Please use this identifier to cite or link to this item:
https://doi.org/10.1016/j.celrep.2019.07.066
DC Field | Value | |
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dc.title | Hantavirus Inhibits TRAIL-Mediated Killing of Infected Cells by Downregulating Death Receptor 5 | |
dc.contributor.author | Solà-Riera, C. | |
dc.contributor.author | Gupta, S. | |
dc.contributor.author | Maleki, K.T. | |
dc.contributor.author | González-Rodriguez, P. | |
dc.contributor.author | Saidi, D. | |
dc.contributor.author | Zimmer, C.L. | |
dc.contributor.author | Vangeti, S. | |
dc.contributor.author | Rivino, L. | |
dc.contributor.author | Leo, Y.-S. | |
dc.contributor.author | Lye, D.C. | |
dc.contributor.author | MacAry, P.A. | |
dc.contributor.author | Ahlm, C. | |
dc.contributor.author | Smed-Sörensen, A. | |
dc.contributor.author | Joseph, B. | |
dc.contributor.author | Björkström, N.K. | |
dc.contributor.author | Ljunggren, H.-G. | |
dc.contributor.author | Klingström, J. | |
dc.date.accessioned | 2021-12-29T05:43:00Z | |
dc.date.available | 2021-12-29T05:43:00Z | |
dc.date.issued | 2019 | |
dc.identifier.citation | Solà-Riera, C., Gupta, S., Maleki, K.T., González-Rodriguez, P., Saidi, D., Zimmer, C.L., Vangeti, S., Rivino, L., Leo, Y.-S., Lye, D.C., MacAry, P.A., Ahlm, C., Smed-Sörensen, A., Joseph, B., Björkström, N.K., Ljunggren, H.-G., Klingström, J. (2019). Hantavirus Inhibits TRAIL-Mediated Killing of Infected Cells by Downregulating Death Receptor 5. Cell Reports 28 (8) : 2124-2139000000. ScholarBank@NUS Repository. https://doi.org/10.1016/j.celrep.2019.07.066 | |
dc.identifier.issn | 2211-1247 | |
dc.identifier.uri | https://scholarbank.nus.edu.sg/handle/10635/212443 | |
dc.description.abstract | Cytotoxic lymphocytes normally kill virus-infected cells by apoptosis induction. Cytotoxic granule-dependent apoptosis induction engages the intrinsic apoptosis pathway, whereas death receptor (DR)-dependent apoptosis triggers the extrinsic apoptosis pathway. Hantaviruses, single-stranded RNA viruses of the order Bunyavirales, induce strong cytotoxic lymphocyte responses in infected humans. Cytotoxic lymphocytes, however, are largely incapable of eradicating hantavirus-infected cells. Here, we show that the prototypic hantavirus, Hantaan virus (HTNV), induces TRAIL production but strongly inhibits TRAIL-mediated extrinsic apoptosis induction in infected cells by downregulating DR5 cell surface expression. Mechanistic analyses revealed that HTNV triggers both 26S proteasome-dependent degradation of DR5 through direct ubiquitination of DR5 and hampers DR5 transport to the cell surface. These results corroborate earlier findings, demonstrating that hantavirus also inhibits cytotoxic cell granule-dependent apoptosis induction. Together, these findings show that HTNV counteracts intrinsic and extrinsic apoptosis induction pathways, providing a defense mechanism utilized by hantaviruses to inhibit cytotoxic cell-mediated eradication of infected cells. © 2019 The Author(s)Cytotoxic lymphocytes normally kill virus-infected cells by inducing apoptosis. Solà-Riera et al. demonstrate that the RNA virus Hantaan virus efficiently downregulates DR5 cell surface expression by initially triggering a transient 26S proteasome-dependent degradation of DR5 and later hampering DR5 intracellular transport, thus efficiently inhibiting TRAIL-mediated apoptosis of infected cells. © 2019 The Author(s) | |
dc.publisher | Elsevier B.V. | |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 International | |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/4.0/ | |
dc.source | Scopus OA2019 | |
dc.subject | apoptosis | |
dc.subject | death receptor 5 | |
dc.subject | dengue virus | |
dc.subject | hantavirus | |
dc.subject | influenza | |
dc.subject | MG132 | |
dc.subject | orthohantavirus | |
dc.subject | RNA virus | |
dc.subject | TRAIL | |
dc.subject | ubiquitin | |
dc.type | Article | |
dc.contributor.department | LIFE SCIENCES INSTITUTE | |
dc.description.doi | 10.1016/j.celrep.2019.07.066 | |
dc.description.sourcetitle | Cell Reports | |
dc.description.volume | 28 | |
dc.description.issue | 8 | |
dc.description.page | 2124-2139000000 | |
dc.published.state | Published | |
Appears in Collections: | Staff Publications Elements |
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