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dc.titleAssociation between body mass index and subcortical brain volumes in bipolar disorders–ENIGMA study in 2735 individuals
dc.contributor.authorMcWhinney, Sean R.
dc.contributor.authorAbé, C.
dc.contributor.authorAlda, Martin
dc.contributor.authorBenedetti, Francesco
dc.contributor.authorBøen, E.
dc.contributor.authordel Mar Bonnin, C.
dc.contributor.authorBorgers, Tiana
dc.contributor.authorBrosch, Katharina
dc.contributor.authorCanales-Rodríguez, E.J.
dc.contributor.authorCannon, Dara M.
dc.contributor.authorDannlowski, Udo
dc.contributor.authorDíaz-Zuluaga, A.M.
dc.contributor.authorElvsåshagen, T.
dc.contributor.authorEyler, Lisa T.
dc.contributor.authorFullerton, Janice M.
dc.contributor.authorGoikolea, Jose M.
dc.contributor.authorGoltermann, Janik
dc.contributor.authorGrotegerd, Dominik
dc.contributor.authorHaarman, Bartholomeus C. M.
dc.contributor.authorHahn, Tim
dc.contributor.authorHowells, Fleur M.
dc.contributor.authorIngvar, Martin
dc.contributor.authorKircher, Tilo T. J.
dc.contributor.authorKrug, Axel
dc.contributor.authorKuplicki, Rayus T.
dc.contributor.authorLandén, M.
dc.contributor.authorLemke, Hannah
dc.contributor.authorLiberg, Benny
dc.contributor.authorLopez-Jaramillo, Carlos
dc.contributor.authorMalt, Ulrik F.
dc.contributor.authorMartyn, Fiona M.
dc.contributor.authorMazza, Elena
dc.contributor.authorMcDonald, Colm
dc.contributor.authorMcPhilemy, Genevieve
dc.contributor.authorMeier, Sandra
dc.contributor.authorMeinert, Susanne
dc.contributor.authorMeller, Tina
dc.contributor.authorMelloni, Elisa M. T.
dc.contributor.authorMitchell, Philip B.
dc.contributor.authorNabulsi, Leila.
dc.contributor.authorNenadic, Igor
dc.contributor.authorOpel, Nils
dc.contributor.authorOphoff, Roel A.
dc.contributor.authorOvers, Bronwyn J.
dc.contributor.authorPfarr, Julia-Katharina
dc.contributor.authorPineda-Zapata, Julian A.
dc.contributor.authorPomarol-Clotet, Edith
dc.contributor.authorRaduà, J.
dc.contributor.authorRepple, Jonathan
dc.contributor.authorRichter, Maike
dc.contributor.authorRingwald, Kai G.
dc.contributor.authorRoberts, Gloria
dc.contributor.authorSalvador, Raymond
dc.contributor.authorSavitz, Jonathan
dc.contributor.authorSchmitt, Simon
dc.contributor.authorSchofield, Peter R.
dc.contributor.authorSim, Kang
dc.contributor.authorStein, Dan J.
dc.contributor.authorStein, Frederike
dc.contributor.authorTemmingh, Henk S.
dc.contributor.authorThiel, Katharina
dc.contributor.authorvan Haren, Neeltje E. M.
dc.contributor.authorGestel, Holly Van
dc.contributor.authorVargas, Cristian
dc.contributor.authorVieta, Eduard
dc.contributor.authorVreeker, Annabel
dc.contributor.authorWaltemate, Lena
dc.contributor.authorYatham, Lakshmi N.
dc.contributor.authorChing, Christopher R. K.
dc.contributor.authorAndreassen, Ole
dc.contributor.authorThompson, Paul M.
dc.contributor.authorHajek, Tomas
dc.contributor.authorfor the ENIGMA Bipolar Disorders Working Group.
