Please use this identifier to cite or link to this item: https://doi.org/10.3390/molecules24050995
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dc.titlePleiotropic pharmacological actions of capsazepine, a synthetic analogue of capsaicin, against various cancers and inflammatory diseases
dc.contributor.authorYang, M.H.
dc.contributor.authorJung, S.H.
dc.contributor.authorSethi, G.
dc.contributor.authorAhn, K.S.
dc.date.accessioned2021-12-09T04:57:52Z
dc.date.available2021-12-09T04:57:52Z
dc.date.issued2019
dc.identifier.citationYang, M.H., Jung, S.H., Sethi, G., Ahn, K.S. (2019). Pleiotropic pharmacological actions of capsazepine, a synthetic analogue of capsaicin, against various cancers and inflammatory diseases. Molecules 24 (5) : 995. ScholarBank@NUS Repository. https://doi.org/10.3390/molecules24050995
dc.identifier.issn1420-3049
dc.identifier.urihttps://scholarbank.nus.edu.sg/handle/10635/210059
dc.description.abstractCapsazepine is a synthetic analogue of capsaicin that can function as an antagonist of TRPV1. Capsazepine can exhibit diverse effects on cancer (prostate cancer, breast cancer, colorectal cancer, oral cancer, and osteosarcoma) growth and survival, and can be therapeutically used against other major disorders such as colitis, pancreatitis, malaria, and epilepsy. Capsazepine has been reported to exhibit pleiotropic anti-cancer effects against numerous tumor cell lines. Capsazepine can modulate Janus activated kinase (JAK)/signal transducer and activator of the transcription (STAT) pathway, intracellular Ca2+ concentration, and reactive oxygen species (ROS)-JNK-CCAAT/enhancer-binding protein homologous protein (CHOP) pathways. It can inhibit cell proliferation, metastasis, and induce apoptosis. Moreover, capsazepine can exert anti-inflammatory effects through the downregulation of lipopolysaccharide (LPS)-induced nuclear transcription factor-kappa B (NF-?B), as well as the blockage of activation of both transient receptor potential cation channel subfamily V member 1 (TRPV1) and transient receptor potential cation channel, subfamily A, and member 1 (TRPA1). This review briefly summarizes the diverse pharmacological actions of capsazepine against various cancers and inflammatory conditions. © 2019 by the authors.
dc.publisherMDPI AG
dc.rightsAttribution 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.sourceScopus OA2019
dc.subjectCancer
dc.subjectCapsazepine
dc.subjectInflammatory diseases
dc.subjectROS
dc.subjectTRPV1
dc.typeArticle
dc.contributor.departmentDEPT OF PHARMACOLOGY
dc.description.doi10.3390/molecules24050995
dc.description.sourcetitleMolecules
dc.description.volume24
dc.description.issue5
dc.description.page995
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