Please use this identifier to cite or link to this item: https://doi.org/10.1186/s12885-020-6664-3
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dc.titleUtility of magnetic resonance imaging in determining treatment response and local recurrence in nasopharyngeal carcinoma treated curatively
dc.contributor.authorMeng, Katherine
dc.contributor.authorTey, Jeremy
dc.contributor.authorHo, Francis Cho Hao
dc.contributor.authorAsim, Hira
dc.contributor.authorCheo, Timothy
dc.date.accessioned2021-11-12T00:47:23Z
dc.date.available2021-11-12T00:47:23Z
dc.date.issued2020-03-06
dc.identifier.citationMeng, Katherine, Tey, Jeremy, Ho, Francis Cho Hao, Asim, Hira, Cheo, Timothy (2020-03-06). Utility of magnetic resonance imaging in determining treatment response and local recurrence in nasopharyngeal carcinoma treated curatively. BMC CANCER 20 (1). ScholarBank@NUS Repository. https://doi.org/10.1186/s12885-020-6664-3
dc.identifier.issn14712407
dc.identifier.issn14712407
dc.identifier.urihttps://scholarbank.nus.edu.sg/handle/10635/206000
dc.description.abstractBackground: To determine the optimal timing of the first Magnetic Resonance Imaging (MRI) scan after curative-intent radiotherapy (RT) for nasopharyngeal carcinoma (NPC), and evaluate the role of MRI in surveillance for locoregional recurrence (LRR). Methods: Patients with non-metastatic NPC treated radically who had at least one post-treatment MRI (ptMRI) done were included for analysis. ptMRI reports were retrospectively reviewed and categorised as complete response (CR), partial response/residual disease (PR) or indeterminate (ID). Patients with LRR were assessed to determine if initial detection was by MRI or clinical means. Univariable and multivariable Cox proportional hazard regression analysis were performed to identify independent factors associated with CR on ptMRIs. Results: Between 2013 and 2017, 262 eligible patients were analysed, all treated with Intensity Modulated Radiotherapy (IMRT). Median time from end of RT to the first ptMRI was 93 days (range 32-346). Of the first ptMRIs, 88 (33.2%) were CR, 133 (50.2%) ID, and 44 (16.6%) PR. A second ptMRI was done for 104 (78.2%) of 133 patients with ID status. In this group, 77 (57.9%) of the subsequent MRI were determined to be CR, 21(15.8%) remained ID and 6 (4.5%) PR. T1 tumour stage and AJCC stage I were associated with increased CR rates on first ptMRI on multivariable analysis. ID status was more likely at 75-105 days (3 months +/- 15 days) vs 106-135 days (4 months +/- 15 days) post RT (OR 2.13, 95% CI 1.16-4.12, p = 0.024). LRR developed in 27 (10.1%) patients; 20 (74.1%) were initially detected through MRI, 3 (11.1%) by nasoendoscopy and 2 (7.4%) by PET-CT. Conclusion: MRI is useful for detecting local recurrence or persistent disease after curative-intent treatment. Most patients will need more than one ptMRI to arrive at a definitive status. The rate of ID ptMRI may be reduced by delaying the first scan to around 4 months post RT.
dc.language.isoen
dc.publisherBMC
dc.sourceElements
dc.subjectScience & Technology
dc.subjectLife Sciences & Biomedicine
dc.subjectOncology
dc.subjectNasopharyngeal carcinoma
dc.subjectNasopharyngeal neoplasms
dc.subjectRadiotherapy
dc.subjectIntensity-modulated radiotherapy
dc.subjectMagnetic resonance imaging
dc.subjectINTENSITY-MODULATED RADIOTHERAPY
dc.subjectFOLLOW-UP
dc.subjectMRI
dc.subjectDIAGNOSIS
dc.subjectCT
dc.subjectPET/CT
dc.subjectHEAD
dc.typeArticle
dc.date.updated2021-11-10T04:14:26Z
dc.contributor.departmentPHYSIOLOGY
dc.description.doi10.1186/s12885-020-6664-3
dc.description.sourcetitleBMC CANCER
dc.description.volume20
dc.description.issue1
dc.published.statePublished
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