Please use this identifier to cite or link to this item:
https://doi.org/10.1016/j.ijid.2021.09.048
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dc.title | Lack of latent tuberculosis (TB) screening and delay in anti-retroviral therapy initiation in HIV-TB co-infection: an 11-year study in an intermediate TB-burden country | |
dc.contributor.author | Teng, Vannesa Yue May | |
dc.contributor.author | Chua, Yan Ting | |
dc.contributor.author | Lai, Eunice En Ni | |
dc.contributor.author | Mukherjee, Shilpa | |
dc.contributor.author | Michaels, Jessica | |
dc.contributor.author | Wong, Chen Seong | |
dc.contributor.author | Shen, Liang | |
dc.contributor.author | Leo, Yee Sin | |
dc.contributor.author | Young, Barnaby | |
dc.contributor.author | Archuleta, Sophia | |
dc.contributor.author | Ong, Catherine WM | |
dc.date.accessioned | 2022-07-06T08:27:40Z | |
dc.date.available | 2022-07-06T08:27:40Z | |
dc.date.issued | 2021-11-05 | |
dc.identifier.citation | Teng, Vannesa Yue May, Chua, Yan Ting, Lai, Eunice En Ni, Mukherjee, Shilpa, Michaels, Jessica, Wong, Chen Seong, Shen, Liang, Leo, Yee Sin, Young, Barnaby, Archuleta, Sophia, Ong, Catherine WM (2021-11-05). Lack of latent tuberculosis (TB) screening and delay in anti-retroviral therapy initiation in HIV-TB co-infection: an 11-year study in an intermediate TB-burden country. INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES 113 : 178-183. ScholarBank@NUS Repository. https://doi.org/10.1016/j.ijid.2021.09.048 | |
dc.identifier.issn | 12019712 | |
dc.identifier.issn | 18783511 | |
dc.identifier.uri | https://scholarbank.nus.edu.sg/handle/10635/228040 | |
dc.description.abstract | Objectives: To examine the prevalence and characteristics of HIV-tuberculosis (TB) co-infected patients in Singapore, an intermediate TB-burden country. Methods: Retrospective data across 11 years was obtained from the National University Hospital (NUH), a quaternary hospital and the National Centre for Infectious Diseases (NCID), the national HIV center. Results: From December 2005 to December 2016, 4015 HIV-infected patients were managed at NUH and NCID, of whom, respectively, 48 and 272 were diagnosed with active TB disease. Only 2 patients (0.6%) were screened for latent TB infection on HIV diagnosis. Mean CD4 count at TB diagnosis was 125.0 ± 153.9 cells/mm3. More patients with HIV diagnosed ≥6 weeks before TB (41%) were associated with CD4 counts >200 cells/mm3 than patients with TB diagnosed ≥6 weeks before HIV (2%). Of 124 (38.6%) HIV-TB patients with CD4 count ≤50 cells/mm3, only 18 (14.2%) started anti-retroviral therapy (ART) in <2 weeks. Of patients with pulmonary TB, 33.5% had normal chest x-ray. Conclusions: Latent TB infection screening in HIV-infected patients is low, and ART initiation is delayed in HIV-TB patients with CD4 ≤50 cells/mm3. Pulmonary TB patients with HIV can be infectious despite normal chest x-ray. Clinical practices can be further improved to benefit HIV-TB patients. | |
dc.language.iso | en | |
dc.publisher | ELSEVIER SCI LTD | |
dc.source | Elements | |
dc.subject | Science & Technology | |
dc.subject | Life Sciences & Biomedicine | |
dc.subject | Infectious Diseases | |
dc.subject | Tuberculosis | |
dc.subject | HIV | |
dc.subject | latent tuberculosis infection | |
dc.subject | INFECTION | |
dc.type | Article | |
dc.date.updated | 2022-07-06T04:33:53Z | |
dc.contributor.department | DEAN'S OFFICE (MEDICINE) | |
dc.contributor.department | MEDICINE | |
dc.contributor.department | SAW SWEE HOCK SCHOOL OF PUBLIC HEALTH | |
dc.description.doi | 10.1016/j.ijid.2021.09.048 | |
dc.description.sourcetitle | INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES | |
dc.description.volume | 113 | |
dc.description.page | 178-183 | |
dc.published.state | Published | |
Appears in Collections: | Staff Publications Elements |
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