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dc.titlePreliminary effects of a mobile interactive supervised therapy intervention on people living with HIV: Pilot randomized controlled trial
dc.contributor.authorPang, Y.
dc.contributor.authorMolton, J.S.
dc.contributor.authorOoi, W.T.
dc.contributor.authorPaton, N.I.
dc.contributor.authorHe, H.-G.
dc.identifier.citationPang, Y., Molton, J.S., Ooi, W.T., Paton, N.I., He, H.-G. (2020). Preliminary effects of a mobile interactive supervised therapy intervention on people living with HIV: Pilot randomized controlled trial. JMIR mHealth and uHealth 8 (3) : e15702. ScholarBank@NUS Repository.
dc.description.abstractBackground: As people living with HIV infection require lifelong treatment, nonadherence to medication will reduce their chance of maintaining viral suppression and increase the risk of developing drug resistance and HIV transmission. Objective: This study aimed to evaluate the efficacy of a mobile app, Mobile Interactive Supervised Therapy (MIST), for improving adherence to oral HIV medications among HIV-infected adults in Singapore. Methods: We conducted a two-group pilot randomized controlled trial (RCT) with a process evaluation, in which 40 HIV-infected participants with once-daily medication regimes were recruited from a public tertiary hospital in Singapore and randomly assigned equally to either the intervention (receiving MIST and routine care) or control (receiving routine care only) groups. The intervention lasted for 2 months. The outcome of antiretroviral therapy (ART) adherence was measured by a 7-day recall self-report (SR), pill count (PC), an electronic medical device-Medication Event Monitoring System (MEMS)-and a mobile app-MIST (for the intervention group only). In total, 20 participants from the intervention group were interviewed at the end of the intervention to assess the acceptability of MIST. Data were collected at baseline and at 1-month and 2-month postintervention. Results: All participants had excellent medication adherence at baseline (median 100, IQR 100-100). The use of MIST did not result in a significant improvement in ART adherence when measured by the SR, PC, and MEMS, as compared with the control group at 1-month (P values >.99, .86, and .74, respectively) and 2-month (P values=.80, .84, and .82, respectively) postintervention. ART adherence also did not improve in each group over the same period. MIST was perceived to be a beneficial tool based on the process evaluation results. Conclusions: Although MIST did not enhance medication adherence to HIV treatments, mainly owing to the ceiling effect, it was perceived to be beneficial among the participants of this study. Our process evaluation provided useful data to further develop MIST for bigger and long-term mobile phone app-assisted intervention RCTs in the future. Trial Registration: NCT03794648; © 2020 Journal of Medical Internet Research. All rights reserved.
dc.publisherJMIR Publications Inc.
dc.rightsAttribution 4.0 International
dc.sourceScopus OA2020
dc.subjectAntiretroviral treatment, highly active
dc.subjectHuman immunodeficiency virus
dc.subjectMedication adherence
dc.subjectMobile application
dc.contributor.departmentDEPARTMENT OF COMPUTER SCIENCE
dc.description.sourcetitleJMIR mHealth and uHealth
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