DEVELOPMENT OF PHOTO-MEDIATED DECONSTRUCTIVE GEMINAL DEHALOGENATION AND HYDROGEN ATOM TRANSFER CATALYST AND OLEFIN METATHESIS IN FLOW FOR PHARMACEUTICAL SYNTHESIS

Abstract

Deconstructive functionalization of alkenes with photocatalytic reaction is highly attractive but challenging. The combination of flow chemistry with olefin metathesis to synthesize low ruthenium content material is also rarely discussed. Eosin Y which is recently reported for its HAT properties in its neutral is rarely derivatise due to its difficulty in synthesis. In this thesis, a metal-free and catalyst-free photo-mediated oxidative cleavage of olefin to form dihalogenated products is discussed. Subsequently, a simple and up scalable of olefin metathesis in flow reactor is also illustrated for a few precursors for pharmaceutical drugs with low metal contamination using scavenger as a strategy. Lastly, a simple method to synthesize derivative of eosin Y is also discussed and tested for its reactivity in comparison to eosin y for HAT activities.