Please use this identifier to cite or link to this item:
https://doi.org/10.1080/14787210.2021.1967145
DC Field | Value | |
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dc.title | Improving empiric antibiotic prescribing in pediatric bloodstream infections: a potential application of weighted-incidence syndromic combination antibiograms (WISCA) | |
dc.contributor.author | Cook, Aislinn | |
dc.contributor.author | Sharland, Mike | |
dc.contributor.author | Yau, Yasmine | |
dc.contributor.author | Bielicki, Julia | |
dc.date.accessioned | 2021-11-17T08:37:18Z | |
dc.date.available | 2021-11-17T08:37:18Z | |
dc.date.issued | 2021-09-12 | |
dc.identifier.citation | Cook, Aislinn, Sharland, Mike, Yau, Yasmine, Bielicki, Julia (2021-09-12). Improving empiric antibiotic prescribing in pediatric bloodstream infections: a potential application of weighted-incidence syndromic combination antibiograms (WISCA). Expert Review of Anti-infective Therapy : 1-12. ScholarBank@NUS Repository. https://doi.org/10.1080/14787210.2021.1967145 | |
dc.identifier.issn | 17448336 | |
dc.identifier.issn | 14787210 | |
dc.identifier.uri | https://scholarbank.nus.edu.sg/handle/10635/206591 | |
dc.description.abstract | Background: Increasing antibiotic resistance to WHO-recommended first- and second-line treatments of pediatric sepsis requires adaptation of prescribing guidelines. We discuss the potential and limitations of a weighted-incidence syndromic combination antibiogram (WISCA) as a practical tool for incorporating local microbiology data when assessing empiric coverage of commonly used antibiotics. Research design and methods: A brief questionnaire of 18 clinically significant isolates from pediatric blood cultures (Jan-Dec 2018) was sent to a global network of pediatric hospitals in July 2019. Weighted coverage estimates of non-antipseudomonal third-generation cephalosporins (3GC) and meropenem were estimated using Monte–Carlo simulation for each site reporting >100 isolates. Results: 52 hospitals in 23 countries in 5 WHO regions responded to the questionnaire; 13 sites met the sample size requirement. The most common isolates were S. aureus, Klebsiella spp., E. coli and Enterococcus spp. Coverage of 3GC ranged from 39% [95%CrI: 34–43%] to 73% (two sites: [95%CrI: 65–80%]; [95%CrI: 68–86%]) and meropenem coverage ranged from 54% [95%CrI: 47–60%] to 88% [95%CrI:84–91%]. Conclusions: A WISCA is a data-driven, clinically intuitive tool that can be used to compare empiric antibiotic regimens for pediatric sepsis using existing large datasets. The estimates can be further refined using more complex meta-analytical methods and patient characteristics. | |
dc.publisher | Informa UK Limited | |
dc.source | Elements | |
dc.subject | Antibiotic resistance | |
dc.subject | pediatric sepsis | |
dc.subject | empiric antibiotic | |
dc.subject | bloodstream infections | |
dc.subject | weighted incidence syndromic combination antibiogram (WISCA) | |
dc.type | Article | |
dc.date.updated | 2021-11-11T02:17:30Z | |
dc.contributor.department | PATHOLOGY | |
dc.description.doi | 10.1080/14787210.2021.1967145 | |
dc.description.sourcetitle | Expert Review of Anti-infective Therapy | |
dc.description.page | 1-12 | |
dc.published.state | Published | |
Appears in Collections: | Staff Publications Elements |
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