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Please use this identifier to cite or link to this item: https://doi.org/10.1038/s41467-019-11576-0
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dc.titleGenome-wide association meta-analyses and fine-mapping elucidate pathways influencing albuminuria
dc.contributor.authorTeumer, A.
dc.contributor.authorLi, Y.
dc.contributor.authorGhasemi, S.
dc.contributor.authorPrins, B.P.
dc.contributor.authorWuttke, M.
dc.contributor.authorHermle, T.
dc.contributor.authorGiri, A.
dc.contributor.authorSieber, K.B.
dc.contributor.authorQiu, C.
dc.contributor.authorKirsten, H.
dc.contributor.authorTin, A.
dc.contributor.authorChu, A.Y.
dc.contributor.authorBansal, N.
dc.contributor.authorFeitosa, M.F.
dc.contributor.authorWang, L.
dc.contributor.authorChai, J.-F.
dc.contributor.authorCocca, M.
dc.contributor.authorFuchsberger, C.
dc.contributor.authorGorski, M.
dc.contributor.authorHoppmann, A.
dc.contributor.authorHorn, K.
dc.contributor.authorLi, M.
dc.contributor.authorMarten, J.
dc.contributor.authorNoce, D.
dc.contributor.authorNutile, T.
dc.contributor.authorSedaghat, S.
dc.contributor.authorSveinbjornsson, G.
dc.contributor.authorTayo, B.O.
dc.contributor.authorvan der Most, P.J.
dc.contributor.authorXu, Y.
dc.contributor.authorYu, Z.
dc.contributor.authorGerstner, L.
dc.contributor.authorÄrnlöv, J.
dc.contributor.authorBakker, S.J.L.
dc.contributor.authorBaptista, D.
dc.contributor.authorBiggs, M.L.
dc.contributor.authorBoerwinkle, E.
dc.contributor.authorBrenner, H.
dc.contributor.authorBurkhardt, R.
dc.contributor.authorCarroll, R.J.
dc.contributor.authorChee, M.-L.
dc.contributor.authorChee, M.-L.
dc.contributor.authorChen, M.
dc.contributor.authorCheng, C.-Y.
dc.contributor.authorCook, J.P.
dc.contributor.authorCoresh, J.
dc.contributor.authorCorre, T.
dc.contributor.authorDanesh, J.
dc.contributor.authorde Borst, M.H.
dc.contributor.authorDe Grandi, A.
dc.contributor.authorde Mutsert, R.
dc.contributor.authorde Vries, A.P.J.
dc.contributor.authorDegenhardt, F.
dc.contributor.authorDittrich, K.
dc.contributor.authorDivers, J.
dc.contributor.authorEckardt, K.-U.
dc.contributor.authorEhret, G.
dc.contributor.authorEndlich, K.
dc.contributor.authorFelix, J.F.
dc.contributor.authorFranco, O.H.
dc.contributor.authorFranke, A.
dc.contributor.authorFreedman, B.I.
dc.contributor.authorFreitag-Wolf, S.
dc.contributor.authorGansevoort, R.T.
dc.contributor.authorGiedraitis, V.
dc.contributor.authorGögele, M.
dc.contributor.authorGrundner-Culemann, F.
dc.contributor.authorGudbjartsson, D.F.
dc.contributor.authorGudnason, V.
dc.contributor.authorHamet, P.
dc.contributor.authorHarris, T.B.
dc.contributor.authorHicks, A.A.
dc.contributor.authorHolm, H.
dc.contributor.authorFoo, V.H.X.
dc.contributor.authorHwang, S.-J.
dc.contributor.authorIkram, M.A.
dc.contributor.authorIngelsson, E.
dc.contributor.authorJaddoe, V.W.V.
dc.contributor.authorJakobsdottir, J.
dc.contributor.authorJosyula, N.S.
dc.contributor.authorJung, B.
dc.contributor.authorKähönen, M.
dc.contributor.authorKhor, C.-C.
dc.contributor.authorKiess, W.
dc.contributor.authorKoenig, W.
dc.contributor.authorKörner, A.
dc.contributor.authorKovacs, P.
dc.contributor.authorKramer, H.
dc.contributor.authorKrämer, B.K.
dc.contributor.authorKronenberg, F.
dc.contributor.authorLange, L.A.
dc.contributor.authorLangefeld, C.D.
dc.contributor.authorLee, J.J.-M.
dc.contributor.authorLehtimäki, T.
dc.contributor.authorLieb, W.
dc.contributor.authorLim, S.-C.
dc.contributor.authorLind, L.
dc.contributor.authorLindgren, C.M.
dc.contributor.authorLiu, J.
dc.contributor.authorLoeffler, M.
dc.contributor.authorLyytikäinen, L.-P.
dc.contributor.authorMahajan, A.
dc.contributor.authorMaranville, J.C.
dc.contributor.authorMascalzoni, D.
dc.contributor.authorMcMullen, B.
