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Please use this identifier to cite or link to this item: https://doi.org/10.1038/s41467-020-20851-4
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dc.titleGenome-wide meta-analysis identifies 127 open-angle glaucoma loci with consistent effect across ancestries
dc.contributor.authorGharahkhani, Puya
dc.contributor.authorJorgenson, Eric
dc.contributor.authorHysi, Pirro
dc.contributor.authorKhawaja, Anthony P.
dc.contributor.authorPendergrass, Sarah
dc.contributor.authorHan, Xikun
dc.contributor.authorOng, Jue Sheng
dc.contributor.authorHewitt, Alex W.
dc.contributor.authorSegrè, A.V.
dc.contributor.authorRouhana, John M.
dc.contributor.authorHamel, Andrew R.
dc.contributor.authorIgo, Robert P., Jr.
dc.contributor.authorChoquet, Helene
dc.contributor.authorQassim, Ayub
dc.contributor.authorJosyula, Navya S.
dc.contributor.authorCooke Bailey, J.N.
dc.contributor.authorBonnemaijer, Pieter W. M.
dc.contributor.authorIglesias, Adriana
dc.contributor.authorSiggs, Owen M.
dc.contributor.authorYoung, Terri L.
dc.contributor.authorVitart, Veronique
dc.contributor.authorThiadens, Alberta A. H. J.
dc.contributor.authorKarjalainen, Juha
dc.contributor.authorUebe, Steffen
dc.contributor.authorMelles, Ronald B.
dc.contributor.authorNair, K. Saidas
dc.contributor.authorLuben, Robert
dc.contributor.authorSimcoe, Mark
dc.contributor.authorAmersinghe, Nishani
dc.contributor.authorCree, Angela J.
dc.contributor.authorHohn, Rene
dc.contributor.authorPoplawski, Alicia
dc.contributor.authorChen, Li Jia
dc.contributor.authorRong, Shi-Song
dc.contributor.authorAung, Tin
dc.contributor.authorVithana, Eranga Nishanthie
dc.contributor.authorAllingham, R.R.
dc.contributor.authorBrilliant, M.
dc.contributor.authorBudenz, D.L.
dc.contributor.authorBailey, Jessica N. Cooke
dc.contributor.authorFingert, J.H.
dc.contributor.authorGaasterland, D.
dc.contributor.authorGaasterland, T.
dc.contributor.authorHaines, Jonathan L.
dc.contributor.authorHauser, Michael
dc.contributor.authorLee, R.K.
dc.contributor.authorLichter, P.R.
dc.contributor.authorLiu, Y.
dc.contributor.authorMoroi, S.
dc.contributor.authorMyers, J.
dc.contributor.authorPericak-Vance, M.
dc.contributor.authorRealini, A.
dc.contributor.authorRhee, D.
dc.contributor.authorRichards, J.E.
dc.contributor.authorRitch, R.
dc.contributor.authorSchuman, J.S.
dc.contributor.authorScott, W.K.
dc.contributor.authorSingh, K.
dc.contributor.authorSit, A.J.
dc.contributor.authorVollrath, D.
dc.contributor.authorWeinreb, R.N.
dc.contributor.authorWollstein, G.
dc.contributor.authorZack, D.J.
dc.contributor.authorSharma, S.
dc.contributor.authorMartin, S.
dc.contributor.authorZhou, T.
dc.contributor.authorSouzeau, E.
dc.contributor.authorLanders, J.
dc.contributor.authorFitzgerald, J.T.
dc.contributor.authorMills, R.A.
dc.contributor.authorCraig, Jamie E.
dc.contributor.authorBurdon, K.
dc.contributor.authorGraham, S.L.
dc.contributor.authorCasson, R.J.
dc.contributor.authorGoldberg, I.
dc.contributor.authorWhite, A.J.
dc.contributor.authorHealey, P.R.
dc.contributor.authorMackey, David A.
dc.contributor.authorHewitt, Alex W.
dc.contributor.authorShiono, M.
dc.contributor.authorMisumi, K.
dc.contributor.authorKaieda, R.
dc.contributor.authorHarada, H.
dc.contributor.authorMinami, S.
