Please use this identifier to cite or link to this item: https://doi.org/10.3390/mi10100627
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dc.titleAdvancement of peptide nanobiotechnology via emerging microfluidic technology
dc.contributor.authorChan, K.H.
dc.contributor.authorTay, J.J.J.
dc.date.accessioned2022-01-04T06:22:42Z
dc.date.available2022-01-04T06:22:42Z
dc.date.issued2019
dc.identifier.citationChan, K.H., Tay, J.J.J. (2019). Advancement of peptide nanobiotechnology via emerging microfluidic technology. Micromachines 10 (10) : 627. ScholarBank@NUS Repository. https://doi.org/10.3390/mi10100627
dc.identifier.issn2072666X
dc.identifier.urihttps://scholarbank.nus.edu.sg/handle/10635/212927
dc.description.abstractPeptide nanotechnology has experienced a long and enduring development since its inception. Many different applications have been conceptualized, which depends on the functional groups present on the peptide and the physical shape/size of the peptide nanostructures. One of the most prominent nanostructures formed by peptides are nanoparticles. Until recently, however, it has been challenging to engineer peptide nanoparticles with low dispersity. An emerging and promising technique involves the utility of microfluidics to produce a solution of peptide nanoparticles with narrow dispersity. In this process, two or more streams of liquid are focused together to create conditions that are conducive towards the formation of narrowly dispersed samples of peptide nanoparticles. This makes it possible to harness peptide nanoparticles for the myriad of applications that are dependent on nanoparticle size and uniformity. In this focus review, we aim to show how microfluidics may be utilized to (1) study peptide self-assembly, which is critical to controlling nanostructure shape and size, and peptide-interface interactions, and (2) generate self-assembling peptide-based microgels for miniaturized cell cultures. These examples will illustrate how the emerging microfluidic approach promises to revolutionize the production and application of peptide nanoparticles in ever more diverse fields than before. � 2019 by the authors.
dc.publisherMDPI AG
dc.rightsAttribution 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.sourceScopus OA2019
dc.subjectLow dispersity
dc.subjectMicrofluidics
dc.subjectMicrogels
dc.subjectMiniaturized cell cultures
dc.subjectNanoparticles
dc.subjectPeptides
dc.subjectSelf-assembly
dc.typeReview
dc.contributor.departmentCHEMISTRY
dc.description.doi10.3390/mi10100627
dc.description.sourcetitleMicromachines
dc.description.volume10
dc.description.issue10
dc.description.page627
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