Please use this identifier to cite or link to this item: https://doi.org/10.1111/acel.12842
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dc.titleDysregulated homeostatic pathways in sarcopenia among frail older adults
dc.contributor.authorNg, T.P.
dc.contributor.authorLu, Y.
dc.contributor.authorChoo, R.W.M.
dc.contributor.authorTan, C.T.Y.
dc.contributor.authorNyunt, M.S.Z.
dc.contributor.authorGao, Q.
dc.contributor.authorMok, E.W.H.
dc.contributor.authorLarbi, A.
dc.date.accessioned2021-12-29T05:49:22Z
dc.date.available2021-12-29T05:49:22Z
dc.date.issued2018
dc.identifier.citationNg, T.P., Lu, Y., Choo, R.W.M., Tan, C.T.Y., Nyunt, M.S.Z., Gao, Q., Mok, E.W.H., Larbi, A. (2018). Dysregulated homeostatic pathways in sarcopenia among frail older adults. Aging Cell 17 (6) : e12842. ScholarBank@NUS Repository. https://doi.org/10.1111/acel.12842
dc.identifier.issn1474-9718
dc.identifier.urihttps://scholarbank.nus.edu.sg/handle/10635/212528
dc.description.abstractSarcopenia, a core feature of the physical frailty syndrome, is characterized by multisystem physiological dysregulation. No study has explored qualitatively the hierarchical network of relationships among different dysregulated pathways involved in the pathogenesis of sarcopenia. We used 40 blood biomarkers belonging to community-dwelling prefrail and frail older persons to derive measures of multiple physiological pathways, and structural equation modeling to generate path network models of the multisystem physiological dysregulations associated with muscle mass and function (MMF). Insulin–leptin signaling and energy regulation, anabolic sex steroid regulation (testosterone, leptin), and tissue oxygenation (hemoglobin, red cell count) appear to be primary mediating factors exerting direct influences on MMF. There was additionally secondary mediatory involvement of myocyte- and adipocyte-derived cytokines, hypothalamic pituitary adrenal (HPA) stress hormones (cortisol, DHEAS), glomerular function, and immune cell regulatory and inflammatory cytokines and glycoproteins. We conclude that within a hierarchical network of multisystem physiological dysregulations in sarcopenia, dysregulated anabolic and catabolic pathways via sex steroids and insulin–leptin dual signaling and tissue hypoxemia are primary physiological dysregulations responsible for sarcopenia and frailty. © 2018 The Authors. Aging Cell published by the Anatomical Society and John Wiley & Sons Ltd.
dc.publisherBlackwell Publishing Ltd
dc.rightsAttribution 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.sourceScopus OA2018
dc.subjectanemia
dc.subjectblood biomarkers
dc.subjectcortisol
dc.subjectcytokines
dc.subjectDHEAS
dc.subjectglomerular
dc.subjectinflammation
dc.subjectinsulin
dc.subjectleptin
dc.subjectmuscle mass and function
dc.subjecttestosterone
dc.typeArticle
dc.contributor.departmentDEPT OF PSYCHOLOGICAL MEDICINE
dc.description.doi10.1111/acel.12842
dc.description.sourcetitleAging Cell
dc.description.volume17
dc.description.issue6
dc.description.pagee12842
dc.published.statePublished
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