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dc.titleIntegrated structural and functional atlases of Asian children from infancy to childhood
dc.contributor.authorZhu J.
dc.contributor.authorZhang, H.
dc.contributor.authorChong, Y.S.
dc.contributor.authorShek, L.P.
dc.contributor.authorGluckman P.D.
dc.contributor.authorMeaney M.J.
dc.contributor.authorFortier M.V.
dc.contributor.authorQiu, A.
dc.identifier.citationZhu J., Zhang, H., Chong, Y.S., Shek, L.P., Gluckman P.D., Meaney M.J., Fortier M.V., Qiu, A. (2021). Integrated structural and functional atlases of Asian children from infancy to childhood. NeuroImage 245 : 118716. ScholarBank@NUS Repository.
dc.description.abstractThe developing brain grows exponentially in the first few years of life. There is a need to have age-appropriate brain atlases that coherently characterize the geometry of the cerebral cortex, white matter tracts, and functional organization. This study employed multi-modal brain images of an Asian cohort and constructed brain structural and functional atlases for 6-month-old infants, 4.5-, 6-, and 7.5-year-old children. We exploited large deformation diffeomorphic metric mapping and probabilistic atlas generation approaches to integrate structural MRI and diffusion weighted images (DWIs) and to create the atlas where white matter tracts well fit into the cortical folding pattern. Based on this structural atlas, we then employed spectral clustering to parcellate the brain into functional networks from resting-state fMRI (rs-fMRI). Our results provided the atlas that characterizes the cortical folding geometry, subcortical regions, deep white matter tracts, as well as functional networks in a stereotaxic coordinate space for the four different age groups. The functional networks consisting of the primary cortex were well established in infancy and remained stable to childhood, while specific higher-order functional networks showed specific patterns of hemispherical, subcortical-cerebellar, and cortical-cortical integration and segregation from infancy to childhood. Our multi-modal fusion analysis demonstrated the use of the integrated structural and functional atlas for understanding coherent patterns of brain anatomical and functional development during childhood. Hence, our atlases can be potentially used to study coherent patterns of brain anatomical and functional development. © 2021
dc.publisherAcademic Press Inc.
dc.subjectBrain growth
dc.subjectDiffusion weighted imaging
dc.subjectFunctional networks
dc.subjectResting-state fMRI
dc.subjectStructural magnetic resonance imaging
dc.subjectWhite matter tracts
dc.contributor.departmentDEPT OF BIOMEDICAL ENGINEERING
dc.contributor.departmentDEAN'S OFFICE (MEDICINE)
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