Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.jacbts.2019.07.008
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dc.titleSeipin Knockout Mice Develop Heart Failure With Preserved Ejection Fraction
dc.contributor.authorBai, B.
dc.contributor.authorYang, W.
dc.contributor.authorFu, Y.
dc.contributor.authorFoon, H.L.
dc.contributor.authorTay, W.T.
dc.contributor.authorYang, K.
dc.contributor.authorLuo, C.
dc.contributor.authorGunaratne, J.
dc.contributor.authorLee, P.
dc.contributor.authorZile, M.R.
dc.contributor.authorXu, A.
dc.contributor.authorChin, C.W.L.
dc.contributor.authorLam, C.S.P.
dc.contributor.authorHan, W.
dc.contributor.authorWang, Y.
dc.date.accessioned2021-11-16T03:36:41Z
dc.date.available2021-11-16T03:36:41Z
dc.date.issued2019
dc.identifier.citationBai, B., Yang, W., Fu, Y., Foon, H.L., Tay, W.T., Yang, K., Luo, C., Gunaratne, J., Lee, P., Zile, M.R., Xu, A., Chin, C.W.L., Lam, C.S.P., Han, W., Wang, Y. (2019). Seipin Knockout Mice Develop Heart Failure With Preserved Ejection Fraction. JACC: Basic to Translational Science 4 (8) : 924-937. ScholarBank@NUS Repository. https://doi.org/10.1016/j.jacbts.2019.07.008
dc.identifier.issn2452-302X
dc.identifier.urihttps://scholarbank.nus.edu.sg/handle/10635/206261
dc.description.abstractThe lean diabetic patients with heart failure with preserved ejection fraction (HFpEF) in Asia suffer from adverse clinical outcomes and poor life quality. The suitable animal models are urgently needed for mechanistic study and therapeutic innovations. Our study reports that lipodystrophic mice with seipin depletion are lean, diabetic, and recapitulate major manifestations of clinical HFpEF, thereby clarifying that lean diabetes per se may produce HFpEF characteristics. We further demonstrate that increased cardiac titin phosphorylation and reactive interstitial fibrosis associated with neutrophil extracellular traps lead to left ventricular stiffness and suggest that both pathways may be potential therapeutic targets in Asian HFpEF patients. © 2019 The Authors
dc.publisherElsevier Inc
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/
dc.sourceScopus OA2019
dc.subjectfibrosis
dc.subjectheart failure with preserved ejection fraction
dc.subjectneutrophil
dc.subjectseipin
dc.subjecttitin
dc.typeArticle
dc.contributor.departmentDUKE-NUS MEDICAL SCHOOL
dc.description.doi10.1016/j.jacbts.2019.07.008
dc.description.sourcetitleJACC: Basic to Translational Science
dc.description.volume4
dc.description.issue8
dc.description.page924-937
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