Please use this identifier to cite or link to this item:
https://doi.org/10.3402/pba.v4.24824
DC Field | Value | |
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dc.title | An immunohistochemical approach for monitoring effects of exercise on tumor stromal cells in old mice. | |
dc.contributor.author | Pettan-Brewer, Christina | |
dc.contributor.author | Goh, Jorming | |
dc.contributor.author | Ladiges, Warren C | |
dc.date.accessioned | 2022-04-21T09:15:38Z | |
dc.date.available | 2022-04-21T09:15:38Z | |
dc.date.issued | 2014 | |
dc.identifier.citation | Pettan-Brewer, Christina, Goh, Jorming, Ladiges, Warren C (2014). An immunohistochemical approach for monitoring effects of exercise on tumor stromal cells in old mice.. Pathobiology of Aging & Age-related Diseases 4 (1) : 24824-24824. ScholarBank@NUS Repository. https://doi.org/10.3402/pba.v4.24824 | |
dc.identifier.issn | 2001-0001 | |
dc.identifier.uri | https://scholarbank.nus.edu.sg/handle/10635/219455 | |
dc.description.abstract | Epidemiological evidence supports a protective effect of physical activity for breast cancer in older women, but the mechanisms are not well understood. We used 18-month-old BALB/c mice injected in the mammary fat pad with syngeneic 4T1 tumor cells as a model of invasive breast cancer. During the tumor progression phase, there was a significant decrease in labeling for F4/80, a marker for mouse macrophages, and CD34, a marker for vascular endothelial cells, in primary tumors from mice that ran higher average distances compared to mice that ran lower average distances (p≤0.05). These observations suggest that immunohistochemistry can be used to monitor stromal cell populations in tumors from old mice under exercise conditions. | |
dc.publisher | Informa UK Limited | |
dc.source | Elements | |
dc.subject | aging | |
dc.subject | breast cancer | |
dc.subject | exercise | |
dc.subject | immunohistochemistry | |
dc.subject | tumor microenvironment | |
dc.subject | tumor stromal cells | |
dc.type | Article | |
dc.date.updated | 2022-04-21T02:11:09Z | |
dc.contributor.department | PHYSIOLOGY | |
dc.description.doi | 10.3402/pba.v4.24824 | |
dc.description.sourcetitle | Pathobiology of Aging & Age-related Diseases | |
dc.description.volume | 4 | |
dc.description.issue | 1 | |
dc.description.page | 24824-24824 | |
dc.published.state | Unpublished | |
Appears in Collections: | Staff Publications Elements |
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