Please use this identifier to cite or link to this item:
https://doi.org/10.1038/s41467-019-13069-6
DC Field | Value | |
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dc.title | Identification of four novel associations for B-cell acute lymphoblastic leukaemia risk | |
dc.contributor.author | Vijayakrishnan, J. | |
dc.contributor.author | Qian, M. | |
dc.contributor.author | Studd, J.B. | |
dc.contributor.author | Yang, W. | |
dc.contributor.author | Kinnersley, B. | |
dc.contributor.author | Law, P.J. | |
dc.contributor.author | Broderick, P. | |
dc.contributor.author | Raetz, E.A. | |
dc.contributor.author | Allan, J. | |
dc.contributor.author | Pui, C.-H. | |
dc.contributor.author | Vora, A. | |
dc.contributor.author | Evans, W.E. | |
dc.contributor.author | Moorman, A. | |
dc.contributor.author | Yeoh, A. | |
dc.contributor.author | Yang, W. | |
dc.contributor.author | Li, C. | |
dc.contributor.author | Bartram, C.R. | |
dc.contributor.author | Mullighan, C.G. | |
dc.contributor.author | Zimmerman, M. | |
dc.contributor.author | Hunger, S.P. | |
dc.contributor.author | Schrappe, M. | |
dc.contributor.author | Relling, M.V. | |
dc.contributor.author | Stanulla, M. | |
dc.contributor.author | Loh, M.L. | |
dc.contributor.author | Houlston, R.S. | |
dc.contributor.author | Yang, J.J. | |
dc.date.accessioned | 2021-12-29T04:06:26Z | |
dc.date.available | 2021-12-29T04:06:26Z | |
dc.date.issued | 2019 | |
dc.identifier.citation | Vijayakrishnan, J., Qian, M., Studd, J.B., Yang, W., Kinnersley, B., Law, P.J., Broderick, P., Raetz, E.A., Allan, J., Pui, C.-H., Vora, A., Evans, W.E., Moorman, A., Yeoh, A., Yang, W., Li, C., Bartram, C.R., Mullighan, C.G., Zimmerman, M., Hunger, S.P., Schrappe, M., Relling, M.V., Stanulla, M., Loh, M.L., Houlston, R.S., Yang, J.J. (2019). Identification of four novel associations for B-cell acute lymphoblastic leukaemia risk. Nature Communications 10 (1) : 5348. ScholarBank@NUS Repository. https://doi.org/10.1038/s41467-019-13069-6 | |
dc.identifier.issn | 20411723 | |
dc.identifier.uri | https://scholarbank.nus.edu.sg/handle/10635/212248 | |
dc.description.abstract | There is increasing evidence for a strong inherited genetic basis of susceptibility to acute lymphoblastic leukaemia (ALL) in children. To identify new risk variants for B-cell ALL (B-ALL) we conducted a meta-analysis with four GWAS (genome-wide association studies), totalling 5321 cases and 16,666 controls of European descent. We herein describe novel risk loci for B-ALL at 9q21.31 (rs76925697, P = 2.11 × 10?8), for high-hyperdiploid ALL at 5q31.1 (rs886285, P = 1.56 × 10?8) and 6p21.31 (rs210143 in BAK1, P = 2.21 × 10?8), and ETV6-RUNX1 ALL at 17q21.32 (rs10853104 in IGF2BP1, P = 1.82 × 10?8). Particularly notable are the pleiotropic effects of the BAK1 variant on multiple haematological malignancies and specific effects of IGF2BP1 on ETV6-RUNX1 ALL evidenced by both germline and somatic genomic analyses. Integration of GWAS signals with transcriptomic/epigenomic profiling and 3D chromatin interaction data for these leukaemia risk loci suggests deregulation of B-cell development and the cell cycle as central mechanisms governing genetic susceptibility to ALL. © 2019, The Author(s). | |
dc.publisher | Nature Research | |
dc.rights | Attribution 4.0 International | |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | |
dc.source | Scopus OA2019 | |
dc.type | Article | |
dc.contributor.department | PAEDIATRICS | |
dc.description.doi | 10.1038/s41467-019-13069-6 | |
dc.description.sourcetitle | Nature Communications | |
dc.description.volume | 10 | |
dc.description.issue | 1 | |
dc.description.page | 5348 | |
Appears in Collections: | Staff Publications Elements |
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