Please use this identifier to cite or link to this item:
https://doi.org/10.1038/s42003-021-01897-6
DC Field | Value | |
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dc.title | Identification of a targetable KRAS-mutant epithelial population in non-small cell lung cancer | |
dc.contributor.author | Maroni, Giorgia | |
dc.contributor.author | Bassal, Mahmoud A | |
dc.contributor.author | Krishnan, Indira | |
dc.contributor.author | Fhu, Chee Wai | |
dc.contributor.author | Savova, Virginia | |
dc.contributor.author | Zilionis, Rapolas | |
dc.contributor.author | Maymi, Valerie A | |
dc.contributor.author | Pandell, Nicole | |
dc.contributor.author | Csizmadia, Eva | |
dc.contributor.author | Zhang, Junyan | |
dc.contributor.author | Storti, Barbara | |
dc.contributor.author | Castano, Julio | |
dc.contributor.author | Panella, Riccardo | |
dc.contributor.author | Li, Jia | |
dc.contributor.author | Gustafson, Corinne E | |
dc.contributor.author | Fox, Sam | |
dc.contributor.author | Levy, Rachel D | |
dc.contributor.author | Meyerovitz, Claire | |
dc.contributor.author | Tramontozzi, Peter J | |
dc.contributor.author | Vermilya, Kimberly | |
dc.contributor.author | De Rienzo, Assunta | |
dc.contributor.author | Crucitta, Stefania | |
dc.contributor.author | Basseres, Daniela S | |
dc.contributor.author | Weetall, Marla | |
dc.contributor.author | Branstrom, Art | |
dc.contributor.author | Giorgetti, Alessandra | |
dc.contributor.author | Ciampi, Raffaele | |
dc.contributor.author | Del Re, Marzia | |
dc.contributor.author | Danesi, Romano | |
dc.contributor.author | Bizzarri, Ranieri | |
dc.contributor.author | Yang, Henry | |
dc.contributor.author | Kocher, Olivier | |
dc.contributor.author | Klein, Allon M | |
dc.contributor.author | Welner, Robert S | |
dc.contributor.author | Bueno, Raphael | |
dc.contributor.author | Magli, Maria Cristina | |
dc.contributor.author | Clohessy, John G | |
dc.contributor.author | Ali, Azhar | |
dc.contributor.author | Tenen, Daniel G | |
dc.contributor.author | Levantini, Elena | |
dc.date.accessioned | 2022-06-07T09:11:16Z | |
dc.date.available | 2022-06-07T09:11:16Z | |
dc.date.issued | 2021-04-14 | |
dc.identifier.citation | Maroni, Giorgia, Bassal, Mahmoud A, Krishnan, Indira, Fhu, Chee Wai, Savova, Virginia, Zilionis, Rapolas, Maymi, Valerie A, Pandell, Nicole, Csizmadia, Eva, Zhang, Junyan, Storti, Barbara, Castano, Julio, Panella, Riccardo, Li, Jia, Gustafson, Corinne E, Fox, Sam, Levy, Rachel D, Meyerovitz, Claire, Tramontozzi, Peter J, Vermilya, Kimberly, De Rienzo, Assunta, Crucitta, Stefania, Basseres, Daniela S, Weetall, Marla, Branstrom, Art, Giorgetti, Alessandra, Ciampi, Raffaele, Del Re, Marzia, Danesi, Romano, Bizzarri, Ranieri, Yang, Henry, Kocher, Olivier, Klein, Allon M, Welner, Robert S, Bueno, Raphael, Magli, Maria Cristina, Clohessy, John G, Ali, Azhar, Tenen, Daniel G, Levantini, Elena (2021-04-14). Identification of a targetable KRAS-mutant epithelial population in non-small cell lung cancer. COMMUNICATIONS BIOLOGY 4 (1). ScholarBank@NUS Repository. https://doi.org/10.1038/s42003-021-01897-6 | |
dc.identifier.issn | 2399-3642 | |
dc.identifier.uri | https://scholarbank.nus.edu.sg/handle/10635/226657 | |
dc.description.abstract | Lung cancer is the leading cause of cancer deaths. Tumor heterogeneity, which hampers development of targeted therapies, was herein deconvoluted via single cell RNA sequencing in aggressive human adenocarcinomas (carrying Kras-mutations) and comparable murine model. We identified a tumor-specific, mutant-KRAS-associated subpopulation which is conserved in both human and murine lung cancer. We previously reported a key role for the oncogene BMI-1 in adenocarcinomas. We therefore investigated the effects of in vivo PTC596 treatment, which affects BMI-1 activity, in our murine model. Post-treatment, MRI analysis showed decreased tumor size, while single cell transcriptomics concomitantly detected near complete ablation of the mutant-KRAS-associated subpopulation, signifying the presence of a pharmacologically targetable, tumor-associated subpopulation. Our findings therefore hold promise for the development of a targeted therapy for KRAS-mutant adenocarcinomas. | |
dc.language.iso | en | |
dc.publisher | NATURE PORTFOLIO | |
dc.source | Elements | |
dc.subject | Science & Technology | |
dc.subject | Life Sciences & Biomedicine | |
dc.subject | Biology | |
dc.subject | Multidisciplinary Sciences | |
dc.subject | Life Sciences & Biomedicine - Other Topics | |
dc.subject | Science & Technology - Other Topics | |
dc.subject | DIFFERENTIAL EXPRESSION ANALYSIS | |
dc.subject | BMI-1 ONCOPROTEIN | |
dc.subject | GENE-EXPRESSION | |
dc.subject | MICROARRAY ANALYSIS | |
dc.subject | OVEREXPRESSION | |
dc.subject | PROGRESSION | |
dc.subject | CARCINOMA | |
dc.subject | ATLAS | |
dc.type | Article | |
dc.date.updated | 2022-06-07T01:34:11Z | |
dc.contributor.department | CANCER SCIENCE INSTITUTE OF SINGAPORE | |
dc.contributor.department | MEDICINE | |
dc.description.doi | 10.1038/s42003-021-01897-6 | |
dc.description.sourcetitle | COMMUNICATIONS BIOLOGY | |
dc.description.volume | 4 | |
dc.description.issue | 1 | |
dc.published.state | Published | |
Appears in Collections: | Staff Publications Elements |
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2021Comms Biol_EL_GM.pdf | 25.56 MB | Adobe PDF | OPEN | None | View/Download |
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