab and saliva collection are convenient, painless, and safe alternatives to the current healthcare worker (HCW)-collected nasopharyngeal swab (NPS). Methods: A cross-sectional single-centre study was conducted on 42 participants who had tested positive for SARS-CoV-2 via an NPS within the past 7 days. Real-time polymerase chain reaction (RT-PCR) was performed and cycle threshold (Ct) values were obtained for each test. The positive percent agreement (PPA), negative percent agreement (NPA), and overall agreement (OA) were calculated for the saliva samples and buccal swabs, and compared with NPS. Results: Among the 42 participants, 73.8% (31/42) tested positive by any one of the three tests. With reference to NPS, the saliva test had PPA 66.7%, NPA 91.7%, and OA 69.0%; the buccal swab had PPA 56.7%, NPA 100%, and OA 73.8%. Conclusion: Self-collected saliva tests and buccal swabs showed only moderate agreement with HCW-collected NPS. Primary screening for SARS-CoV-2 may be performed with a saliva test or buccal swab, with a negative test warranting a confirmatory NPS to avoid false-negatives, minimize discomfort, and reduce the risk of spread to the community and HCWs. © 2021 The Author(s)
dc.publisherElsevier B.V.
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International
dc.sourceScopus OA2021
dc.subjectBuccal swab
dc.subjectDiagnostic tests
dc.subjectSaliva test
dc.contributor.departmentDUKE-NUS MEDICAL SCHOOL
dc.contributor.departmentDUKE-NUS OFFICE OF ACAD & CLINICAL DEVT
dc.contributor.departmentDEAN'S OFFICE (DUKE-NUS MEDICAL SCHOOL)
dc.description.sourcetitleInternational Journal of Infectious Diseases
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