Please use this identifier to cite or link to this item: https://doi.org/10.1186/s13613-021-00957-8
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dc.titleImpact of the COVID-19 pandemic on the epidemiology of out-of-hospital cardiac arrest: a systematic review and meta-analysis
dc.contributor.authorTeoh, Seth En
dc.contributor.authorMasuda, Yoshio
dc.contributor.authorTan, Darren Jun Hao
dc.contributor.authorLiu, Nan
dc.contributor.authorMorrison, Laurie J.
dc.contributor.authorOng, Marcus Eng Hock
dc.contributor.authorBlewer, Audrey L.
dc.contributor.authorHo, Andrew Fu Wah
dc.date.accessioned2022-10-13T01:04:30Z
dc.date.available2022-10-13T01:04:30Z
dc.date.issued2021-12-01
dc.identifier.citationTeoh, Seth En, Masuda, Yoshio, Tan, Darren Jun Hao, Liu, Nan, Morrison, Laurie J., Ong, Marcus Eng Hock, Blewer, Audrey L., Ho, Andrew Fu Wah (2021-12-01). Impact of the COVID-19 pandemic on the epidemiology of out-of-hospital cardiac arrest: a systematic review and meta-analysis. Annals of Intensive Care 11 (1) : 169. ScholarBank@NUS Repository. https://doi.org/10.1186/s13613-021-00957-8
dc.identifier.issn2110-5820
dc.identifier.urihttps://scholarbank.nus.edu.sg/handle/10635/232688
dc.description.abstractBackground: The coronavirus disease 2019 (COVID-19) pandemic has significantly influenced epidemiology, yet its impact on out-of-hospital cardiac arrest (OHCA) remains unclear. We aimed to evaluate the impact of the pandemic on the incidence and case fatality rate (CFR) of OHCA. We also evaluated the impact on intermediate outcomes and clinical characteristics. Methods: PubMed, EMBASE, Web of Science, Scopus, and Cochrane Library databases were searched from inception to May 3, 2021. Studies were included if they compared OHCA processes and outcomes between the pandemic and historical control time periods. Meta-analyses were performed for primary outcomes [annual incidence, mortality, and case fatality rate (CFR)], secondary outcomes [field termination of resuscitation (TOR), return of spontaneous circulation (ROSC), survival to hospital admission, and survival to hospital discharge], and clinical characteristics (shockable rhythm and etiologies). This study was registered in the International Prospective Register of Systematic Reviews (PROSPERO) (CRD42021253879). Results: The COVID-19 pandemic was associated with a 39.5% increase in pooled annual OHCA incidence (p < 0.001). Pooled CFR was increased by 2.65% (p < 0.001), with a pooled odds ratio (OR) of 1.95 for mortality [95% confidence interval (95%CI) 1.51–2.51]. There was increased field TOR (OR = 2.46, 95%CI 1.62–3.74). There were decreased ROSC (OR = 0.65, 95%CI 0.55–0.77), survival to hospital admission (OR = 0.65, 95%CI 0.48–0.89), and survival to discharge (OR = 0.52, 95%CI 0.40–0.69). There was decreased shockable rhythm (OR = 0.73, 95%CI 0.60–0.88) and increased asphyxial etiology of OHCA (OR = 1.17, 95%CI 1.02–1.33). Conclusion: Compared to the pre-pandemic period, the COVID-19 pandemic period was significantly associated with increased OHCA incidence and worse outcomes. © 2021, The Author(s).
dc.publisherSpringer Science and Business Media Deutschland GmbH
dc.rightsAttribution 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.sourceScopus OA2021
dc.subjectAmbulance
dc.subjectCardiac arrest
dc.subjectCoronavirus
dc.subjectCOVID-19
dc.subjectEmergency medical services
dc.subjectEpidemiology
dc.subjectOHCA
dc.subjectOut of hospital
dc.subjectPandemic
dc.subjectResuscitation
dc.subjectSudden cardiac death
dc.typeArticle
dc.contributor.departmentDUKE-NUS MEDICAL SCHOOL
dc.contributor.departmentDEAN'S OFFICE (DUKE-NUS MEDICAL SCHOOL)
dc.description.doi10.1186/s13613-021-00957-8
dc.description.sourcetitleAnnals of Intensive Care
dc.description.volume11
dc.description.issue1
dc.description.page169
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