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https://doi.org/10.3390/cancers13163921
Title: | Vitreoretinal lymphoma | Authors: | Sobolewska, Bianka Chee, Soon-Phaik Zaguia, Fatma Goldstein, Debra Anne Smith, Justine R. Fend, Falko Mochizuki, Manabu Zierhut, Manfred |
Keywords: | CNS lymphoma IL-10/IL-6 ratio Methotrexate MYD88 Vitreoretinal lymphoma |
Issue Date: | 4-Aug-2021 | Publisher: | MDPI AG | Citation: | Sobolewska, Bianka, Chee, Soon-Phaik, Zaguia, Fatma, Goldstein, Debra Anne, Smith, Justine R., Fend, Falko, Mochizuki, Manabu, Zierhut, Manfred (2021-08-04). Vitreoretinal lymphoma. Cancers 13 (16) : 3921. ScholarBank@NUS Repository. https://doi.org/10.3390/cancers13163921 | Rights: | Attribution 4.0 International | Abstract: | Vitreoretinal lymphoma (VRL) is a rare variant of primary central nervous system lymphoma (PCNSL), mostly of diffuse large B cell lymphoma, which affects the retina and/or the vitreous with or without optic nerve involvement. The disease course is aggressive. Up to 90% of the patients develop central nervous system lymphoma within one year. The diagnosis of VRL is challenging due to nonspecific chronic and relapsing uveitis and is made by anterior chamber tab or vitreous aspirate biopsy. There is no established treatment protocol for VRL patients with bilateral involvement without CNS involvement. There are suggestions to use only intravitreal chemotherapy with methotrexate and/or rituximab. Alternatively, systemic high-dose MTX treatment or external beam radiotherapy is used. Further studies are needed to prove and confirm the prophylactic systemic therapy in preventing CNS involvement in limited VRL. © 2021 by the authors. Licensee MDPI, Basel, Switzerland. | Source Title: | Cancers | URI: | https://scholarbank.nus.edu.sg/handle/10635/232043 | ISSN: | 2072-6694 | DOI: | 10.3390/cancers13163921 | Rights: | Attribution 4.0 International |
Appears in Collections: | Staff Publications Elements |
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