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Please use this identifier to cite or link to this item: https://doi.org/10.1038/s41467-019-13480-z
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dc.titleInsights into malaria susceptibility using genome-wide data on 17,000 individuals from Africa, Asia and Oceania
dc.contributor.authorBand, G.
dc.contributor.authorLe, Q.S.
dc.contributor.authorClarke, G.M.
dc.contributor.authorKivinen, K.
dc.contributor.authorHubbart, C.
dc.contributor.authorJeffreys, A.E.
dc.contributor.authorRowlands, K.
dc.contributor.authorLeffler, E.M.
dc.contributor.authorJallow, M.
dc.contributor.authorConway, D.J.
dc.contributor.authorSisay-Joof, F.
dc.contributor.authorSirugo, G.
dc.contributor.authord’Alessandro, U.
dc.contributor.authorToure, O.B.
dc.contributor.authorThera, M.A.
dc.contributor.authorKonate, S.
dc.contributor.authorSissoko, S.
dc.contributor.authorMangano, V.D.
dc.contributor.authorBougouma, E.C.
dc.contributor.authorSirima, S.B.
dc.contributor.authorAmenga-Etego, L.N.
dc.contributor.authorGhansah, A.K.
dc.contributor.authorHodgson, A.V.O.
dc.contributor.authorWilson, M.D.
dc.contributor.authorEnimil, A.
dc.contributor.authorAnsong, D.
dc.contributor.authorEvans, J.
dc.contributor.authorAdemola, S.A.
dc.contributor.authorApinjoh, T.O.
dc.contributor.authorNdila, C.M.
dc.contributor.authorManjurano, A.
dc.contributor.authorDrakeley, C.
dc.contributor.authorReyburn, H.
dc.contributor.authorPhu, N.H.
dc.contributor.authorQuyen, N.T.N.
dc.contributor.authorThai, C.Q.
dc.contributor.authorHien, T.T.
dc.contributor.authorTeo, Y.Y.
dc.contributor.authorManning, L.
dc.contributor.authorLaman, M.
dc.contributor.authorMichon, P.
dc.contributor.authorKarunajeewa, H.
dc.contributor.authorSiba, P.
dc.contributor.authorAllen, S.
dc.contributor.authorAllen, A.
dc.contributor.authorBahlo, M.
dc.contributor.authorDavis, T.M.E.
dc.contributor.authorSimpson, V.
dc.contributor.authorShelton, J.
dc.contributor.authorSpencer, C.C.A.
dc.contributor.authorBusby, G.B.J.
dc.contributor.authorKerasidou, A.
dc.contributor.authorDrury, E.
dc.contributor.authorStalker, J.
dc.contributor.authorDilthey, A.
dc.contributor.authorMentzer, A.J.
dc.contributor.authorMcVean, G.
dc.contributor.authorBojang, K.A.
dc.contributor.authorDoumbo, O.
dc.contributor.authorModiano, D.
dc.contributor.authorKoram, K.A.
dc.contributor.authorAgbenyega, T.
dc.contributor.authorAmodu, O.K.
dc.contributor.authorAchidi, E.
dc.contributor.authorWilliams, T.N.
dc.contributor.authorMarsh, K.
dc.contributor.authorRiley, E.M.
dc.contributor.authorMolyneux, M.
dc.contributor.authorTaylor, T.
dc.contributor.authorDunstan, S.J.
dc.contributor.authorFarrar, J.
dc.contributor.authorMueller, I.
dc.contributor.authorRockett, K.A.
dc.contributor.authorKwiatkowski, D.P.
dc.contributor.authorMalaria Genomic Epidemiology Network.
dc.date.accessioned2021-12-29T04:06:30Z
dc.date.available2021-12-29T04:06:30Z
dc.date.issued2019
dc.identifier.citationBand, G., Le, Q.S., Clarke, G.M., Kivinen, K., Hubbart, C., Jeffreys, A.E., Rowlands, K., Leffler, E.M., Jallow, M., Conway, D.J., Sisay-Joof, F., Sirugo, G., d’Alessandro, U., Toure, O.B., Thera, M.A., Konate, S., Sissoko, S., Mangano, V.D., Bougouma, E.C., Sirima, S.B., Amenga-Etego, L.N., Ghansah, A.K., Hodgson, A.V.O., Wilson, M.D., Enimil, A., Ansong, D., Evans, J., Ademola, S.A., Apinjoh, T.O., Ndila, C.M., Manjurano, A., Drakeley, C., Reyburn, H., Phu, N.H., Quyen, N.T.N., Thai, C.Q., Hien, T.T., Teo, Y.Y., Manning, L., Laman, M., Michon, P., Karunajeewa, H., Siba, P., Allen, S., Allen, A., Bahlo, M., Davis, T.M.E., Simpson, V., Shelton, J., Spencer, C.C.A., Busby, G.B.J., Kerasidou, A., Drury, E., Stalker, J., Dilthey, A., Mentzer, A.J., McVean, G., Bojang, K.A., Doumbo, O., Modiano, D., Koram, K.A., Agbenyega, T., Amodu, O.K., Achidi, E., Williams, T.N., Marsh, K., Riley, E.M., Molyneux, M., Taylor, T., Dunstan, S.J., Farrar, J., Mueller, I., Rockett, K.A., Kwiatkowski, D.P., Malaria Genomic Epidemiology Network. (2019). Insights into malaria susceptibility using genome-wide data on 17,000 individuals from Africa, Asia and Oceania. Nature Communications 10 (1) : 5732. ScholarBank@NUS Repository. https://doi.org/10.1038/s41467-019-13480-z
dc.identifier.issn20411723
dc.identifier.urihttps://scholarbank.nus.edu.sg/handle/10635/212249
dc.description.abstractThe human genetic factors that affect resistance to infectious disease are poorly understood. Here we report a genome-wide association study in 17,000 severe malaria cases and population controls from 11 countries, informed by sequencing of family trios and by direct typing of candidate loci in an additional 15,000 samples. We identify five replicable associations with genome-wide levels of evidence including a newly implicated variant on chromosome 6. Jointly, these variants account for around one-tenth of the heritability of severe malaria, which we estimate as ~23% using genome-wide genotypes. We interrogate available functional data and discover an erythroid-specific transcription start site underlying the known association in ATP2B4, but are unable to identify a likely causal mechanism at the chromosome 6 locus. Previously reported HLA associations do not replicate in these samples. This large dataset will provide a foundation for further research on thegenetic determinants of malaria resistance in diverse populations. © 2019, The Author(s).
dc.publisherNature Research
dc.rightsAttribution 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.sourceScopus OA2019
dc.typeArticle
dc.contributor.departmentSAW SWEE HOCK SCHOOL OF PUBLIC HEALTH
dc.description.doi10.1038/s41467-019-13480-z
dc.description.sourcetitleNature Communications
dc.description.volume10
dc.description.issue1
dc.description.page5732
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