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https://doi.org/10.1016/j.nantod.2020.100993
Title: | Combination of tumor fragments and nanotechnology as a therapeutic approach: Treating a tumor with tumor | Authors: | Chen, X Zhang, Y |
Keywords: | Tumor-derived fragments cell membrane exosomes cancer therapy immunotherapy |
Issue Date: | 1-Dec-2020 | Publisher: | Elsevier BV | Citation: | Chen, X, Zhang, Y (2020-12-01). Combination of tumor fragments and nanotechnology as a therapeutic approach: Treating a tumor with tumor. Nano Today 35 : 100993-100993. ScholarBank@NUS Repository. https://doi.org/10.1016/j.nantod.2020.100993 | Abstract: | Cancer with high mortality is a serious threat to human health. Thus, favorable approaches for efficient elimination of tumors are urgently needed. Recently, a new antitumor strategy of tumor-derived fragments (TDFs) interfered with nanotechnology has been developed for highly specific and efficient tumor therapy. On one hand, TDF-based nanoformulations (termed as TDF-NFs) and nanoparticle-induced immunogenic dying tumor cells (IDTCs) can act as ex situ/in situ vaccines to elicit the immune responses for cancer immunotherapy. On the other hand, TDF-NFs can be drug carriers for cancer theranostics. In this review, the immune regulation mechanisms of various TDFs including tumor-derived DNA/RNA, tumor cell membranes, tumor-derived exosomes, whole tumor lysates, and IDTCs are summarized, and the applications of nanotechnology-intervened TDFs as vaccines and vehicles in tumor therapy are also highlighted. It is hoped that the review will inspire researchers to further construct functional TDF-based nanovaccines and nanocarriers, facilitating the development of novel antitumor strategies. | Source Title: | Nano Today | URI: | https://scholarbank.nus.edu.sg/handle/10635/227577 | ISSN: | 1748-0132 1878-044X |
DOI: | 10.1016/j.nantod.2020.100993 |
Appears in Collections: | Staff Publications Elements |
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