dc.contributor.authorMeisinger, C.
dc.contributor.authorMeitinger, T.
dc.contributor.authorMiliku, K.
dc.contributor.authorMook-Kanamori, D.O.
dc.contributor.authorMüller-Nurasyid, M.
dc.contributor.authorMychaleckyj, J.C.
dc.contributor.authorNauck, M.
dc.contributor.authorNikus, K.
dc.contributor.authorNing, B.
dc.contributor.authorNoordam, R.
dc.contributor.authorConnell, J.O.
dc.contributor.authorOlafsson, I.
dc.contributor.authorPalmer, N.D.
dc.contributor.authorPeters, A.
dc.contributor.authorPodgornaia, A.I.
dc.contributor.authorPonte, B.
dc.contributor.authorPoulain, T.
dc.contributor.authorPramstaller, P.P.
dc.contributor.authorRabelink, T.J.
dc.contributor.authorRaffield, L.M.
dc.contributor.authorReilly, D.F.
dc.contributor.authorRettig, R.
dc.contributor.authorRheinberger, M.
dc.contributor.authorRice, K.M.
dc.contributor.authorRivadeneira, F.
dc.contributor.authorRunz, H.
dc.contributor.authorRyan, K.A.
dc.contributor.authorSabanayagam, C.
dc.contributor.authorSaum, K.-U.
dc.contributor.authorSchöttker, B.
dc.contributor.authorShaffer, C.M.
dc.contributor.authorShi, Y.
dc.contributor.authorSmith, A.V.
dc.contributor.authorStrauch, K.
dc.contributor.authorStumvoll, M.
dc.contributor.authorSun, B.B.
dc.contributor.authorSzymczak, S.
dc.contributor.authorTai, E.-S.
dc.contributor.authorTan, N.Y.Q.
dc.contributor.authorTaylor, K.D.
dc.contributor.authorTeren, A.
dc.contributor.authorTham, Y.-C.
dc.contributor.authorThiery, J.
dc.contributor.authorThio, C.H.L.
dc.contributor.authorThomsen, H.
dc.contributor.authorThorsteinsdottir, U.
dc.contributor.authorTönjes, A.
dc.contributor.authorTremblay, J.
dc.contributor.authorUitterlinden, A.G.
dc.contributor.authorvan der Harst, P.
dc.contributor.authorVerweij, N.
dc.contributor.authorVogelezang, S.
dc.contributor.authorVölker, U.
dc.contributor.authorWaldenberger, M.
dc.contributor.authorWang, C.
dc.contributor.authorWilson, O.D.
dc.contributor.authorWong, C.
dc.contributor.authorWong, T.-Y.
dc.contributor.authorYang, Q.
dc.contributor.authorYasuda, M.
dc.contributor.authorAkilesh, S.
dc.contributor.authorBochud, M.
dc.contributor.authorBöger, C.A.
dc.contributor.authorDevuyst, O.
dc.contributor.authorEdwards, T.L.
dc.contributor.authorHo, K.
dc.contributor.authorMorris, A.P.
dc.contributor.authorParsa, A.
dc.contributor.authorPendergrass, S.A.
dc.contributor.authorPsaty, B.M.
dc.contributor.authorRotter, J.I.
dc.contributor.authorStefansson, K.
dc.contributor.authorWilson, J.G.
dc.contributor.authorSusztak, K.
dc.contributor.authorSnieder, H.
dc.contributor.authorHeid, I.M.
dc.contributor.authorScholz, M.
dc.contributor.authorButterworth, A.S.
dc.contributor.authorHung, A.M.
dc.contributor.authorPattaro, C.
dc.contributor.authorKöttgen, A.
