Please use this identifier to cite or link to this item: https://doi.org/10.1038/s41467-021-25899-4
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dc.titleAnalyses of child cardiometabolic phenotype following assisted reproductive technologies using a pragmatic trial emulation approach
dc.contributor.authorHuang, Jonathan Yinhao
dc.contributor.authorCai, Shirong
dc.contributor.authorHuang, Zhongwei
dc.contributor.authorTint, Mya Thway
dc.contributor.authorYuan, Wen Lun
dc.contributor.authorAris, Izzuddin M
dc.contributor.authorGodfrey, Keith M
dc.contributor.authorKarnani, Neerja
dc.contributor.authorLee, Yung Seng
dc.contributor.authorChan, Jerry Kok Yen
dc.contributor.authorChong, Yap Seng
dc.contributor.authorEriksson, Johan Gunnar
dc.contributor.authorChan, Shiao-Yng
dc.date.accessioned2021-11-29T05:55:26Z
dc.date.available2021-11-29T05:55:26Z
dc.date.issued2021-09-23
dc.identifier.citationHuang, Jonathan Yinhao, Cai, Shirong, Huang, Zhongwei, Tint, Mya Thway, Yuan, Wen Lun, Aris, Izzuddin M, Godfrey, Keith M, Karnani, Neerja, Lee, Yung Seng, Chan, Jerry Kok Yen, Chong, Yap Seng, Eriksson, Johan Gunnar, Chan, Shiao-Yng (2021-09-23). Analyses of child cardiometabolic phenotype following assisted reproductive technologies using a pragmatic trial emulation approach. NATURE COMMUNICATIONS 12 (1). ScholarBank@NUS Repository. https://doi.org/10.1038/s41467-021-25899-4
dc.identifier.issn20411723
dc.identifier.urihttps://scholarbank.nus.edu.sg/handle/10635/208537
dc.description.abstractAssisted reproductive technologies (ART) are increasingly used, however little is known about the long-term health of ART-conceived offspring. Weak selection of comparison groups and poorly characterized mechanisms impede current understanding. In a prospective cohort (Growing Up in Singapore Towards healthy Outcomes; GUSTO; Clinical Trials ID: NCT01174875) including 83 ART-conceived and 1095 spontaneously-conceived singletons, we estimate effects of ART on anthropometry, blood pressure, serum metabolic biomarkers, and cord tissue DNA methylation by emulating a pragmatic trial supported by machine learning-based estimators. We find ART-conceived children to be shorter (−0.5 SD [95% CI: −0.7, −0.2]), lighter (−0.6 SD [−0.9, −0.3]) and have lower skinfold thicknesses (e.g. −14% [−24%, −3%] suprailiac), and blood pressure (−3 mmHg [−6, −0.5] systolic) at 6-6.5 years, with no strong differences in metabolic biomarkers. Differences are not explained by parental anthropometry or comorbidities, polygenic risk score, breastfeeding, or illnesses. Our simulations demonstrate ART is strongly associated with lower NECAB3 DNA methylation, with negative control analyses suggesting these estimates are unbiased. However, methylation changes do not appear to mediate observed differences in child phenotype.
dc.language.isoen
dc.publisherNATURE PORTFOLIO
dc.sourceElements
dc.subjectScience & Technology
dc.subjectMultidisciplinary Sciences
dc.subjectScience & Technology - Other Topics
dc.subjectIN-VITRO FERTILIZATION
dc.subjectDNA METHYLATION
dc.subjectPERINATAL OUTCOMES
dc.subjectUNITED-STATES
dc.subjectASSOCIATION
dc.subjectCONCEPTION
dc.subjectHEALTH
dc.subjectIVF
dc.subjectBORN
dc.subjectEPIGENETICS
dc.typeArticle
dc.date.updated2021-11-28T14:35:48Z
dc.contributor.departmentDEAN'S OFFICE (MEDICINE)
dc.contributor.departmentBIOCHEMISTRY
dc.contributor.departmentOBSTETRICS & GYNAECOLOGY
dc.contributor.departmentPAEDIATRICS
dc.contributor.departmentDUKE-NUS MEDICAL SCHOOL
dc.description.doi10.1038/s41467-021-25899-4
dc.description.sourcetitleNATURE COMMUNICATIONS
dc.description.volume12
dc.description.issue1
dc.published.statePublished
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