dc.identifier.citationMcWhinney, Sean R., Abé, C., Alda, Martin, Benedetti, Francesco, Bøen, E., del Mar Bonnin, C., Borgers, Tiana, Brosch, Katharina, Canales-Rodríguez, E.J., Cannon, Dara M., Dannlowski, Udo, Díaz-Zuluaga, A.M., Elvsåshagen, T., Eyler, Lisa T., Fullerton, Janice M., Goikolea, Jose M., Goltermann, Janik, Grotegerd, Dominik, Haarman, Bartholomeus C. M., Hahn, Tim, Howells, Fleur M., Ingvar, Martin, Kircher, Tilo T. J., Krug, Axel, Kuplicki, Rayus T., Landén, M., Lemke, Hannah, Liberg, Benny, Lopez-Jaramillo, Carlos, Malt, Ulrik F., Martyn, Fiona M., Mazza, Elena, McDonald, Colm, McPhilemy, Genevieve, Meier, Sandra, Meinert, Susanne, Meller, Tina, Melloni, Elisa M. T., Mitchell, Philip B., Nabulsi, Leila., Nenadic, Igor, Opel, Nils, Ophoff, Roel A., Overs, Bronwyn J., Pfarr, Julia-Katharina, Pineda-Zapata, Julian A., Pomarol-Clotet, Edith, Raduà, J., Repple, Jonathan, Richter, Maike, Ringwald, Kai G., Roberts, Gloria, Salvador, Raymond, Savitz, Jonathan, Schmitt, Simon, Schofield, Peter R., Sim, Kang, Stein, Dan J., Stein, Frederike, Temmingh, Henk S., Thiel, Katharina, van Haren, Neeltje E. M., Gestel, Holly Van, Vargas, Cristian, Vieta, Eduard, Vreeker, Annabel, Waltemate, Lena, Yatham, Lakshmi N., Ching, Christopher R. K., Andreassen, Ole, Thompson, Paul M., Hajek, Tomas, for the ENIGMA Bipolar Disorders Working Group. (2021-04-16). Association between body mass index and subcortical brain volumes in bipolar disorders–ENIGMA study in 2735 individuals. Molecular Psychiatry 26 (11) : 6806-6819. ScholarBank@NUS Repository.
dc.description.abstractIndividuals with bipolar disorders (BD) frequently suffer from obesity, which is often associated with neurostructural alterations. Yet, the effects of obesity on brain structure in BD are under-researched. We obtained MRI-derived brain subcortical volumes and body mass index (BMI) from 1134 BD and 1601 control individuals from 17 independent research sites within the ENIGMA-BD Working Group. We jointly modeled the effects of BD and BMI on subcortical volumes using mixed-effects modeling and tested for mediation of group differences by obesity using nonparametric bootstrapping. All models controlled for age, sex, hemisphere, total intracranial volume, and data collection site. Relative to controls, individuals with BD had significantly higher BMI, larger lateral ventricular volume, and smaller volumes of amygdala, hippocampus, pallidum, caudate, and thalamus. BMI was positively associated with ventricular and amygdala and negatively with pallidal volumes. When analyzed jointly, both BD and BMI remained associated with volumes of lateral ventricles and amygdala. Adjusting for BMI decreased the BD vs control differences in ventricular volume. Specifically, 18.41% of the association between BD and ventricular volume was mediated by BMI (Z = 2.73, p = 0.006). BMI was associated with similar regional brain volumes as BD, including lateral ventricles, amygdala, and pallidum. Higher BMI may in part account for larger ventricles, one of the most replicated findings in BD. Comorbidity with obesity could explain why neurostructural alterations are more pronounced in some individuals with BD. Future prospective brain imaging studies should investigate whether obesity could be a modifiable risk factor for neuroprogression. © 2021, The Author(s).
dc.publisherSpringer Nature
dc.rightsAttribution 4.0 International
dc.sourceScopus OA2021
dc.contributor.departmentPSYCHOLOGICAL MEDICINE
dc.description.sourcetitleMolecular Psychiatry
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