Please use this identifier to cite or link to this item: https://doi.org/10.1038/s41598-020-73292-w
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dc.titleLactobacillus reuteri DSM 17938 and ATCC PTA 5289 ameliorates chemotherapy-induced oral mucositis
dc.contributor.authorGupta, N.
dc.contributor.authorFerreira, J.
dc.contributor.authorHong, C.H.L.
dc.contributor.authorTan, K.S.
dc.date.accessioned2021-08-25T14:09:54Z
dc.date.available2021-08-25T14:09:54Z
dc.date.issued2020
dc.identifier.citationGupta, N., Ferreira, J., Hong, C.H.L., Tan, K.S. (2020). Lactobacillus reuteri DSM 17938 and ATCC PTA 5289 ameliorates chemotherapy-induced oral mucositis. Scientific Reports 10 (1) : 16189. ScholarBank@NUS Repository. https://doi.org/10.1038/s41598-020-73292-w
dc.identifier.issn20452322
dc.identifier.urihttps://scholarbank.nus.edu.sg/handle/10635/199321
dc.description.abstractOral mucositis (OM) is a common complication of cancer therapy, however OM management remains unsatisfactory. There is a growing interest in the therapeutic potential of probiotics in OM due to positive findings of its use in intestinal mucositis. This study aimed to determine the efficacy and safety of the probiotic combination Lactobacillus reuteri DSM 17938 and ATCC PTA 5289 strains in chemotherapy-induced OM. Mice were divided into 4 groups. PBS/water and PBS/LR groups comprised of mice injected with PBS intraperitoneally (i.p.), and were given water or the mixture of L. reuteri (LR) DSM 17938 and ATCC PTA 5289 in water respectively. The 5-FU/water and 5-FU/LR groups comprised of mice injected with 5-FU i.p., and were given water or L. reuteri DSM 17938 and ATCC PTA 5289 in water respectively. Histopathological analysis revealed that the oral epithelia of the 5-FU/water and 5-FU/LR groups were thinner compared to PBS/water and PBS/LR groups. However, epithelial damage was significantly reduced in the 5-FU/LR compared to 5-FU/water group. Additionally, the 5-FU/LR group showed reduced oxidative stress and inflammation in the oral mucosa. We further showed that L. reuteri reduced oxidative stress through the nuclear factor E2-related factor-2 (Nrf-2) signalling. There was no evidence of translocation of L. reuteri systemically. This study demonstrated for the first time that L. reuteri protected oral mucosa against damage induced by chemotherapy. © 2020, The Author(s).
dc.publisherNature Research
dc.rightsAttribution 4.0 International
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.sourceScopus OA2020
dc.typeArticle
dc.contributor.departmentDENTISTRY
dc.description.doi10.1038/s41598-020-73292-w
dc.description.sourcetitleScientific Reports
dc.description.volume10
dc.description.issue1
dc.description.page16189
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