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dc.titleElectrohydrodynamic jet 3D-printed PCL/PAA conductive scaffolds with tunable biodegradability as nerve guide conduits (NGCs) for peripheral nerve injury repair
dc.contributor.authorVijayavenkataraman, S.
dc.contributor.authorThaharah, S.
dc.contributor.authorZhang, S.
dc.contributor.authorLu, W.F.
dc.contributor.authorFuh, J.Y.H.
dc.identifier.citationVijayavenkataraman, S., Thaharah, S., Zhang, S., Lu, W.F., Fuh, J.Y.H. (2019). Electrohydrodynamic jet 3D-printed PCL/PAA conductive scaffolds with tunable biodegradability as nerve guide conduits (NGCs) for peripheral nerve injury repair. Materials and Design 162 : 171-184. ScholarBank@NUS Repository.
dc.description.abstractNGCs are considered as an alternative treatment method for treating peripheral nerve injuries in place of nerve autografts. Biomimicry, conductivity, and biodegradability are the properties expected of an ideal NGC. PCL/PAA NGCs with three different concentrations of PAA (2.5, 5 and 7.5%) were fabricated using EHD-jet 3D printing. The mechanical properties of the PCL/PAA NGCs mimic the native human nerve properties (ultimate tensile strength of 6.5 to 11.7 MPa) and the conductivity match that of the amphibian motor nerve fiber myelin sheath (10?6 S/cm). The in vitro degradation studies reveal that they are biodegradable and injury/site-specific biodegradability can be obtained by tuning the PCL/PAA concentration ratio. In addition, PAA being a polyanionic polymer has the potential to act as a cation-exchanger, mimicking the functions of the nerve cortical gel layer, thereby influencing the electrophysiological phenomena called nerve excitation and conduction. Neural differentiation studies with PC12 cells assessed by the Reverse Transcription-Polymerase Chain Reaction (RT-PCR) and immunocytochemistry showed enhanced gene expression with the presence of PAA. Our results suggest that the EHD-jet 3D printed porous conductive PCL/PAA NGCs has the potential to be used in the treatment of peripheral nerve injuries. © 2018
dc.publisherElsevier Ltd
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International
dc.sourceScopus OA2019
dc.subject3D printing
dc.subjectConductive scaffolds
dc.subjectElectrohydrodynamic jet
dc.subjectNerve guide conduits
dc.subjectPeripheral nerve injury
dc.subjectTissue engineering scaffolds
dc.contributor.departmentDEPT OF MECHANICAL ENGINEERING
dc.description.sourcetitleMaterials and Design
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