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Title: | PATHOGENIC ROLE OF CD8+ T CELLS IN MALARIA-ASSOCIATED ACUTE LUNG INJURY IN MICE | Authors: | NGUEE YEE TENG SAMANTHA | ORCID iD: | orcid.org/0000-0001-5381-2377 | Keywords: | Malaria-associated lung injury, CD8, Plasmodium berghei | Issue Date: | 20-Apr-2021 | Citation: | NGUEE YEE TENG SAMANTHA (2021-04-20). PATHOGENIC ROLE OF CD8+ T CELLS IN MALARIA-ASSOCIATED ACUTE LUNG INJURY IN MICE. ScholarBank@NUS Repository. | Abstract: | Malaria-associated lung injury (MA-ALI/ARDS) is a clinical complication of severe malaria. MA-ALI/ARDS is characterized by damaged alveolar-capillary barrier along with marked infiltration of inflammatory cells. However, in MA-ALI/ARDS, the pathogenic mechanisms and their chronology remain largely unclear. In Plasmodium berghei ANKA infected-C57BL/6 mice, we identified CD8+ T cells as the main pathogenic effector in the lung. We demonstrated that with accumulated parasitized erythrocytes in the microvasculature, the activated lung endothelium can cross-present the parasite antigen to parasite-specific CD8+ T cells, a process dependent on IFNγ. We demonstrated that priming of CD8+ T cells required at least CD86-mediated co-stimulation with CD28 in the spleen for its effector functions in the lung to cause injury. In summary, MA-ALI/ARDS is due to the accumulation of parasitized erythrocytes in the lung microvasculature, followed by antigen capture and processing by the activated endothelium, which cross-presents to parasite-specific CD8+ T cells infiltrated in the lung. | URI: | https://scholarbank.nus.edu.sg/handle/10635/204897 |
Appears in Collections: | Ph.D Theses (Open) |
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