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Title: Filovirus-reactive antibodies in humans and bats in Northeast India imply zoonotic spillover
Authors: Dovih, P.
Laing, E.D.
Chen, Y.
Low, D.H.W. 
Ansil, B.R.
Yang, X.
Shi, Z.
Broder, C.C.
Smith, G.J.D. 
Linster, M. 
Ramakrishnan, U.
Mendenhall, I.H. 
Issue Date: 2019
Publisher: Public Library of Science
Citation: Dovih, P., Laing, E.D., Chen, Y., Low, D.H.W., Ansil, B.R., Yang, X., Shi, Z., Broder, C.C., Smith, G.J.D., Linster, M., Ramakrishnan, U., Mendenhall, I.H. (2019). Filovirus-reactive antibodies in humans and bats in Northeast India imply zoonotic spillover. PLoS Neglected Tropical Diseases 13 (10) : e0007733. ScholarBank@NUS Repository.
Rights: Attribution 4.0 International
Abstract: Bats are reservoirs for several zoonotic pathogens, including filoviruses. Recent work highlights the diversity of bat borne filoviruses in Asia. High risk activities at the bat-human interface pose the threat of zoonotic virus transmission. We present evidence for prior exposure of bat harvesters and two resident fruit bat species to filovirus surface glycoproteins by screening sera in a multiplexed serological assay. Antibodies reactive to two antigenically distinct filoviruses were detected in human sera and to three individual filoviruses in bats in remote Northeast India. Sera obtained from Eonycteris spelaea bats showed similar patterns of cross-reactivity as human samples, suggesting them as the species responsible for the spillover. In contrast, sera from Rousettus leschenaultii bats reacted to two different virus glycoproteins. Our results indicate circulation of several filoviruses in bats and the possibility for filovirus transmission from bats to humans. This is an open access article, free of all copyright, and may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose. The work is made available under the Creative Commons CC0 public domain dedication.
Source Title: PLoS Neglected Tropical Diseases
ISSN: 19352727
DOI: 10.1371/journal.pntd.0007733
Rights: Attribution 4.0 International
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