Please use this identifier to cite or link to this item:
https://doi.org/10.1084/jem.20180421
DC Field | Value | |
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dc.title | Ca2+- mitochondria axis drives cell division in hematopoietic stem cells | |
dc.contributor.author | Umemoto, Terumasa | |
dc.contributor.author | Hashimoto, Michihiro | |
dc.contributor.author | Matsumura, Takayoshi | |
dc.contributor.author | Nakamura-Ishizu, Ayako | |
dc.contributor.author | Suda, Toshio | |
dc.date.accessioned | 2021-11-15T06:01:49Z | |
dc.date.available | 2021-11-15T06:01:49Z | |
dc.date.issued | 2018-08-01 | |
dc.identifier.citation | Umemoto, Terumasa, Hashimoto, Michihiro, Matsumura, Takayoshi, Nakamura-Ishizu, Ayako, Suda, Toshio (2018-08-01). Ca2+- mitochondria axis drives cell division in hematopoietic stem cells. JOURNAL OF EXPERIMENTAL MEDICINE 215 (8) : 2097-2113. ScholarBank@NUS Repository. https://doi.org/10.1084/jem.20180421 | |
dc.identifier.isbn | 15409538 | |
dc.identifier.issn | 00221007 | |
dc.identifier.uri | https://scholarbank.nus.edu.sg/handle/10635/206157 | |
dc.description.abstract | Most of the hematopoietic stem cells (HSCs) within the bone marrow (BM) show quiescent state with a low mitochondrial membrane potential (ΔΨm). In contrast, upon stress hematopoiesis, HSCs actively start to divide. However, the underlying mechanism for the initiation of HSC division still remains unclear. To elucidate the mechanism underlying the transition of cell cycle state in HSCs, we analyzed the change of mitochondria in HSCs after BM suppression induced by 5-fluoruracil (5-FU). We found that HSCs initiate cell division after exhibiting enhanced ΔΨm as a result of increased intracellular Ca2+ level. Although further activation of Ca2+–mitochondria pathway led to loss of HSCs after cell division, the appropriate suppression of intracellular Ca2+ level by exogenous adenosine or Nifedipine, a Ca2+ channel blocker, prolonged cell division interval in HSCs, and simultaneously achieved both cell division and HSC maintenance. Collectively, our results indicate that the Ca2+–mitochondria pathway induces HSC division critically to determine HSC cell fate. | |
dc.language.iso | en | |
dc.publisher | ROCKEFELLER UNIV PRESS | |
dc.source | Elements | |
dc.subject | Science & Technology | |
dc.subject | Life Sciences & Biomedicine | |
dc.subject | Immunology | |
dc.subject | Medicine, Research & Experimental | |
dc.subject | Research & Experimental Medicine | |
dc.subject | SELF-RENEWAL | |
dc.subject | MAINTENANCE | |
dc.subject | QUIESCENCE | |
dc.subject | CALCIUM | |
dc.subject | RECEPTORS | |
dc.subject | ADENOSINE | |
dc.subject | NICHE | |
dc.subject | DIFFERENTIATION | |
dc.subject | PROLIFERATION | |
dc.subject | HOMEOSTASIS | |
dc.type | Article | |
dc.date.updated | 2021-11-10T02:58:07Z | |
dc.contributor.department | MEDICINE | |
dc.description.doi | 10.1084/jem.20180421 | |
dc.description.sourcetitle | JOURNAL OF EXPERIMENTAL MEDICINE | |
dc.description.volume | 215 | |
dc.description.issue | 8 | |
dc.description.page | 2097-2113 | |
dc.published.state | Published | |
Appears in Collections: | Staff Publications Elements |
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File | Description | Size | Format | Access Settings | Version | |
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Casup2+sup-mitochondria axis drives cell division in hematopoietic stem cells.pdf | 3.96 MB | Adobe PDF | CLOSED | Published |
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