dc.date.accessioned2021-12-22T09:18:33Z
dc.date.available2021-12-22T09:18:33Z
dc.date.issued2019
dc.identifier.citationTeumer, A., Li, Y., Ghasemi, S., Prins, B.P., Wuttke, M., Hermle, T., Giri, A., Sieber, K.B., Qiu, C., Kirsten, H., Tin, A., Chu, A.Y., Bansal, N., Feitosa, M.F., Wang, L., Chai, J.-F., Cocca, M., Fuchsberger, C., Gorski, M., Hoppmann, A., Horn, K., Li, M., Marten, J., Noce, D., Nutile, T., Sedaghat, S., Sveinbjornsson, G., Tayo, B.O., van der Most, P.J., Xu, Y., Yu, Z., Gerstner, L., Ärnlöv, J., Bakker, S.J.L., Baptista, D., Biggs, M.L., Boerwinkle, E., Brenner, H., Burkhardt, R., Carroll, R.J., Chee, M.-L., Chee, M.-L., Chen, M., Cheng, C.-Y., Cook, J.P., Coresh, J., Corre, T., Danesh, J., de Borst, M.H., De Grandi, A., de Mutsert, R., de Vries, A.P.J., Degenhardt, F., Dittrich, K., Divers, J., Eckardt, K.-U., Ehret, G., Endlich, K., Felix, J.F., Franco, O.H., Franke, A., Freedman, B.I., Freitag-Wolf, S., Gansevoort, R.T., Giedraitis, V., Gögele, M., Grundner-Culemann, F., Gudbjartsson, D.F., Gudnason, V., Hamet, P., Harris, T.B., Hicks, A.A., Holm, H., Foo, V.H.X., Hwang, S.-J., Ikram, M.A., Ingelsson, E., Jaddoe, V.W.V., Jakobsdottir, J., Josyula, N.S., Jung, B., Kähönen, M., Khor, C.-C., Kiess, W., Koenig, W., Körner, A., Kovacs, P., Kramer, H., Krämer, B.K., Kronenberg, F., Lange, L.A., Langefeld, C.D., Lee, J.J.-M., Lehtimäki, T., Lieb, W., Lim, S.-C., Lind, L., Lindgren, C.M., Liu, J., Loeffler, M., Lyytikäinen, L.-P., Mahajan, A., Maranville, J.C., Mascalzoni, D., McMullen, B., Meisinger, C., Meitinger, T., Miliku, K., Mook-Kanamori, D.O., Müller-Nurasyid, M., Mychaleckyj, J.C., Nauck, M., Nikus, K., Ning, B., Noordam, R., Connell, J.O., Olafsson, I., Palmer, N.D., Peters, A., Podgornaia, A.I., Ponte, B., Poulain, T., Pramstaller, P.P., Rabelink, T.J., Raffield, L.M., Reilly, D.F., Rettig, R., Rheinberger, M., Rice, K.M., Rivadeneira, F., Runz, H., Ryan, K.A., Sabanayagam, C., Saum, K.-U., Schöttker, B., Shaffer, C.M., Shi, Y., Smith, A.V., Strauch, K., Stumvoll, M., Sun, B.B., Szymczak, S., Tai, E.-S., Tan, N.Y.Q., Taylor, K.D., Teren, A., Tham, Y.-C., Thiery, J., Thio, C.H.L., Thomsen, H., Thorsteinsdottir, U., Tönjes, A., Tremblay, J., Uitterlinden, A.G., van der Harst, P., Verweij, N., Vogelezang, S., Völker, U., Waldenberger, M., Wang, C., Wilson, O.D., Wong, C., Wong, T.-Y., Yang, Q., Yasuda, M., Akilesh, S., Bochud, M., Böger, C.A., Devuyst, O., Edwards, T.L., Ho, K., Morris, A.P., Parsa, A., Pendergrass, S.A., Psaty, B.M., Rotter, J.I., Stefansson, K., Wilson, J.G., Susztak, K., Snieder, H., Heid, I.M., Scholz, M., Butterworth, A.S., Hung, A.M., Pattaro, C., Köttgen, A. (2019). Genome-wide association meta-analyses and fine-mapping elucidate pathways influencing albuminuria. Nature Communications 10 (1) : 4130. ScholarBank@NUS Repository. https://doi.org/10.1038/s41467-019-11576-0
dc.identifier.issn2041-1723
dc.identifier.urihttps://scholarbank.nus.edu.sg/handle/10635/211660
dc.description.abstractIncreased levels of the urinary albumin-to-creatinine ratio (UACR) are associated with higher risk of kidney disease progression and cardiovascular events, but underlying mechanisms are incompletely understood. Here, we conduct trans-ethnic (n = 564,257) and European-ancestry specific meta-analyses of genome-wide association studies of UACR, including ancestry- and diabetes-specific analyses, and identify 68 UACR-associated loci. Genetic correlation analyses and risk score associations in an independent electronic medical records database (n = 192,868) reveal connections with proteinuria, hyperlipidemia, gout, and hypertension. Fine-mapping and trans-Omics analyses with gene expression in 47 tissues and plasma protein levels implicate genes potentially operating through differential expression in kidney (including TGFB1, MUC1, PRKCI, and OAF), and allow coupling of UACR associations to altered plasma OAF concentrations. Knockdown of OAF and PRKCI orthologs in Drosophila nephrocytes reduces albumin endocytosis. Silencing fly PRKCI further impairs slit diaphragm formation. These results generate a priority list of genes and pathways for translational research to reduce albuminuria. © 2019, The Author(s).
dc.publisherNature Publishing Group
dc.rightsAttribution 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.sourceScopus OA2019
dc.typeArticle
dc.contributor.departmentSAW SWEE HOCK SCHOOL OF PUBLIC HEALTH
dc.contributor.departmentDUKE-NUS MEDICAL SCHOOL
dc.contributor.departmentGENOME INSTITUTE OF SINGAPORE
dc.contributor.departmentMEDICINE
dc.description.doi10.1038/s41467-019-11576-0
dc.description.sourcetitleNature Communications
dc.description.volume10
dc.description.issue1
dc.description.page4130
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