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dc.titleClinical features and predictors of severity in COVID-19 patients with critical illness in Singapore.
dc.contributor.authorSer Hon Puah
dc.contributor.authorPuah, Ser Hon
dc.contributor.authorYoung, Barnaby Edward
dc.contributor.authorChia, Po Ying
dc.contributor.authorHo, Vui Kian
dc.contributor.authorLoh, Jiashen
dc.contributor.authorGokhale, Roshni Sadashiv
dc.contributor.authorTan, Seow Yen
dc.contributor.authorSewa, Duu Wen
dc.contributor.authorKalimuddin, Shirin
dc.contributor.authorTan, Chee Keat
dc.contributor.authorPada, Surinder KMS
dc.contributor.authorCove, Matthew Edward
dc.contributor.authorChai, Louis Yi Ann
dc.contributor.authorParthasarathy, Purnima
dc.contributor.authorHo, Benjamin Choon Heng
dc.contributor.authorNg, Jensen Jiansheng
dc.contributor.authorLing, Li Min
dc.contributor.authorAbisheganaden, John A
dc.contributor.authorLee, Vernon JM
dc.contributor.authorTan, Cher Heng
dc.contributor.authorLin, Raymond TP
dc.contributor.authorLeo, Yee Sin
dc.contributor.authorLye, David C
dc.contributor.authorYeo, Tsin Wen
dc.identifier.citationSer Hon Puah, Puah, Ser Hon, Young, Barnaby Edward, Chia, Po Ying, Ho, Vui Kian, Loh, Jiashen, Gokhale, Roshni Sadashiv, Tan, Seow Yen, Sewa, Duu Wen, Kalimuddin, Shirin, Tan, Chee Keat, Pada, Surinder KMS, Cove, Matthew Edward, Chai, Louis Yi Ann, Parthasarathy, Purnima, Ho, Benjamin Choon Heng, Ng, Jensen Jiansheng, Ling, Li Min, Abisheganaden, John A, Lee, Vernon JM, Tan, Cher Heng, Lin, Raymond TP, Leo, Yee Sin, Lye, David C, Yeo, Tsin Wen (2021-04-05). Clinical features and predictors of severity in COVID-19 patients with critical illness in Singapore.. Scientifc Reports 11 (7477). ScholarBank@NUS Repository.
dc.description.abstractWe aim to describe a case series of critically and non-critically ill COVID-19 patients in Singapore. This was a multicentered prospective study with clinical and laboratory details. Details for fifty uncomplicated COVID-19 patients and ten who required mechanical ventilation were collected. We compared clinical features between the groups, assessed predictors of intubation, and described ventilatory management in ICU patients. Ventilated patients were significantly older, reported more dyspnea, had elevated C-reactive protein and lactate dehydrogenase. A multivariable logistic regression model identified respiratory rate (aOR 2.83, 95% CI 1.24–6.47) and neutrophil count (aOR 2.39, 95% CI 1.34–4.26) on admission as independent predictors of intubation with area under receiver operating characteristic curve of 0.928 (95% CI 0.828–0.979). Median APACHE II score was 19 (IQR 17–22) and PaO2/FiO2 ratio before intubation was 104 (IQR 89–129). Median peak FiO2 was 0.75 (IQR 0.6–1.0), positive end-expiratory pressure 12 (IQR 10–14) and plateau pressure 22 (IQR 18–26) in the first 24 h of ventilation. Median duration of ventilation was 6.5 days (IQR 5.5–13). There were no fatalities. Most COVID-19 patients in Singapore who required mechanical ventilation because of ARDS were extubated with no mortality.
dc.subjectScience & Technology
dc.subjectMultidisciplinary Sciences
dc.subjectScience & Technology - Other Topics
dc.subjectILL PATIENTS
dc.contributor.departmentDEAN'S OFFICE (DUKE-NUS MEDICAL SCHOOL)
dc.contributor.departmentDUKE-NUS MEDICAL SCHOOL
dc.contributor.departmentSAW SWEE HOCK SCHOOL OF PUBLIC HEALTH
dc.description.sourcetitleScientifc Reports
Appears in Collections:Staff Publications

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