dc.contributor.authorEmi, M.
dc.contributor.authorEmoto, N.
dc.contributor.authorDaida, H.
dc.contributor.authorMiyauchi, K.
dc.contributor.authorMurakami, A.
dc.contributor.authorAsai, S.
dc.contributor.authorMoriyama, M.
dc.contributor.authorTakahashi, Y.
dc.contributor.authorFujioka, T.
dc.contributor.authorObara, W.
dc.contributor.authorMori, S.
dc.contributor.authorIto, H.
dc.contributor.authorNagayama, S.
dc.contributor.authorMiki, Y.
dc.contributor.authorMasumoto, A.
dc.contributor.authorYamada, A.
dc.contributor.authorNishizawa, Y.
dc.contributor.authorKodama, K.
dc.contributor.authorKutsumi, H.
dc.contributor.authorSugimoto, Y.
dc.contributor.authorKoretsune, Y.
dc.contributor.authorKusuoka, H.
dc.contributor.authorYanaiag, H.
dc.contributor.authorNagai, A.
dc.contributor.authorHirata, M.
dc.contributor.authorKamatani, Yoichiro
dc.contributor.authorMuto, K.
dc.contributor.authorMatsuda, K.
dc.contributor.authorKiyohara, Y.
dc.contributor.authorNinomiya, T.
dc.contributor.authorTamakoshi, A.
dc.contributor.authorYamagata, Z.
dc.contributor.authorMushiroda, T.
dc.contributor.authorMurakami, Y.
dc.contributor.authorYuji, K.
dc.contributor.authorFurukawa, Y.
dc.contributor.authorZembutsu, H.
dc.contributor.authorTanaka, T.
dc.contributor.authorOhnishi, Y.
dc.contributor.authorNakamura, Y.
dc.contributor.authorJalanko, A.
dc.contributor.authorKaprio, J.
dc.contributor.authorDonner, K.
dc.contributor.authorKaunisto, M.
dc.contributor.authorMars, N.
dc.contributor.authorDada, A.
dc.contributor.authorShcherban, A.
dc.contributor.authorGanna, A.
dc.contributor.authorLehisto, A.
dc.contributor.authorKilpeläinen, E.
dc.contributor.authorBrein, G.
dc.contributor.authorAwaisa, G.
dc.contributor.authorHarju, J.
dc.contributor.authorPärn, K.
dc.contributor.authorDella Briotta Parolo, P.
dc.contributor.authorKajanne, R.
dc.contributor.authorLemmelä, S.
dc.contributor.authorSipilä, T.P.
dc.contributor.authorSipilä, T.
dc.contributor.authorLyhs, U.
dc.contributor.authorLlorens, V.
dc.contributor.authorNiiranen, T.
dc.contributor.authorKristiansson, K.
dc.contributor.authorMännikkö, L.
dc.contributor.authorJiménez, M.G.
dc.contributor.authorPerola, M.
dc.contributor.authorWong, R.
dc.contributor.authorKilpi, T.
dc.contributor.authorHiekkalinna, T.
dc.contributor.authorJärvensivu, E.
dc.contributor.authorKaiharju, E.
dc.contributor.authorMattsson, H.
dc.contributor.authorLaukkanen, M.
dc.contributor.authorLaiho, P.
dc.contributor.authorLähteenmäki, S.
dc.contributor.authorSistonen, T.
dc.contributor.authorSoini, S.
dc.contributor.authorZiemann, A.
dc.contributor.authorLehtonen, A.
dc.contributor.authorLertratanakul, A.
dc.contributor.authorGeorgantas, B.
dc.contributor.authorRiley-Gillis, B.
dc.contributor.authorQuarless, D.
dc.contributor.authorRahimov, F.
dc.contributor.authorHeap, G.
dc.contributor.authorJacob, H.
dc.contributor.authorWaring, J.
dc.contributor.authorDavis, J.W.
dc.contributor.authorSmaoui, N.
dc.contributor.authorPopovic, R.
dc.contributor.authorEsmaeeli, S.
dc.contributor.authorWaring, J.
dc.contributor.authorMatakidou, A.
dc.contributor.authorChallis, B.
dc.contributor.authorClose, D.
