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Title: Combination of tumor fragments and nanotechnology as a therapeutic approach: Treating a tumor with tumor
Authors: Chen, X 
Zhang, Y 
Keywords: Tumor-derived fragments
cell membrane
cancer therapy
Issue Date: 1-Dec-2020
Publisher: Elsevier BV
Citation: Chen, X, Zhang, Y (2020-12-01). Combination of tumor fragments and nanotechnology as a therapeutic approach: Treating a tumor with tumor. Nano Today 35 : 100993-100993. ScholarBank@NUS Repository.
Abstract: Cancer with high mortality is a serious threat to human health. Thus, favorable approaches for efficient elimination of tumors are urgently needed. Recently, a new antitumor strategy of tumor-derived fragments (TDFs) interfered with nanotechnology has been developed for highly specific and efficient tumor therapy. On one hand, TDF-based nanoformulations (termed as TDF-NFs) and nanoparticle-induced immunogenic dying tumor cells (IDTCs) can act as ex situ/in situ vaccines to elicit the immune responses for cancer immunotherapy. On the other hand, TDF-NFs can be drug carriers for cancer theranostics. In this review, the immune regulation mechanisms of various TDFs including tumor-derived DNA/RNA, tumor cell membranes, tumor-derived exosomes, whole tumor lysates, and IDTCs are summarized, and the applications of nanotechnology-intervened TDFs as vaccines and vehicles in tumor therapy are also highlighted. It is hoped that the review will inspire researchers to further construct functional TDF-based nanovaccines and nanocarriers, facilitating the development of novel antitumor strategies.
Source Title: Nano Today
ISSN: 1748-0132
DOI: 10.1016/j.nantod.2020.100993
Appears in Collections:Staff Publications

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