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https://doi.org/10.1016/j.envint.2020.105975
Title: | Sub-multiplicative interaction between polygenic risk score and household coal use in relation to lung adenocarcinoma among never-smoking women in Asia | Authors: | Blechter, Batel Wong, Jason Y. Y. Agnes Hsiung, C. Hosgood, H. Dean Yin, Zhihua Shu, Xiao-Ou Zhang, Han Shi, Jianxin Song, Lei Song, Minsun Zheng, Wei Wang, Zhaoming Caporaso, Neil Burdette, Laurie Yeager, Meredith Berndt, Sonja I. Teresa Landi, M. Chen, Chien-Jen Chang, Gee-Chen Hsiao, Chin-Fu Tsai, Ying-Huang Chen, Kuan-Yu Huang, Ming-Shyan Su, Wu-Chou Chen, Yuh-Min Chien, Li-Hsin Chen, Chung-Hsing Yang, Tsung-Ying Wang, Chih-Liang Hung, Jen-Yu Lin, Chien-Chung Perng, Reury-Perng Chen, Chih-Yi Chen, Kun-Chieh Li, Yao-Jen Yu, Chong-Jen Chen, Yi-Song Chen, Ying-Hsiang Tsai, Fang-Yu Seow Wei Jie Bassig, Bryan A. Hu, Wei Ji, Bu-Tian Wu, Wei Guan, Peng He, Qincheng Gao, Yu-Tang Cai, Qiuyin Chow, Wong-Ho Xiang, Yong-Bing Lin, Dongxin Wu, Chen Wu, Yi-Long Shin, Min-Ho Hong, Yun-Chul Matsuo, Keitaro Chen, Kexin Pik Wong, M. Lu, Daru Jin, Li Wang, Jiu-Cun Seow, Adeline Wu, Tangchun Shen, Hongbing Fraumeni, Joseph F. Yang, Pan-Chyr Chang, I-Shou Zhou, Baosen Chanock, Stephen J. Rothman, Nathaniel Chatterjee, Nilanjan Lan, Qing |
Keywords: | Gene-environment interaction Household coal use Lung adenocarcinoma Never-smoking women in Asia Polygenic risk score |
Issue Date: | 1-Feb-2021 | Publisher: | Elsevier Ltd | Citation: | Blechter, Batel, Wong, Jason Y. Y., Agnes Hsiung, C., Hosgood, H. Dean, Yin, Zhihua, Shu, Xiao-Ou, Zhang, Han, Shi, Jianxin, Song, Lei, Song, Minsun, Zheng, Wei, Wang, Zhaoming, Caporaso, Neil, Burdette, Laurie, Yeager, Meredith, Berndt, Sonja I., Teresa Landi, M., Chen, Chien-Jen, Chang, Gee-Chen, Hsiao, Chin-Fu, Tsai, Ying-Huang, Chen, Kuan-Yu, Huang, Ming-Shyan, Su, Wu-Chou, Chen, Yuh-Min, Chien, Li-Hsin, Chen, Chung-Hsing, Yang, Tsung-Ying, Wang, Chih-Liang, Hung, Jen-Yu, Lin, Chien-Chung, Perng, Reury-Perng, Chen, Chih-Yi, Chen, Kun-Chieh, Li, Yao-Jen, Yu, Chong-Jen, Chen, Yi-Song, Chen, Ying-Hsiang, Tsai, Fang-Yu, Seow Wei Jie, Bassig, Bryan A., Hu, Wei, Ji, Bu-Tian, Wu, Wei, Guan, Peng, He, Qincheng, Gao, Yu-Tang, Cai, Qiuyin, Chow, Wong-Ho, Xiang, Yong-Bing, Lin, Dongxin, Wu, Chen, Wu, Yi-Long, Shin, Min-Ho, Hong, Yun-Chul, Matsuo, Keitaro, Chen, Kexin, Pik Wong, M., Lu, Daru, Jin, Li, Wang, Jiu-Cun, Seow, Adeline, Wu, Tangchun, Shen, Hongbing, Fraumeni, Joseph F., Yang, Pan-Chyr, Chang, I-Shou, Zhou, Baosen, Chanock, Stephen J., Rothman, Nathaniel, Chatterjee, Nilanjan, Lan, Qing (2021-02-01). Sub-multiplicative interaction between polygenic risk score and household coal use in relation to lung adenocarcinoma among never-smoking women in Asia. Environment International 147 : 105975. ScholarBank@NUS Repository. https://doi.org/10.1016/j.envint.2020.105975 | Rights: | Attribution-NonCommercial-NoDerivatives 4.0 International | Abstract: | We previously identified 10 lung adenocarcinoma susceptibility loci in a genome-wide association study (GWAS) conducted in the Female Lung Cancer Consortium in Asia (FLCCA), the largest genomic study of lung cancer among never-smoking women to date. Furthermore, household coal use for cooking and heating has been linked to lung cancer in Asia, especially in Xuanwei, China. We investigated the potential interaction between genetic susceptibility and coal use in FLCCA. We analyzed GWAS-data from Taiwan, Shanghai, and Shenyang (1472 cases; 1497 controls), as well as a separate study conducted in Xuanwei (152 cases; 522 controls) for additional analyses. We summarized genetic susceptibility using a polygenic risk score (PRS), which was the weighted sum of the risk-alleles from the 10 previously identified loci. We estimated associations between a PRS, coal use (ever/never), and lung adenocarcinoma with multivariable logistic regression models, and evaluated potential gene-environment interactions using likelihood ratio tests. There was a strong association between continuous PRS and lung adenocarcinoma among never coal users (Odds Ratio (OR) = 1.69 (95% Confidence Interval (CI) = 1.53, 1.87), p=1 × 10?26). This effect was attenuated among ever coal users (OR = 1.24 (95% CI: 1.03, 1.50), p = 0.02, p-interaction = 6 × 10?3). We observed similar attenuation among coal users from Xuanwei. Our study provides evidence that genetic susceptibility to lung adenocarcinoma among never-smoking Asian women is weaker among coal users. These results suggest that lung cancer pathogenesis may differ, at least partially, depending on exposure to coal combustion products. Notably, these novel findings are among the few instances of sub-multiplicative gene-environment interactions in the cancer literature. © 2020 The Authors | Source Title: | Environment International | URI: | https://scholarbank.nus.edu.sg/handle/10635/232526 | ISSN: | 0160-4120 | DOI: | 10.1016/j.envint.2020.105975 | Rights: | Attribution-NonCommercial-NoDerivatives 4.0 International |
Appears in Collections: | Elements Staff Publications |
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