Please use this identifier to cite or link to this item: https://doi.org/10.1136/jim-2021-001858
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dc.titleEpidemiological and clinical characteristics of non-severe and severe pediatric and adult COVID-19 patients across different geographical regions in the early phase of pandemic: a systematic review and meta-analysis of observational studies
dc.contributor.authorChua, Pearleen Ee Yong
dc.contributor.authorShah, Shimoni Urvish
dc.contributor.authorGui, Hao
dc.contributor.authorKoh, Jiayun
dc.contributor.authorSomani, Jyoti
dc.contributor.authorPang, Junxiong
dc.date.accessioned2021-11-18T10:18:45Z
dc.date.available2021-11-18T10:18:45Z
dc.date.issued2021-10-01
dc.identifier.citationChua, Pearleen Ee Yong, Shah, Shimoni Urvish, Gui, Hao, Koh, Jiayun, Somani, Jyoti, Pang, Junxiong (2021-10-01). Epidemiological and clinical characteristics of non-severe and severe pediatric and adult COVID-19 patients across different geographical regions in the early phase of pandemic: a systematic review and meta-analysis of observational studies. JOURNAL OF INVESTIGATIVE MEDICINE 69 (7) : 1287-1296. ScholarBank@NUS Repository. https://doi.org/10.1136/jim-2021-001858
dc.identifier.issn10815589
dc.identifier.issn17088267
dc.identifier.urihttps://scholarbank.nus.edu.sg/handle/10635/206711
dc.description.abstractThis systematic and meta-review aimed to compare clinical presentation, outcomes, and care management among patients with COVID-19 during the early phase of the pandemic. A total of 77 peer-reviewed publications were identified between January 1, 2020 and April 9, 2020 from PubMed, Google Scholar, and Chinese Medical Journal databases. Subsequently, meta-analysis of 40 non-overlapping studies, comprising of 4844 patients from seven countries, was conducted to see differences in clinical characteristics and laboratory outcomes across patients from different geographical regions (Wuhan, other parts of China and outside China), severity (non-severe, severe and fatal) and age groups (adults and children). Patients from Wuhan had a higher mean age (54.3 years) and rates of dyspnea (39.5%) compared with patients from other parts of China and outside China. Myalgia, fatigue, acute respiratory distress syndrome (ARDS) and fatalities were also significantly more prevalent among Wuhan patients. A significant dose-response increase in prevalence of diabetes, D-dimer, white blood cells, neutrophil levels and ARDS was seen from non-severe to severe and fatal outcomes. A significant increase in mean duration of symptom onset to admission was seen between non-severe cases (4.2 days) and severe and fatal cases (6.3 days and 8.8 days, respectively). Proportion of asymptomatic cases was higher in children (20%) compared with adults (2.4%). In conclusion, patients with COVID-19 from Wuhan displayed more severe clinical disease during the early phase of the pandemic, while disease severity was significantly lesser among pediatric cases. This review suggests that biomarkers at admission may be useful for prognosis among patients with COVID-19.
dc.language.isoen
dc.publisherBMJ PUBLISHING GROUP
dc.sourceElements
dc.subjectScience & Technology
dc.subjectLife Sciences & Biomedicine
dc.subjectMedicine, General & Internal
dc.subjectMedicine, Research & Experimental
dc.subjectGeneral & Internal Medicine
dc.subjectResearch & Experimental Medicine
dc.subjectCOVID-19
dc.subjectMANIFESTATIONS
dc.subjectWUHAN
dc.typeReview
dc.date.updated2021-11-17T12:22:08Z
dc.contributor.departmentSAW SWEE HOCK SCHOOL OF PUBLIC HEALTH
dc.contributor.departmentMEDICINE
dc.description.doi10.1136/jim-2021-001858
dc.description.sourcetitleJOURNAL OF INVESTIGATIVE MEDICINE
dc.description.volume69
dc.description.issue7
dc.description.page1287-1296
dc.published.statePublished
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