Please use this identifier to cite or link to this item: https://doi.org/10.1038/s41598-021-84046-7
DC FieldValue
dc.titleFibrinogen and hemoglobin predict near future cardiovascular events in asymptomatic individuals
dc.contributor.authorLassé, M
dc.contributor.authorPilbrow, AP
dc.contributor.authorKleffmann, T
dc.contributor.authorAndersson Överström, E
dc.contributor.authorvon Zychlinski, A
dc.contributor.authorFrampton, CMA
dc.contributor.authorPoppe, KK
dc.contributor.authorTroughton, RW
dc.contributor.authorLewis, LK
dc.contributor.authorPrickett, TCR
dc.contributor.authorPemberton, CJ
dc.contributor.authorRichards, AM
dc.contributor.authorCameron, VA
dc.date.accessioned2021-11-17T03:29:24Z
dc.date.available2021-11-17T03:29:24Z
dc.date.issued2021-12-01
dc.identifier.citationLassé, M, Pilbrow, AP, Kleffmann, T, Andersson Överström, E, von Zychlinski, A, Frampton, CMA, Poppe, KK, Troughton, RW, Lewis, LK, Prickett, TCR, Pemberton, CJ, Richards, AM, Cameron, VA (2021-12-01). Fibrinogen and hemoglobin predict near future cardiovascular events in asymptomatic individuals. Scientific Reports 11 (1) : 4605-. ScholarBank@NUS Repository. https://doi.org/10.1038/s41598-021-84046-7
dc.identifier.issn20452322
dc.identifier.urihttps://scholarbank.nus.edu.sg/handle/10635/206548
dc.description.abstractTo identify circulating proteins predictive of acute cardiovascular disease events in the general population, we performed a proteomic screen in plasma from asymptomatic individuals. A “Discovery cohort” of 25 individuals who subsequently incurred a cardiovascular event within 3 years (median age = 70 years, 80% male) was matched to 25 controls remaining event-free for > 5 years (median age = 72 years, 80% male). Plasma proteins were assessed by data independent acquisition mass spectrometry (DIA-MS). Associations with cardiovascular events were tested using Cox regression, adjusted for the New Zealand Cardiovascular Risk Score. Concentrations of leading protein candidates were subsequently measured with ELISAs in a larger (n = 151) independent subset. In the Discovery cohort, 76 plasma proteins were robustly quantified by DIA-MS, with 8 independently associated with cardiovascular events. These included (HR = hazard ratio [95% confidence interval] above vs below median): fibrinogen alpha chain (HR = 1.84 [1.19–2.84]); alpha-2-HS-glycoprotein (also called fetuin A) (HR = 1.86 [1.19–2.93]); clusterin isoform 2 (HR = 1.59 [1.06–2.38]); fibrinogen beta chain (HR = 1.55 [1.04–2.30]); hemoglobin subunit beta (HR = 1.49 [1.04–2.15]); complement component C9 (HR = 1.62 [1.01–2.59]), fibronectin isoform 3 (HR = 0.60 [0.37–0.99]); and lipopolysaccharide-binding protein (HR = 1.58 [1.00–2.49]). The proteins for which DIA-MS and ELISA data were correlated, fibrinogen and hemoglobin, were analyzed in an Extended cohort, with broader inclusion criteria and longer time to events, in which these two proteins were not associated with incident cardiovascular events. We have identified eight candidate proteins that may independently predict cardiovascular events occurring within three years in asymptomatic, low-to-moderate risk individuals, although these appear not to predict events beyond three years.
dc.publisherSpringer Science and Business Media LLC
dc.sourceElements
dc.typeArticle
dc.date.updated2021-11-17T02:34:15Z
dc.contributor.departmentMEDICINE
dc.description.doi10.1038/s41598-021-84046-7
dc.description.sourcetitleScientific Reports
dc.description.volume11
dc.description.issue1
dc.description.page4605-
dc.published.stateUnpublished
dc.description.redepositcompleted
Appears in Collections:Staff Publications
Elements

Show simple item record
Files in This Item:
File Description SizeFormatAccess SettingsVersion 
Fibrinogen and hemoglobin predict near future cardiovascular events in asymptomatic individuals.pdfAccepted version879.71 kBAdobe PDF

OPEN

NoneView/Download
Fibrinogen and hemoglobin predict near future cardiovascular events in asymptomatic individuals.pdf879.71 kBAdobe PDF

OPEN

NoneView/Download

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.