Please use this identifier to cite or link to this item:
https://doi.org/10.1038/s41467-020-19095-z
DC Field | Value | |
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dc.title | Metformin enhances anti-mycobacterial responses by educating CD8+ T-cell immunometabolic circuits | |
dc.contributor.author | Böhme, J. | |
dc.contributor.author | Martinez, N. | |
dc.contributor.author | Li, S. | |
dc.contributor.author | Lee, A. | |
dc.contributor.author | Marzuki, M. | |
dc.contributor.author | Tizazu, A.M. | |
dc.contributor.author | Ackart, D. | |
dc.contributor.author | Frenkel, J.H. | |
dc.contributor.author | Todd, A. | |
dc.contributor.author | Lachmandas, E. | |
dc.contributor.author | Lum, J. | |
dc.contributor.author | Shihui, F. | |
dc.contributor.author | Ng, T.P. | |
dc.contributor.author | Lee, B. | |
dc.contributor.author | Larbi, A. | |
dc.contributor.author | Netea, M.G. | |
dc.contributor.author | Basaraba, R. | |
dc.contributor.author | van Crevel, R. | |
dc.contributor.author | Newell, E. | |
dc.contributor.author | Kornfeld, H. | |
dc.contributor.author | Singhal, A. | |
dc.date.accessioned | 2021-08-24T02:41:40Z | |
dc.date.available | 2021-08-24T02:41:40Z | |
dc.date.issued | 2020 | |
dc.identifier.citation | Böhme, J., Martinez, N., Li, S., Lee, A., Marzuki, M., Tizazu, A.M., Ackart, D., Frenkel, J.H., Todd, A., Lachmandas, E., Lum, J., Shihui, F., Ng, T.P., Lee, B., Larbi, A., Netea, M.G., Basaraba, R., van Crevel, R., Newell, E., Kornfeld, H., Singhal, A. (2020). Metformin enhances anti-mycobacterial responses by educating CD8+ T-cell immunometabolic circuits. Nature Communications 11 (1) : 5225. ScholarBank@NUS Repository. https://doi.org/10.1038/s41467-020-19095-z | |
dc.identifier.issn | 2041-1723 | |
dc.identifier.uri | https://scholarbank.nus.edu.sg/handle/10635/198999 | |
dc.description.abstract | Patients with type 2 diabetes (T2D) have a lower risk of Mycobacterium tuberculosis infection, progression from infection to tuberculosis (TB) disease, TB morality and TB recurrence, when being treated with metformin. However, a detailed mechanistic understanding of these protective effects is lacking. Here, we use mass cytometry to show that metformin treatment expands a population of memory-like antigen-inexperienced CD8+CXCR3+ T cells in naive mice, and in healthy individuals and patients with T2D. Metformin-educated CD8+ T cells have increased (i) mitochondrial mass, oxidative phosphorylation, and fatty acid oxidation; (ii) survival capacity; and (iii) anti-mycobacterial properties. CD8+ T cells from Cxcr3−/− mice do not exhibit this metformin-mediated metabolic programming. In BCG-vaccinated mice and guinea pigs, metformin enhances immunogenicity and protective efficacy against M. tuberculosis challenge. Collectively, these results demonstrate an important function of CD8+ T cells in metformin-derived host metabolic-fitness towards M. tuberculosis infection. © 2020, The Author(s). | |
dc.publisher | Nature Research | |
dc.rights | Attribution 4.0 International | |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | |
dc.source | Scopus OA2020 | |
dc.type | Article | |
dc.contributor.department | PSYCHOLOGICAL MEDICINE | |
dc.description.doi | 10.1038/s41467-020-19095-z | |
dc.description.sourcetitle | Nature Communications | |
dc.description.volume | 11 | |
dc.description.issue | 1 | |
dc.description.page | 5225 | |
dc.published.state | Published | |
Appears in Collections: | Staff Publications Elements |
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