Please use this identifier to cite or link to this item:
https://doi.org/10.3390/antibiotics10030227
DC Field | Value | |
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dc.title | Synergistic effect of combination interventions for methicillin-resistant Staphylococcus aureus transmission control in nursing homes: A computation modelling evaluation with heterogeneous contact mixing | |
dc.contributor.author | Tang, Arthur | |
dc.contributor.author | Kwok, Kin On | |
dc.contributor.author | Wei, Vivian Wan In | |
dc.contributor.author | Chen, Hong | |
dc.contributor.author | Wong, Samuel Yeung Shan | |
dc.contributor.author | Tam, Wilson Wai San | |
dc.date.accessioned | 2022-10-13T01:13:48Z | |
dc.date.available | 2022-10-13T01:13:48Z | |
dc.date.issued | 2021-02-24 | |
dc.identifier.citation | Tang, Arthur, Kwok, Kin On, Wei, Vivian Wan In, Chen, Hong, Wong, Samuel Yeung Shan, Tam, Wilson Wai San (2021-02-24). Synergistic effect of combination interventions for methicillin-resistant Staphylococcus aureus transmission control in nursing homes: A computation modelling evaluation with heterogeneous contact mixing. Antibiotics 10 (3) : 1-12. ScholarBank@NUS Repository. https://doi.org/10.3390/antibiotics10030227 | |
dc.identifier.issn | 2079-6382 | |
dc.identifier.uri | https://scholarbank.nus.edu.sg/handle/10635/232830 | |
dc.description.abstract | The endemic threat of methicillin-resistant Staphylococcus aureus (MRSA) in nursing homes poses a serious and escalating challenge to public health administration in infection control. Nursing homes are considered as major reservoirs for MRSA colonization, with considerable high levels of colonization prevalence. We employed a computation model to evaluate effects of three intervention scenarios on MRSA colonization prevalence rate in nursing homes. Simulations were conducted using a deterministic compartmental model featuring heterogeneous contact matrix between residents and health-care workers (HCWs). Contact parameters were derived from a nursing home survey. Three intervention scenarios were simulated: (1) hand-hygiene compliance by HCWs, (2) screening-and-isolation upon admission, and (3) implementing both interventions at the same time. For every 10% reduction in average contamination duration in HCWs, the estimated average reduction in prevalence rate was 1.29 percentage point compared with the prevalence rate before the intervention was implemented. Screening-and-isolation intervention resulted in an average reduction of 19.04 percentage point in prevalence rate (S.D. = 1.58; 95% CI = 18.90-19.18). In intervention scenario 3, synergistic effects were observed when implementing hand-hygiene compliance by HCWs and screening-and-isolation together. Our results provide evidence showing that implementing multiple interventions together has a synergistic effect on colonization prevalence reduction. © 2021 by the authors. Licensee MDPI, Basel, Switzerland. | |
dc.publisher | MDPI AG | |
dc.rights | Attribution 4.0 International | |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | |
dc.source | Scopus OA2021 | |
dc.subject | Antimicrobial resistance | |
dc.subject | Interventions | |
dc.subject | Methicillin-resistant staphylococcus aureus transmission | |
dc.subject | Nursing home | |
dc.subject | Simulation and modelling | |
dc.subject | Synergistic effect | |
dc.type | Article | |
dc.contributor.department | ALICE LEE CENTRE FOR NURSING STUDIES | |
dc.description.doi | 10.3390/antibiotics10030227 | |
dc.description.sourcetitle | Antibiotics | |
dc.description.volume | 10 | |
dc.description.issue | 3 | |
dc.description.page | 1-12 | |
Appears in Collections: | Elements Staff Publications |
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