Please use this identifier to cite or link to this item: https://doi.org/10.1186/s12967-021-02752-2
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dc.titleTranslational stem cell therapy: vascularized skin grafts in skin repair and regeneration
dc.contributor.authorPhua, Qian Hua
dc.contributor.authorHan, Hua Alexander
dc.contributor.authorSoh, Boon-Seng
dc.date.accessioned2022-10-12T07:58:09Z
dc.date.available2022-10-12T07:58:09Z
dc.date.issued2021-02-18
dc.identifier.citationPhua, Qian Hua, Han, Hua Alexander, Soh, Boon-Seng (2021-02-18). Translational stem cell therapy: vascularized skin grafts in skin repair and regeneration. Journal of Translational Medicine 19 (1) : 83. ScholarBank@NUS Repository. https://doi.org/10.1186/s12967-021-02752-2
dc.identifier.issn1479-5876
dc.identifier.urihttps://scholarbank.nus.edu.sg/handle/10635/232347
dc.description.abstractThe skin is made up of a plethora of cells arranged in multiple layers with complex and intricate vascular networks, creating a dynamic microenvironment of cells-to-matrix interactions. With limited donor sites, engineered skin substitute has been in high demand for many therapeutic purposes. Over the years, remarkable progress has occurred in the skin tissue-engineering field to develop skin grafts highly similar to native tissue. However, the major hurdle to successful engraftment is the incorporation of functional vasculature to provide essential nutrients and oxygen supply to the embedded cells. Limitations of traditional tissue engineering have driven the rapid development of vascularized skin tissue production, leading to new technologies such as 3D bioprinting, nano-fabrication and micro-patterning using hydrogel based-scaffold. In particular, the key hope to bioprinting would be the generation of interconnected functional vessels, coupled with the addition of specific cell types to mimic the biological and architectural complexity of the native skin environment. Additionally, stem cells have been gaining interest due to their highly regenerative potential and participation in wound healing. This review briefly summarizes the current cell therapies used in skin regeneration with a focus on the importance of vascularization and recent progress in 3D fabrication approaches to generate vascularized network in the skin tissue graft. © 2021, The Author(s).
dc.publisherBioMed Central Ltd
dc.rightsAttribution 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.sourceScopus OA2021
dc.subject3D bioprinting
dc.subjectEngineered skin graft
dc.subjectSkin regeneration
dc.subjectStem cells
dc.subjectVascularization
dc.typeReview
dc.contributor.departmentDEPT OF MICROBIOLOGY & IMMUNOLOGY
dc.description.doi10.1186/s12967-021-02752-2
dc.description.sourcetitleJournal of Translational Medicine
dc.description.volume19
dc.description.issue1
dc.description.page83
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