Please use this identifier to cite or link to this item: https://doi.org/10.1371/journal.pone.0218414
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dc.titleDiscordance of epidermal growth factor receptor mutation between primary lung tumor and paired distant metastases in non-small cell lung cancer: A systematic review and meta-analysis
dc.contributor.authorLee, Chia Ching
dc.contributor.authorSoon, Yu Yang
dc.contributor.authorTan, Char Loo
dc.contributor.authorKoh, Wee Yao
dc.contributor.authorLeong, Cheng Nang
dc.contributor.authorTey, Jeremy Chee Seong
dc.contributor.authorTham, Ivan Weng Keong
dc.date.accessioned2022-08-02T04:04:31Z
dc.date.available2022-08-02T04:04:31Z
dc.date.issued2019-06-19
dc.identifier.citationLee, Chia Ching, Soon, Yu Yang, Tan, Char Loo, Koh, Wee Yao, Leong, Cheng Nang, Tey, Jeremy Chee Seong, Tham, Ivan Weng Keong (2019-06-19). Discordance of epidermal growth factor receptor mutation between primary lung tumor and paired distant metastases in non-small cell lung cancer: A systematic review and meta-analysis. PLOS ONE 14 (6). ScholarBank@NUS Repository. https://doi.org/10.1371/journal.pone.0218414
dc.identifier.issn1932-6203,1932-6203
dc.identifier.urihttps://scholarbank.nus.edu.sg/handle/10635/229758
dc.description.abstractPurpose To evaluate the rate of discordance of epidermal growth factor receptor (EGFR) mutation between primary lung tumor and paired distant metastases in non-small-cell lung cancer (NSCLC). Methods We performed a meta-analysis of 17 studies (518 cases) assessing discordance rates of EGFR mutation in primary tumors and paired distant metastases. We performed subgroup analyses based on EGFR mutation status in primary tumor (mutant or wildtype), site of distant metastasis (bone, central nervous system (CNS) or lung/ pleural), methods of testing (direct sequencing or allele-specific testing) and timing of metastasis (synchronous or metachronous). Results The overall discordance rate in EGFR mutation was low at 10.36% (95% CI = 4.23% to 18.79%) and varied widely between studies (I2 = 83.18%). The EGFR discordance rate was statistically significantly higher in bone metastases (45.49%, 95% CI = 14.13 to 79.02) than CNS (17.26%, 95% CI = 7.64 to 29.74; P = 0.002) and lung/ pleural metastases (8.17%, 95% CI = 3.35 to 14.85; P < 0.001). Subgroup analyses did not demonstrate any significant effect modification on the discordance rates by the EGFR mutation status in primary lung tumor, methods of testing and timing of metastasis. Conclusion The overall discordance rate in EGFR mutation between primary lung tumor and paired distant metastases in NSCLC is low, although higher discordance rates were observed in bone metastases compared with CNS and lung/pleural metastases. Future studies assessing the impact of EGFR mutation discordance on treatment outcomes are required.
dc.language.isoen
dc.publisherPUBLIC LIBRARY SCIENCE
dc.sourceElements
dc.subjectScience & Technology
dc.subjectMultidisciplinary Sciences
dc.subjectScience & Technology - Other Topics
dc.subjectTYROSINE KINASE INHIBITORS
dc.subjectPARALLEL EVOLUTION
dc.subjectBRAIN METASTASES
dc.subjectBONE METASTASES
dc.subjectEGFR MUTATIONS
dc.subjectGENE
dc.subjectCARCINOMA
dc.subjectHETEROGENEITY
dc.subjectMECHANISMS
dc.subjectEXPRESSION
dc.typeReview
dc.date.updated2022-07-24T07:00:05Z
dc.contributor.departmentMEDICINE
dc.contributor.departmentPATHOLOGY
dc.description.doi10.1371/journal.pone.0218414
dc.description.sourcetitlePLOS ONE
dc.description.volume14
dc.description.issue6
dc.published.statePublished
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