Please use this identifier to cite or link to this item: https://doi.org/10.1038/s41467-019-13515-5
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dc.titleASCL1 is a MYCN- and LMO1-dependent member of the adrenergic neuroblastoma core regulatory circuitry
dc.contributor.authorWang, Lu
dc.contributor.authorTan, Tze King
dc.contributor.authorDurbin, Adam D
dc.contributor.authorZimmerman, Mark W
dc.contributor.authorAbraham, Brian J
dc.contributor.authorTan, Shi Hao
dc.contributor.authorNgoc, Phuong Cao Thi
dc.contributor.authorWeichert-Leahey, Nina
dc.contributor.authorAkahane, Koshi
dc.contributor.authorLawton, Lee N
dc.contributor.authorRokita, Jo Lynne
dc.contributor.authorMaris, John M
dc.contributor.authorYoung, Richard A
dc.contributor.authorLook, A Thomas
dc.contributor.authorSanda, Takaomi
dc.date.accessioned2021-11-11T06:46:14Z
dc.date.available2021-11-11T06:46:14Z
dc.date.issued2019-12-09
dc.identifier.citationWang, Lu, Tan, Tze King, Durbin, Adam D, Zimmerman, Mark W, Abraham, Brian J, Tan, Shi Hao, Ngoc, Phuong Cao Thi, Weichert-Leahey, Nina, Akahane, Koshi, Lawton, Lee N, Rokita, Jo Lynne, Maris, John M, Young, Richard A, Look, A Thomas, Sanda, Takaomi (2019-12-09). ASCL1 is a MYCN- and LMO1-dependent member of the adrenergic neuroblastoma core regulatory circuitry. NATURE COMMUNICATIONS 10 (1). ScholarBank@NUS Repository. https://doi.org/10.1038/s41467-019-13515-5
dc.identifier.issn20411723
dc.identifier.urihttps://scholarbank.nus.edu.sg/handle/10635/205902
dc.description.abstractA heritable polymorphism within regulatory sequences of the LMO1 gene is associated with its elevated expression and increased susceptibility to develop neuroblastoma, but the oncogenic pathways downstream of the LMO1 transcriptional co-regulatory protein are unknown. Our ChIP-seq and RNA-seq analyses reveal that a key gene directly regulated by LMO1 and MYCN is ASCL1, which encodes a basic helix-loop-helix transcription factor. Regulatory elements controlling ASCL1 expression are bound by LMO1, MYCN and the transcription factors GATA3, HAND2, PHOX2B, TBX2 and ISL1—all members of the adrenergic (ADRN) neuroblastoma core regulatory circuitry (CRC). ASCL1 is required for neuroblastoma cell growth and arrest of differentiation. ASCL1 and LMO1 directly regulate the expression of CRC genes, indicating that ASCL1 is a member and LMO1 is a coregulator of the ADRN neuroblastoma CRC.
dc.language.isoen
dc.publisherNATURE PUBLISHING GROUP
dc.sourceElements
dc.subjectScience & Technology
dc.subjectMultidisciplinary Sciences
dc.subjectScience & Technology - Other Topics
dc.subjectACHAETE-SCUTE HOMOLOG-1
dc.subjectUP-REGULATION
dc.subjectTAL1 COMPLEX
dc.subjectENHANCER
dc.subjectTRANSCRIPTION
dc.subjectPROTEINS
dc.subjectMUTATION
dc.subjectDRIVES
dc.subjectTARGET
dc.subjectRET
dc.typeArticle
dc.date.updated2021-11-10T03:54:11Z
dc.contributor.departmentCANCER SCIENCE INSTITUTE OF SINGAPORE
dc.contributor.departmentDEPT OF MEDICINE
dc.description.doi10.1038/s41467-019-13515-5
dc.description.sourcetitleNATURE COMMUNICATIONS
dc.description.volume10
dc.description.issue1
dc.published.statePublished
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