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https://doi.org/10.1038/s41598-020-63777-z
DC Field | Value | |
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dc.title | A new non-invasive index for prognosis evaluation in patients with aortic stenosis | |
dc.contributor.author | Sim, H.W. | |
dc.contributor.author | Ngiam, N.J. | |
dc.contributor.author | Zhong, L. | |
dc.contributor.author | Tan, B.Y.-Q. | |
dc.contributor.author | Low, L.Y. | |
dc.contributor.author | Djohan, A.H. | |
dc.contributor.author | Boey, E. | |
dc.contributor.author | Kong, W.K.F. | |
dc.contributor.author | Tan, R.S. | |
dc.contributor.author | Poh, K.K. | |
dc.date.accessioned | 2021-08-25T14:13:44Z | |
dc.date.available | 2021-08-25T14:13:44Z | |
dc.date.issued | 2020 | |
dc.identifier.citation | Sim, H.W., Ngiam, N.J., Zhong, L., Tan, B.Y.-Q., Low, L.Y., Djohan, A.H., Boey, E., Kong, W.K.F., Tan, R.S., Poh, K.K. (2020). A new non-invasive index for prognosis evaluation in patients with aortic stenosis. Scientific Reports 10 (1) : 7333. ScholarBank@NUS Repository. https://doi.org/10.1038/s41598-020-63777-z | |
dc.identifier.issn | 20452322 | |
dc.identifier.uri | https://scholarbank.nus.edu.sg/handle/10635/199350 | |
dc.description.abstract | The global left ventricular (LV) contractility index, d?*/dtmax measures the maximal rate of change in pressure-normalized LV wall stress. We aim to describe the trend of d?*/dtmax in differing severity of aortic stenosis (AS) with preserved left ventricular ejection fraction (LVEF) and the association of d?*/dtmax with clinical outcomes in moderate AS and severe AS. We retrospectively studied a total of 1738 patients with AS (550 mild AS, 738 moderate AS, 450 severe AS) and preserved LVEF ? 50% diagnosed from 1st January 2001 to 31st December 2015. d?*/dtmax worsened with increasing severity of AS despite preserved LVEF (mild AS: 3.69 ± 1.28 s?1, moderate AS: 3.17 ± 1.09 s?1, severe AS: 2.58 ± 0.83 s?1, p < 0.001). Low d?*/dtmax < 2.8 s?1 was independently associated with a higher composite outcome of aortic valve replacement, congestive cardiac failure admissions and all-cause mortality (adjusted hazard ratio 1.48, 95% CI: 1.25–1.77, p < 0.001). In conclusion, d?*/dtmax declined with worsening AS despite preserved LVEF. Low d?*/dtmax < 2.8 s?1 was independently associated with adverse clinical outcomes in moderate AS and severe AS with preserved LVEF. © 2020, The Author(s). | |
dc.publisher | Nature Research | |
dc.rights | Attribution 4.0 International | |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | |
dc.source | Scopus OA2020 | |
dc.type | Article | |
dc.contributor.department | DUKE-NUS MEDICAL SCHOOL | |
dc.contributor.department | MEDICINE | |
dc.description.doi | 10.1038/s41598-020-63777-z | |
dc.description.sourcetitle | Scientific Reports | |
dc.description.volume | 10 | |
dc.description.issue | 1 | |
dc.description.page | 7333 | |
Appears in Collections: | Elements Staff Publications |
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