Please use this identifier to cite or link to this item:
https://doi.org/10.1007/s00345-018-2566-2
DC Field | Value | |
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dc.title | Visceral obesity in Asian living kidney donors significantly impacts early renal function after donor nephrectomy | |
dc.contributor.author | Pek, Gregory Xiang Wen | |
dc.contributor.author | Ngoh, Clara Lee Ying | |
dc.contributor.author | Teo, Boon Wee | |
dc.contributor.author | Vathsala, Anantharaman | |
dc.contributor.author | Goh, Benjamin Yen Seow | |
dc.contributor.author | Yong, Clement Hsiang Rong | |
dc.contributor.author | Raman, Lata | |
dc.contributor.author | Tiong, Ho Yee | |
dc.date.accessioned | 2022-03-14T01:54:50Z | |
dc.date.available | 2022-03-14T01:54:50Z | |
dc.date.issued | 2019-10-01 | |
dc.identifier.citation | Pek, Gregory Xiang Wen, Ngoh, Clara Lee Ying, Teo, Boon Wee, Vathsala, Anantharaman, Goh, Benjamin Yen Seow, Yong, Clement Hsiang Rong, Raman, Lata, Tiong, Ho Yee (2019-10-01). Visceral obesity in Asian living kidney donors significantly impacts early renal function after donor nephrectomy. WORLD JOURNAL OF UROLOGY 37 (10) : 2231-2236. ScholarBank@NUS Repository. https://doi.org/10.1007/s00345-018-2566-2 | |
dc.identifier.issn | 0724-4983 | |
dc.identifier.issn | 1433-8726 | |
dc.identifier.uri | https://scholarbank.nus.edu.sg/handle/10635/217018 | |
dc.description.abstract | Introduction: Obesity may be a risk factor for kidney donors to develop reduced renal function. The Framingham heart study suggested that visceral adipose tissue (VAT) confers a more adverse metabolic profile compared with subcutaneous adipose tissue (SAT). Asians tend to have a higher VAT composition and it is unclear if their kidney function is affected differently. We hypothesized that Asian living kidney donors who have visceral obesity are at a higher risk of renal function deterioration 1 year after donation. Methods: Between 2011 and 2014, we retrospectively evaluated data from 73 consecutive patients (52% male; mean age 44.9 ± 11.7 years) before they underwent donor nephrectomy and at their 1 year routine follow-up. VAT and SAT were measured at the level of the umbilicus on pre-operative computerized tomography (CT). Visceral obesity (VO) was defined as a VAT > 100 cm [2] and patients were then further divided and compared in two subgroups: VAT > 100 and < 100 cm [2]. Estimated glomerular filtration rate (eGFR, mL/min per 1.73 m [2]) was calculated using the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equation pre-operatively and 1 year post-operatively. Results: Both subgroups had similar baseline kidney function (P = NS) pre-operatively. At the 1 year follow-up, patients with VO experienced a more significant decline of renal function (109 ± 9 to 89 ± 8 mL/min per 1.73 m2), compared to those without VO (111 ± 12 to 96 ± 11 mL/min per 1.73 m2, P = 0.013). VO was associated with a body mass index (BMI) > 25 kg/m2 (P < 0.001), male gender (P < 0.001) and older age at the time of donor nephrectomy (48.0 vs 39.5 years, P = 0.01). The presence of hypertension or hyperlipidaemia pre-operatively, choice of surgical approach, and post-operative complication rates, did not differ significantly between the subgroups. Conclusions: Visceral obesity as defined by VAT > 100 cm2 at the level of the umbilicus on cross-sectional imaging, may have a significant impact on early renal function after donor nephrectomy. Adiposity markers, as measured by cross-sectional CT imaging, may be incorporated into routine pre-operative kidney donor workup. | |
dc.language.iso | en | |
dc.publisher | SPRINGER | |
dc.source | Elements | |
dc.subject | Science & Technology | |
dc.subject | Life Sciences & Biomedicine | |
dc.subject | Urology & Nephrology | |
dc.subject | Visceral obesity | |
dc.subject | Obesity | |
dc.subject | Nephrectomy | |
dc.subject | Donor | |
dc.subject | Donor nephrectomy | |
dc.subject | Transplantation | |
dc.subject | Chronic kidney disease | |
dc.subject | CKD | |
dc.subject | CKD-EPI | |
dc.subject | ABDOMINAL FAT | |
dc.subject | RISK-FACTORS | |
dc.subject | DISEASE | |
dc.subject | ACCUMULATION | |
dc.subject | ASSOCIATION | |
dc.subject | EXPRESSION | |
dc.subject | JAPANESE | |
dc.type | Article | |
dc.date.updated | 2022-03-13T09:58:43Z | |
dc.contributor.department | SURGERY | |
dc.description.doi | 10.1007/s00345-018-2566-2 | |
dc.description.sourcetitle | WORLD JOURNAL OF UROLOGY | |
dc.description.volume | 37 | |
dc.description.issue | 10 | |
dc.description.page | 2231-2236 | |
dc.published.state | Published | |
Appears in Collections: | Staff Publications Elements |
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Visceral Obesity WJU2018 10.1007_s00345-018-2566-2.pdf | 1.02 MB | Adobe PDF | CLOSED | None |
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