Please use this identifier to cite or link to this item: https://doi.org/10.3904/kjim.2021.180
Title: Eosinophilic endotype of chronic obstructive pulmonary disease: similarities and differences from asthma
Authors: Li, Andrew
Chan, Hiang Ping 
Gan, Phyllis XL
Liew, Mei Fong
Wong, WS Fred 
Lim, Hui-Fang 
Keywords: Science & Technology
Life Sciences & Biomedicine
Medicine, General & Internal
General & Internal Medicine
Pulmonary disease
chronic obstructive
Inhaled corticosteroids
Eosinophilia
POST-HOC ANALYSIS
INHALED CORTICOSTEROIDS
DOUBLE-BLIND
SPUTUM EOSINOPHILIA
BLOOD EOSINOPHILS
OVERLAP SYNDROME
PARALLEL-GROUP
CLINICAL PHENOTYPES
AIRWAY INFLAMMATION
EXACERBATION RISK
Issue Date: 1-Nov-2021
Publisher: KOREAN ASSOC INTERNAL MEDICINE
Citation: Li, Andrew, Chan, Hiang Ping, Gan, Phyllis XL, Liew, Mei Fong, Wong, WS Fred, Lim, Hui-Fang (2021-11-01). Eosinophilic endotype of chronic obstructive pulmonary disease: similarities and differences from asthma. KOREAN JOURNAL OF INTERNAL MEDICINE 36 (6) : 1305-1319. ScholarBank@NUS Repository. https://doi.org/10.3904/kjim.2021.180
Abstract: Approximately 25% to 40% of patients with chronic obstructive pulmonary disease (COPD) have the eosinophilic endotype. It is important to identify this group accurately because they are more symptomatic and are at increased risk for exacerbations and accelerated decline in forced expiratory volume in the 1st second. Importantly, this endotype is a marker of treat ment responsiveness to inhaled corticosteroid (ICS), resulting in decreased mortality risk. In this review, we highlight differences in the biology of eosinophils in COPD compared to asthma and the different definitions of the COPD eosinophilic endotype based on sputum and blood eosinophil count (BEC) with the corresponding limitations. Although BEC is useful as a biomarker for eosinophilic COPD endotype, optimal BEC cutoffs can be combined with clinical characteristics to improve its sensitivity and specificity. A targeted approach comprising airway eosinophilia and appropriate clinical and physiological features may improve identification of subgroups of patients who would benefit from biologic therapy or early use of ICS for disease modification.
Source Title: KOREAN JOURNAL OF INTERNAL MEDICINE
URI: https://scholarbank.nus.edu.sg/handle/10635/228958
ISSN: 1226-3303,2005-6648
DOI: 10.3904/kjim.2021.180
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