Please use this identifier to cite or link to this item:
https://doi.org/10.1007/s00018-018-2827-7
DC Field | Value | |
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dc.title | Engineering microbes for targeted strikes against human pathogens | |
dc.contributor.author | Hwang, In Young | |
dc.contributor.author | Lee, Hui Ling | |
dc.contributor.author | Huang, James Guoxian | |
dc.contributor.author | Lim, Yvonne Yijuan | |
dc.contributor.author | Yew, Wen Shan | |
dc.contributor.author | Lee, Yung Seng | |
dc.contributor.author | Chang, Matthew Wook | |
dc.date.accessioned | 2022-02-25T01:41:27Z | |
dc.date.available | 2022-02-25T01:41:27Z | |
dc.date.issued | 2018-08-01 | |
dc.identifier.citation | Hwang, In Young, Lee, Hui Ling, Huang, James Guoxian, Lim, Yvonne Yijuan, Yew, Wen Shan, Lee, Yung Seng, Chang, Matthew Wook (2018-08-01). Engineering microbes for targeted strikes against human pathogens. CELLULAR AND MOLECULAR LIFE SCIENCES 75 (15) : 2719-2733. ScholarBank@NUS Repository. https://doi.org/10.1007/s00018-018-2827-7 | |
dc.identifier.issn | 1420682X | |
dc.identifier.issn | 14209071 | |
dc.identifier.uri | https://scholarbank.nus.edu.sg/handle/10635/216136 | |
dc.description.abstract | Lack of pathogen specificity in antimicrobial therapy causes non-discriminant microbial cell killing that disrupts the microflora present. As a result, potentially helpful microbial cells are killed along with the pathogen, altering the biodiversity and dynamic interactions within the population. Moreover, the unwarranted exposure of antibiotics to microbes increases the likelihood of developing resistance and perpetuates the emergence of multidrug resistance. Synthetic biology offers an alternative solution where specificity can be conferred to reduce the non-specific, non-targeted activity of currently available antibiotics, and instead provides targeted therapy against specific pathogens and minimising collateral damage to the host’s inherent microbiota. With a greater understanding of the microbiome and the available genetic engineering tools for microbial cells, it is possible to devise antimicrobial strategies for novel antimicrobial therapy that are able to precisely and selectively remove infectious pathogens. Herein, we review the strategies developed by unlocking some of the natural mechanisms used by the microbes and how these may be utilised in targeted antimicrobial therapy, with the promise of reducing the current global bane of multidrug antimicrobial resistance. | |
dc.language.iso | en | |
dc.publisher | SPRINGER BASEL AG | |
dc.source | Elements | |
dc.subject | Science & Technology | |
dc.subject | Life Sciences & Biomedicine | |
dc.subject | Biochemistry & Molecular Biology | |
dc.subject | Cell Biology | |
dc.subject | Targeted therapy | |
dc.subject | Synthetic biology | |
dc.subject | Infectious pathogen | |
dc.subject | Live biotherapeutics | |
dc.subject | Microbiome | |
dc.subject | Phage engineering | |
dc.subject | Antimicrobial peptide | |
dc.subject | Antibiotic resistance | |
dc.subject | S-TYPE PYOCIN | |
dc.subject | ESCHERICHIA-COLI | |
dc.subject | STAPHYLOCOCCUS-AUREUS | |
dc.subject | BACTERIOPHAGE THERAPY | |
dc.subject | NEXT-GENERATION | |
dc.subject | PHAGE THERAPY | |
dc.subject | INFECTION | |
dc.subject | RESISTANCE | |
dc.subject | PROBIOTICS | |
dc.subject | COCKTAIL | |
dc.type | Review | |
dc.date.updated | 2022-02-24T05:07:50Z | |
dc.contributor.department | BIOCHEMISTRY | |
dc.contributor.department | PAEDIATRICS | |
dc.description.doi | 10.1007/s00018-018-2827-7 | |
dc.description.sourcetitle | CELLULAR AND MOLECULAR LIFE SCIENCES | |
dc.description.volume | 75 | |
dc.description.issue | 15 | |
dc.description.page | 2719-2733 | |
dc.published.state | Published | |
Appears in Collections: | Staff Publications Elements |
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File | Description | Size | Format | Access Settings | Version | |
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Engineering microbes for targeted strikes against human pathogens.pdf | Published version | 1.06 MB | Adobe PDF | CLOSED | None |
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