Please use this identifier to cite or link to this item: https://doi.org/10.1161/JAHA.119.013114
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dc.titleAssociation of Diabetes Mellitus on Cardiac Remodeling, Quality of Life, and Clinical Outcomes in Heart Failure With Reduced and Preserved Ejection Fraction
dc.contributor.authorYap, J.
dc.contributor.authorTay, W.T.
dc.contributor.authorTeng, T.-H.K.
dc.contributor.authorAnand, I.
dc.contributor.authorRichards, A.M.
dc.contributor.authorLing, L.H.
dc.contributor.authorMacDonald, M.R.
dc.contributor.authorChandramouli, C.
dc.contributor.authorTromp, J.
dc.contributor.authorSiswanto, B.B.
dc.contributor.authorZile, M.
dc.contributor.authorMcMurray, J.
dc.contributor.authorLam, C.S.P.
dc.contributor.authorASIAN-HF (Asian Sudden Cardiac Death in Heart Failure) Registry Investigators.
dc.date.accessioned2021-12-16T07:47:27Z
dc.date.available2021-12-16T07:47:27Z
dc.date.issued2019
dc.identifier.citationYap, J., Tay, W.T., Teng, T.-H.K., Anand, I., Richards, A.M., Ling, L.H., MacDonald, M.R., Chandramouli, C., Tromp, J., Siswanto, B.B., Zile, M., McMurray, J., Lam, C.S.P., ASIAN-HF (Asian Sudden Cardiac Death in Heart Failure) Registry Investigators. (2019). Association of Diabetes Mellitus on Cardiac Remodeling, Quality of Life, and Clinical Outcomes in Heart Failure With Reduced and Preserved Ejection Fraction. Journal of the American Heart Association 8 (17) : e013114. ScholarBank@NUS Repository. https://doi.org/10.1161/JAHA.119.013114
dc.identifier.issn20479980
dc.identifier.urihttps://scholarbank.nus.edu.sg/handle/10635/210741
dc.description.abstractBackground Diabetes mellitus frequently coexists with heart failure (HF), but few studies have compared the associations between diabetes mellitus and cardiac remodeling, quality of life, and clinical outcomes, according to HF phenotype. Methods and Results We compared echocardiographic parameters, quality of life (assessed by the Kansas City Cardiomyopathy Questionnaire), and outcomes (1-year all-cause mortality, cardiovascular mortality, and HF hospitalization) between HF patients with and without type 2 diabetes mellitus in the prospective ASIAN-HF (Asian Sudden Cardiac Death in Heart Failure) Registry, as well as community-based controls without HF. Adjusted Cox proportional hazards models were used to assess the association of diabetes mellitus with clinical outcomes. Among 5028 patients with HF and reduced ejection fraction (HFrEF; EF <40%) and 1139 patients with HF and preserved EF (HFpEF; EF ?50%), the prevalences of type 2 diabetes mellitus were 40.2% and 45.0%, respectively (P=0.003). In both HFrEF and HFpEF cohorts, diabetes mellitus (versus no diabetes mellitus) was associated with smaller indexed left ventricular diastolic volumes and higher mitral E/e' ratio. There was a predominance of eccentric hypertrophy in HFrEF and concentric hypertrophy in HFpEF. Patients with diabetes mellitus had lower Kansas City Cardiomyopathy Questionnaire scores in both HFpEF and HFrEF, with more prominent differences in HFpEF (Pinteraction<0.05). In both HFpEF and HFrEF, patients with diabetes mellitus had more HF rehospitalizations (adjusted hazard ratio, 1.27; 95% CI, 1.05-1.54; P=0.014) and higher 1-year rates of the composite of all-cause mortality/HF hospitalization (adjusted hazard ratio, 1.22; 95% CI, 1.05-1.41; P=0.011), with no differences between HF phenotypes (Pinteraction>0.05). Conclusions In HFpEF and HFrEF, type 2 diabetes mellitus is associated with smaller left ventricular volumes, higher mitral E/e' ratio, poorer quality of life, and worse outcomes, with several differences noted between HF phenotypes. Clinical Trial Registration URL: http://www.clinicaltrials.gov. Unique identifier: NCT01633398.
dc.publisherNLM (Medline)
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/
dc.sourceScopus OA2019
dc.subjectdiabetes mellitus
dc.subjectdiabetic cardiomyopathy
dc.subjectechocardiography
dc.subjectheart failure
dc.subjectpreserved left ventricular function
dc.typeArticle
dc.contributor.departmentDUKE-NUS MEDICAL SCHOOL
dc.description.doi10.1161/JAHA.119.013114
dc.description.sourcetitleJournal of the American Heart Association
dc.description.volume8
dc.description.issue17
dc.description.pagee013114
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