dc.contributor.authorPetrovski, S.
dc.contributor.authorKarlsson, A.
dc.contributor.authorSchleutker, J.
dc.contributor.authorPulkki, K.
dc.contributor.authorVirolainen, P.
dc.contributor.authorKallio, L.
dc.contributor.authorMannermaa, A.
dc.contributor.authorHeikkinen, S.
dc.contributor.authorKosma, V.-M.
dc.contributor.authorChen, C.-Y.
dc.contributor.authorRunz, H.
dc.contributor.authorLiu, J.
dc.contributor.authorBronson, P.
dc.contributor.authorJohn, S.
dc.contributor.authorLahdenperä, S.
dc.contributor.authorEaton, S.
dc.contributor.authorZhou, W.
dc.contributor.authorHendolin, M.
dc.contributor.authorTuovila, O.
dc.contributor.authorPakkanen, R.
dc.contributor.authorMaranville, J.
dc.contributor.authorUsiskin, K.
dc.contributor.authorHochfeld, M.
dc.contributor.authorPlenge, R.
dc.contributor.authorYang, R.
dc.contributor.authorBiswas, S.
dc.contributor.authorGreenberg, S.
dc.contributor.authorLaakkonen, E.
dc.contributor.authorKononen, J.
dc.contributor.authorPaloneva, J.
dc.contributor.authorKujala, U.
dc.contributor.authorKuopio, T.
dc.contributor.authorLaukkanen, J.
dc.contributor.authorKangasniemi, E.
dc.contributor.authorSavinainen, K.
dc.contributor.authorLaaksonen, R.
dc.contributor.authorArvas, M.
dc.contributor.authorRitari, J.
dc.contributor.authorPartanen, J.
dc.contributor.authorHyvärinen, K.
dc.contributor.authorWahlfors, T.
dc.contributor.authorPeterson, A.
dc.contributor.authorOh, D.
dc.contributor.authorChang, D.
dc.contributor.authorTeng, E.
dc.contributor.authorStrauss, E.
dc.contributor.authorKerchner, G.
dc.contributor.authorChen, H.
dc.contributor.authorChen, H.
dc.contributor.authorSchutzman, J.
dc.contributor.authorMichon, J.
dc.contributor.authorHunkapiller, J.
dc.contributor.authorMcCarthy, M.
dc.contributor.authorBowers, N.
dc.contributor.authorLu, T.
dc.contributor.authorBhangale, T.
dc.contributor.authorPulford, D.
dc.contributor.authorWaterworth, D.
dc.contributor.authorKulkarni, D.
dc.contributor.authorXu, F.
dc.contributor.authorBetts, J.
dc.contributor.authorGordillo, J.E.
dc.contributor.authorHoffman, J.
dc.contributor.authorAuro, K.
dc.contributor.authorMcCarthy, L.
dc.contributor.authorGhosh, S.
dc.contributor.authorEhm, M.
dc.contributor.authorPitkänen, K.
dc.contributor.authorMäkelä, T.
dc.contributor.authorLoukola, A.
dc.contributor.authorJoensuu, H.
dc.contributor.authorSinisalo, J.
dc.contributor.authorEklund, K.
dc.contributor.authorAaltonen, L.
dc.contributor.authorFärkkilä, M.
dc.contributor.authorCarpen, O.
dc.contributor.authorKauppi, P.
dc.contributor.authorTienari, P.
dc.contributor.authorOllila, T.
dc.contributor.authorTuomi, T.
dc.contributor.authorMeretoja, T.
dc.contributor.authorPitkäranta, A.
dc.contributor.authorTurunen, J.
dc.contributor.authorHannula-Jouppi, K.
dc.contributor.authorPikkarainen, S.
dc.contributor.authorSeitsonen, S.
dc.contributor.authorKoskinen, M.
dc.contributor.authorPalomäki, A.
dc.contributor.authorRinne, J.
dc.contributor.authorMetsärinne, K.
dc.contributor.authorElenius, K.
dc.contributor.authorPirilä, L.
dc.contributor.authorKoulu, L.
dc.contributor.authorVoutilainen, M.
dc.contributor.authorJuonala, M.
