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dc.titleEnhancer-derived long non-coding RNAs CCAT1 and CCAT2 at rs6983267 has limited predictability for early stage colorectal carcinoma metastasis
dc.contributor.authorThean, Lai Fun
dc.contributor.authorBlöcker, Christopher
dc.contributor.authorLi, Hui Hua
dc.contributor.authorLo, Michelle
dc.contributor.authorWong, Michelle
dc.contributor.authorTang, Choong Leong
dc.contributor.authorTan, Emile K. W.
dc.contributor.authorRozen, Steven G.
dc.contributor.authorCheah, Peh Yean
dc.identifier.citationThean, Lai Fun, Blöcker, Christopher, Li, Hui Hua, Lo, Michelle, Wong, Michelle, Tang, Choong Leong, Tan, Emile K. W., Rozen, Steven G., Cheah, Peh Yean (2021-01-11). Enhancer-derived long non-coding RNAs CCAT1 and CCAT2 at rs6983267 has limited predictability for early stage colorectal carcinoma metastasis. Scientific Reports 11 (1) : 404. ScholarBank@NUS Repository.
dc.description.abstractUp-regulation of long non-coding RNAs (lncRNAs), colon-cancer associated transcript (CCAT) 1 and 2, was associated with worse prognosis in colorectal cancer (CRC). Nevertheless, their role in predicting metastasis in early-stage CRC is unclear. We measured the expression of CCAT1, CCAT2 and their oncotarget, c-Myc, in 150 matched mucosa-tumour samples of early-stage microsatellite-stable Chinese CRC patients with definitive metastasis status by multiplex real-time RT-PCR assay. Expression of CCAT1, CCAT2 and c-Myc were significantly up-regulated in the tumours compared to matched mucosa (p < 0.0001). The expression of c-Myc in the tumours was significantly correlated to time to metastasis [hazard ratio = 1.47 (1.10–1.97)] and the risk genotype (GG) of rs6983267, located within CCAT2. Expression of c-Myc and CCAT2 in the tumour were also significantly up-regulated in metastasis-positive compared to metastasis-negative patients (p = 0.009 and p = 0.04 respectively). Nevertheless, integrating the expression of CCAT1 and CCAT2 by the Random Forest classifier did not improve the predictive values of ColoMet19, the mRNA-based predictor for metastasis previously developed on the same series of tumours. The role of these two lncRNAs is probably mitigated via their oncotarget, c-Myc, which was not ranked high enough previously to be included in ColoMet19. © 2021, The Author(s).
dc.publisherNature Research
dc.rightsAttribution 4.0 International
dc.sourceScopus OA2021
dc.contributor.departmentDUKE-NUS MEDICAL SCHOOL
dc.contributor.departmentDEAN'S OFFICE (SSH SCH OF PUBLIC HEALTH)
dc.description.sourcetitleScientific Reports
Appears in Collections:Staff Publications

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