Please use this identifier to cite or link to this item:
https://doi.org/10.1016/j.redox.2021.102032
DC Field | Value | |
---|---|---|
dc.title | The redox-senescence axis and its therapeutic targeting | |
dc.contributor.author | Ngoi, Natalie YL | |
dc.contributor.author | Liew, Angeline QX | |
dc.contributor.author | Chong, Stephen JF | |
dc.contributor.author | Davids, Matthew S | |
dc.contributor.author | Clement, Marie-Veronique | |
dc.contributor.author | Pervaiz, Shazib | |
dc.date.accessioned | 2022-04-08T08:04:19Z | |
dc.date.available | 2022-04-08T08:04:19Z | |
dc.date.issued | 2021-06-17 | |
dc.identifier.citation | Ngoi, Natalie YL, Liew, Angeline QX, Chong, Stephen JF, Davids, Matthew S, Clement, Marie-Veronique, Pervaiz, Shazib (2021-06-17). The redox-senescence axis and its therapeutic targeting. REDOX BIOLOGY 45. ScholarBank@NUS Repository. https://doi.org/10.1016/j.redox.2021.102032 | |
dc.identifier.issn | 22132317 | |
dc.identifier.uri | https://scholarbank.nus.edu.sg/handle/10635/218758 | |
dc.description.abstract | Significance: Cellular growth arrest, associated with ‘senescence’, helps to safeguard against the accumulation of DNA damage which is often recognized as the underlying mechanism of a wide variety of age-related pathologies including cancer. Cellular senescence has also been described as a ‘double-edged sword’. In cancer, for example, the creation of an immune-suppressive milieu by senescent tumor cells through the senescence-associated secretory phenotype contributes toward carcinogenesis and cancer progression. Recent advances: The potential for cellular senescence to confer multi-faceted effects on tissue fate has led to a rejuvenated interest in its landscape and targeting. Interestingly, redox pathways have been described as both triggers and propagators of cellular senescence, leading to intricate cross-links between both pathways. Critical issues: In this review, we describe the mechanisms driving cellular senescence, the interface with cellular redox metabolism as well as the role that chemotherapy-induced senescence plays in secondary carcinogenesis. Notably, the role that anti-apoptotic proteins of the Bcl-2 family play in inducing drug resistance via mechanisms that involve senescence induction. Future directions: Though the therapeutic targeting of senescent cells as cancer therapy remains in its infancy, we summarize the current development of senotherapeutics, including recognized senotherapies, as well as the repurposing of drugs as senomorphic/senolytic candidates. | |
dc.language.iso | en | |
dc.publisher | ELSEVIER | |
dc.source | Elements | |
dc.subject | Science & Technology | |
dc.subject | Life Sciences & Biomedicine | |
dc.subject | Biochemistry & Molecular Biology | |
dc.subject | Senescence | |
dc.subject | SASP | |
dc.subject | ROS | |
dc.subject | Cancer therapy | |
dc.subject | Senolytics | |
dc.subject | TERMINAL PROLIFERATION ARREST | |
dc.subject | INDUCED PREMATURE SENESCENCE | |
dc.subject | DIETARY FLAVONOID FISETIN | |
dc.subject | DRUG-INDUCED APOPTOSIS | |
dc.subject | CELLULAR SENESCENCE | |
dc.subject | DNA-DAMAGE | |
dc.subject | CANCER-CELLS | |
dc.subject | TUMOR-CELLS | |
dc.subject | SECRETORY PHENOTYPE | |
dc.subject | HUMAN FIBROBLASTS | |
dc.type | Article | |
dc.date.updated | 2022-04-07T04:37:24Z | |
dc.contributor.department | BIOCHEMISTRY | |
dc.contributor.department | MEDICINE | |
dc.contributor.department | PHYSIOLOGY | |
dc.description.doi | 10.1016/j.redox.2021.102032 | |
dc.description.sourcetitle | REDOX BIOLOGY | |
dc.description.volume | 45 | |
dc.published.state | Published | |
Appears in Collections: | Elements Staff Publications |
Show simple item record
Files in This Item:
File | Description | Size | Format | Access Settings | Version | |
---|---|---|---|---|---|---|
The redox-senescence axis and its therapeutic targeting.pdf | 4.11 MB | Adobe PDF | OPEN | Published | View/Download |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.