Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.ijcard.2021.01.066
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dc.titleStandard and emerging CMR methods for mitral regurgitation quantification
dc.contributor.authorFidock, Benjamin
dc.contributor.authorArcher, Gareth
dc.contributor.authorBarker, Natasha
dc.contributor.authorElhawaz, Alaa
dc.contributor.authorAl-Mohammad, Abdallah
dc.contributor.authorRothman, Alexander
dc.contributor.authorHose, Rod
dc.contributor.authorHall, Ian R
dc.contributor.authorGrech, Ever
dc.contributor.authorBriffa, Norman
dc.contributor.authorLewis, Nigel
dc.contributor.authorvan der Geest, Rob J
dc.contributor.authorZhang, Jun-Mei
dc.contributor.authorZhong, Liang
dc.contributor.authorSwift, Andrew J
dc.contributor.authorWild, James M
dc.contributor.authorDe Garate, Estefania
dc.contributor.authorBucciarelli-Ducci, Chiara
dc.contributor.authorBax, Jeroen J
dc.contributor.authorPlein, Sven
dc.contributor.authorMyerson, Saul
dc.contributor.authorGarg, Pankaj
dc.date.accessioned2022-06-07T08:19:52Z
dc.date.available2022-06-07T08:19:52Z
dc.date.issued2021-03-29
dc.identifier.citationFidock, Benjamin, Archer, Gareth, Barker, Natasha, Elhawaz, Alaa, Al-Mohammad, Abdallah, Rothman, Alexander, Hose, Rod, Hall, Ian R, Grech, Ever, Briffa, Norman, Lewis, Nigel, van der Geest, Rob J, Zhang, Jun-Mei, Zhong, Liang, Swift, Andrew J, Wild, James M, De Garate, Estefania, Bucciarelli-Ducci, Chiara, Bax, Jeroen J, Plein, Sven, Myerson, Saul, Garg, Pankaj (2021-03-29). Standard and emerging CMR methods for mitral regurgitation quantification. INTERNATIONAL JOURNAL OF CARDIOLOGY 331 : 316-321. ScholarBank@NUS Repository. https://doi.org/10.1016/j.ijcard.2021.01.066
dc.identifier.issn01675273
dc.identifier.issn18741754
dc.identifier.urihttps://scholarbank.nus.edu.sg/handle/10635/226644
dc.description.abstractBackground: There are several methods to quantify mitral regurgitation (MR) by cardiovascular magnetic resonance (CMR). The interoperability of these methods and their reproducibility remains undetermined. Objective: To determine the agreement and reproducibility of different MR quantification methods by CMR across all aetiologies. Methods: Thirty-five patients with MR were recruited (primary MR = 12, secondary MR = 10 and MVR = 13). Patients underwent CMR, including cines and four-dimensional flow (4D flow). Four methods were evaluated: MRStandard (left ventricular stroke volume - aortic forward flow by phase contrast), MRLVRV (left ventricular stroke volume - right ventricular stroke volume), MRJet (direct jet quantification by 4D flow) and MRMVAV (mitral forward flow by 4D flow - aortic forward flow by 4D flow). For all cases and MR types, 520 MR volumes were recorded by these 4 methods for intra−/inter-observer tests. Results: In primary MR, MRMVAV and MRLVRV were comparable to MRStandard (P > 0.05). MRJet resulted in significantly higher MR volumes when compared to MRStandard (P < 0.05) In secondary MR and MVR cases, all methods were comparable. In intra-observer tests, MRMVAV demonstrated least bias with best limits of agreement (bias = −0.1 ml, −8 ml to 7.8 ml, P = 0.9) and best concordance correlation coefficient (CCC = 0.96, P < 0.01). In inter-observer tests, for primary MR and MVR, least bias and highest CCC were observed for MRMVAV. For secondary MR, bias was lowest for MRJet (−0.1 ml, P[dbnd]NS). Conclusion: CMR methods of MR quantification demonstrate agreement in secondary MR and MVR. In primary MR, this was not observed. Across all types of MR, MRMVAV quantification demonstrated the highest reproducibility and consistency.
dc.language.isoen
dc.publisherELSEVIER IRELAND LTD
dc.sourceElements
dc.subjectScience & Technology
dc.subjectLife Sciences & Biomedicine
dc.subjectCardiac & Cardiovascular Systems
dc.subjectCardiovascular System & Cardiology
dc.subjectMitral valve insufficiency
dc.subjectReproducibility of results
dc.subjectMagnetic resonance imaging
dc.subjectCARDIOVASCULAR MAGNETIC-RESONANCE
dc.subject4-DIMENSIONAL FLOW
dc.subjectBLOOD-FLOW
dc.subjectVALVE
dc.typeArticle
dc.date.updated2022-06-07T06:10:11Z
dc.contributor.departmentDEAN'S OFFICE (DUKE-NUS MEDICAL SCHOOL)
dc.description.doi10.1016/j.ijcard.2021.01.066
dc.description.sourcetitleINTERNATIONAL JOURNAL OF CARDIOLOGY
dc.description.volume331
dc.description.page316-321
dc.published.statePublished
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