Please use this identifier to cite or link to this item:
https://doi.org/10.1038/s41598-020-79906-7
DC Field | Value | |
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dc.title | Enhancer-derived long non-coding RNAs CCAT1 and CCAT2 at rs6983267 has limited predictability for early stage colorectal carcinoma metastasis | |
dc.contributor.author | Thean, Lai Fun | |
dc.contributor.author | Blöcker, Christopher | |
dc.contributor.author | Li, Hui Hua | |
dc.contributor.author | Lo, Michelle | |
dc.contributor.author | Wong, Michelle | |
dc.contributor.author | Tang, Choong Leong | |
dc.contributor.author | Tan, Emile K. W. | |
dc.contributor.author | Rozen, Steven G. | |
dc.contributor.author | Cheah, Peh Yean | |
dc.date.accessioned | 2022-10-11T07:50:34Z | |
dc.date.available | 2022-10-11T07:50:34Z | |
dc.date.issued | 2021-01-11 | |
dc.identifier.citation | Thean, Lai Fun, Blöcker, Christopher, Li, Hui Hua, Lo, Michelle, Wong, Michelle, Tang, Choong Leong, Tan, Emile K. W., Rozen, Steven G., Cheah, Peh Yean (2021-01-11). Enhancer-derived long non-coding RNAs CCAT1 and CCAT2 at rs6983267 has limited predictability for early stage colorectal carcinoma metastasis. Scientific Reports 11 (1) : 404. ScholarBank@NUS Repository. https://doi.org/10.1038/s41598-020-79906-7 | |
dc.identifier.issn | 2045-2322 | |
dc.identifier.uri | https://scholarbank.nus.edu.sg/handle/10635/231977 | |
dc.description.abstract | Up-regulation of long non-coding RNAs (lncRNAs), colon-cancer associated transcript (CCAT) 1 and 2, was associated with worse prognosis in colorectal cancer (CRC). Nevertheless, their role in predicting metastasis in early-stage CRC is unclear. We measured the expression of CCAT1, CCAT2 and their oncotarget, c-Myc, in 150 matched mucosa-tumour samples of early-stage microsatellite-stable Chinese CRC patients with definitive metastasis status by multiplex real-time RT-PCR assay. Expression of CCAT1, CCAT2 and c-Myc were significantly up-regulated in the tumours compared to matched mucosa (p < 0.0001). The expression of c-Myc in the tumours was significantly correlated to time to metastasis [hazard ratio = 1.47 (1.10–1.97)] and the risk genotype (GG) of rs6983267, located within CCAT2. Expression of c-Myc and CCAT2 in the tumour were also significantly up-regulated in metastasis-positive compared to metastasis-negative patients (p = 0.009 and p = 0.04 respectively). Nevertheless, integrating the expression of CCAT1 and CCAT2 by the Random Forest classifier did not improve the predictive values of ColoMet19, the mRNA-based predictor for metastasis previously developed on the same series of tumours. The role of these two lncRNAs is probably mitigated via their oncotarget, c-Myc, which was not ranked high enough previously to be included in ColoMet19. © 2021, The Author(s). | |
dc.publisher | Nature Research | |
dc.rights | Attribution 4.0 International | |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | |
dc.source | Scopus OA2021 | |
dc.type | Article | |
dc.contributor.department | DUKE-NUS MEDICAL SCHOOL | |
dc.contributor.department | DEAN'S OFFICE (SSH SCH OF PUBLIC HEALTH) | |
dc.description.doi | 10.1038/s41598-020-79906-7 | |
dc.description.sourcetitle | Scientific Reports | |
dc.description.volume | 11 | |
dc.description.issue | 1 | |
dc.description.page | 404 | |
Appears in Collections: | Staff Publications Elements |
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