dc.contributor.authorPeltonen, S.
dc.contributor.authorAaltonen, V.
dc.contributor.authorLoboda, A.
dc.contributor.authorPodgornaia, A.
dc.contributor.authorChhibber, A.
dc.contributor.authorChu, A.
dc.contributor.authorFox, C.
dc.contributor.authorDiogo, D.
dc.contributor.authorHolzinger, E.
dc.contributor.authorEicher, J.
dc.contributor.authorGormley, P.
dc.contributor.authorMehta, V.
dc.contributor.authorWang, Xin
dc.contributor.authorKettunen, J.
dc.contributor.authorPylkäs, K.
dc.contributor.authorKalaoja, M.
dc.contributor.authorKarjalainen, M.
dc.contributor.authorHinttala, R.
dc.contributor.authorKaarteenaho, R.
dc.contributor.authorVainio, S.
dc.contributor.authorMantere, T.
dc.contributor.authorRemes, A.
dc.contributor.authorHuhtakangas, J.
dc.contributor.authorJunttila, J.
dc.contributor.authorTasanen, K.
dc.contributor.authorHuilaja, L.
dc.contributor.authorLuodonpää, M.
dc.contributor.authorHautala, N.
dc.contributor.authorKarihtala, P.
dc.contributor.authorKauppila, S.
dc.contributor.authorHarju, T.
dc.contributor.authorBlomster, T.
dc.contributor.authorSoininen, H.
dc.contributor.authorHarvima, I.
dc.contributor.authorPihlajamäki, J.
dc.contributor.authorKaarniranta, K.
dc.contributor.authorPelkonen, M.
dc.contributor.authorLaakso, M.
dc.contributor.authorHiltunen, M.
dc.contributor.authorKiviniemi, M.
dc.contributor.authorKaipiainen-Seppänen, O.
dc.contributor.authorAuvinen, P.
dc.contributor.authorKälviäinen, R.
dc.contributor.authorJulkunen, V.
dc.contributor.authorMalarstig, A.
dc.contributor.authorHedman, Å.
dc.contributor.authorMarshall, C.
dc.contributor.authorWhelan, C.
dc.contributor.authorLehtonen, H.
dc.contributor.authorParkkinen, J.
dc.contributor.authorLinden, K.
dc.contributor.authorKalpala, K.
dc.contributor.authorMiller, M.
dc.contributor.authorBing, N.
dc.contributor.authorMcDonough, S.
dc.contributor.authorChen, X.
dc.contributor.authorHu, X.
dc.contributor.authorWu, Y.
dc.contributor.authorAuranen, A.
dc.contributor.authorJussila, A.
dc.contributor.authorUusitalo-Järvinen, H.
dc.contributor.authorKankaanranta, H.
dc.contributor.authorUusitalo, H.
dc.contributor.authorPeltola, J.
dc.contributor.authorKähönen, M.
dc.contributor.authorIsomäki, P.
dc.contributor.authorLaitinen, T.
dc.contributor.authorSalmi, T.
dc.contributor.authorMuslin, A.
dc.contributor.authorWang, C.
dc.contributor.authorChatelain, C.
dc.contributor.authorXu, E.
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dc.contributor.authorChakravarthy, U.
dc.contributor.authorChan, M.
dc.contributor.authorCipriani, V.
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dc.contributor.authorDick, A.
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dc.contributor.authorFoster, Paul J.
dc.contributor.authorFruttiger, M.
dc.contributor.authorGallacher, J.
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dc.contributor.authorGuggenheim, J.
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dc.contributor.authorHarding, S.
dc.contributor.authorHogg, R.
dc.contributor.authorKeane, P.A.
dc.contributor.authorKhaw, Peng T.
dc.contributor.authorKhawaja, Anthony P.
dc.contributor.authorLascaratos, G.
dc.contributor.authorLotery, Andrew J.
dc.contributor.authorLuthert, P.
dc.contributor.authorMacgillivray, T.
dc.contributor.authorMackie, S.
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dc.contributor.authorMckibbin, M.
dc.contributor.authorMitry, D.
dc.contributor.authorMoore, T.
dc.contributor.authorMorgan, James E.
dc.contributor.authorMuthy, Z.
dc.contributor.authorO’Sullivan, E.
dc.contributor.authorOwen, C.
dc.contributor.authorPatel, P.
dc.contributor.authorPaterson, E.
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dc.contributor.authorPetzold, A.
dc.contributor.authorRahi, J.
dc.contributor.authorRudnicka, A.
dc.contributor.authorSelf, J.
dc.contributor.authorSivaprasad, S.
dc.contributor.authorSteel, D.
dc.contributor.authorStratton, I.
dc.contributor.authorStrouthidis, Nicholas G.
dc.contributor.authorSudlow, C.
dc.contributor.authorThaung, C.
dc.contributor.authorThomas, D.
dc.contributor.authorTrucco, E.
dc.contributor.authorTufail, A.
dc.contributor.authorVernon, S.
dc.contributor.authorViswanathan, A.
dc.contributor.authorWilliams, C.
dc.contributor.authorWilliams, K.
dc.contributor.authorWoodside, J.
dc.contributor.authorYates, M.
dc.contributor.authorYip, J.
dc.contributor.authorZheng, Y.
dc.contributor.authorTapp, R.
dc.contributor.authorAtan, D.
dc.contributor.authorDoney, A.
dc.contributor.authorallen, N.
dc.contributor.authorLittlejohns, T.
dc.contributor.authorSergouniotis, P.
dc.contributor.authorBlack, G.
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dc.contributor.authorNtomoka, C.
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dc.contributor.authorBryc, K.
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dc.contributor.authorGandhi, P.M.
dc.contributor.authorHeilbron, K.
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dc.contributor.authorHuber, K.E.
dc.contributor.authorJewett, E.M.
dc.contributor.authorJiang, Y.
dc.contributor.authorKleinman, A.
dc.contributor.authorLin, K.-H.
dc.contributor.authorLitterman, N.K.
dc.contributor.authorMcCreight, J.C.
dc.contributor.authorMcIntyre, M.H.
dc.contributor.authorMcManus, K.F.
dc.contributor.authorMountain, J.L.
dc.contributor.authorMozaffari, S.V.
dc.contributor.authorNandakumar, P.
dc.contributor.authorNoblin, E.S.
dc.contributor.authorNorthover, C.A.M.
dc.contributor.authorO’Connell, J.
dc.contributor.authorPitts, S.J.
dc.contributor.authorPoznik, G.D.
dc.contributor.authorSathirapongsasuti, J.F.
dc.contributor.authorShastri, A.J.
dc.contributor.authorShelton, J.F.
dc.contributor.authorShringarpure, S.
dc.contributor.authorTian, C.
dc.contributor.authorTung, J.Y.
dc.contributor.authorTunney, R.J.
dc.contributor.authorVacic, V.
dc.contributor.authorZare, A.S.
dc.contributor.authorTamiya, Gen
dc.contributor.authorShiga, Yukihiro
dc.contributor.authorYamamoto, Masayuki
dc.contributor.authorNakazawa, Toru
dc.contributor.authorCurrant, Hannah
dc.contributor.authorBirney, Ewan
dc.contributor.authorWang, Xin
dc.contributor.authorAuton, Adam
dc.contributor.authorLupton, Michelle K.
dc.contributor.authorMartin, Nicholas G.
dc.contributor.authorAshaye, Adeyinka
dc.contributor.authorOlawoye, Olusola
dc.contributor.authorWilliams, Susan E.
dc.contributor.authorAkafo, Stephen
dc.contributor.authorRamsay, Michele
dc.contributor.authorHashimoto, Kazuki
dc.contributor.authorKamatani, Yoichiro
dc.contributor.authorAkiyama, Masato
dc.contributor.authorMomozawa, Yukihide
dc.contributor.authorFoster, Paul J.
dc.contributor.authorKhaw, Peng T.
dc.contributor.authorMorgan, James E.
dc.contributor.authorStrouthidis, Nicholas G.
dc.contributor.authorKraft, Peter
dc.contributor.authorKang, Jae H.
dc.contributor.authorPang, Chi Pui
dc.contributor.authorPasutto, Francesca
dc.contributor.authorMitchell, Paul
dc.contributor.authorLotery, Andrew J.
dc.contributor.authorPalotie, Aarno
dc.contributor.authorVan Duijn, Cornelia
dc.contributor.authorHammond, Chris
dc.contributor.authorPasquale, Louis R.
dc.contributor.authorKlaver, Caroline C. W.
dc.contributor.authorKlaver, Caroline C. W.
dc.contributor.authorHauser, Michael
dc.contributor.authorCheng, Ching-Yu
dc.contributor.authorMacgregor, Stuart
dc.contributor.authorWiggs, Janey L.
dc.date.accessioned2022-10-13T01:08:58Z
dc.date.available2022-10-13T01:08:58Z
dc.date.issued2021-02-24
dc.identifier.citationGharahkhani, Puya, Jorgenson, Eric, Hysi, Pirro, Khawaja, Anthony P., Pendergrass, Sarah, Han, Xikun, Ong, Jue Sheng, Hewitt, Alex W., Segrè, A.V., Rouhana, John M., Hamel, Andrew R., Igo, Robert P., Jr., Choquet, Helene, Qassim, Ayub, Josyula, Navya S., Cooke Bailey, J.N., Bonnemaijer, Pieter W. M., Iglesias, Adriana, Siggs, Owen M., Young, Terri L., Vitart, Veronique, Thiadens, Alberta A. H. J., Karjalainen, Juha, Uebe, Steffen, Melles, Ronald B., Nair, K. Saidas, Luben, Robert, Simcoe, Mark, Amersinghe, Nishani, Cree, Angela J., Hohn, Rene, Poplawski, Alicia, Chen, Li Jia, Rong, Shi-Song, Aung, Tin, Vithana, Eranga Nishanthie, Allingham, R.R., Brilliant, M., Budenz, D.L., Bailey, Jessica N. 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Akafo, Stephen, Ramsay, Michele, Hashimoto, Kazuki, Kamatani, Yoichiro, Akiyama, Masato, Momozawa, Yukihide, Foster, Paul J., Khaw, Peng T., Morgan, James E., Strouthidis, Nicholas G., Kraft, Peter, Kang, Jae H., Pang, Chi Pui, Pasutto, Francesca, Mitchell, Paul, Lotery, Andrew J., Palotie, Aarno, Van Duijn, Cornelia, Hammond, Chris, Pasquale, Louis R., Klaver, Caroline C. W., Klaver, Caroline C. W., Hauser, Michael, Cheng, Ching-Yu, Macgregor, Stuart, Wiggs, Janey L. (2021-02-24). Genome-wide meta-analysis identifies 127 open-angle glaucoma loci with consistent effect across ancestries. Nature Communications 12 (1) : 1258. ScholarBank@NUS Repository. https://doi.org/10.1038/s41467-020-20851-4
dc.identifier.issn2041-1723
dc.identifier.urihttps://scholarbank.nus.edu.sg/handle/10635/232760
dc.description.abstractPrimary open-angle glaucoma (POAG), is a heritable common cause of blindness world-wide. To identify risk loci, we conduct a large multi-ethnic meta-analysis of genome-wide association studies on a total of 34,179 cases and 349,321 controls, identifying 44 previously unreported risk loci and confirming 83 loci that were previously known. The majority of loci have broadly consistent effects across European, Asian and African ancestries. Cross-ancestry data improve fine-mapping of causal variants for several loci. Integration of multiple lines of genetic evidence support the functional relevance of the identified POAG risk loci and highlight potential contributions of several genes to POAG pathogenesis, including SVEP1, RERE, VCAM1, ZNF638, CLIC5, SLC2A12, YAP1, MXRA5, and SMAD6. Several drug compounds targeting POAG risk genes may be potential glaucoma therapeutic candidates. © 2021, The Author(s).
dc.publisherNature Research
dc.rightsAttribution 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.sourceScopus OA2021
dc.typeArticle
dc.contributor.departmentDUKE-NUS MEDICAL SCHOOL
dc.description.doi10.1038/s41467-020-20851-4
dc.description.sourcetitleNature Communications
dc.description.volume12
dc.description.issue1
dc.description.page1258
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