Please use this identifier to cite or link to this item:
https://doi.org/10.1111/1462-2920.15684
DC Field | Value | |
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dc.title | Household environmental microbiota influences early-life eczema development | |
dc.contributor.author | Ta L.D.H. | |
dc.contributor.author | Tay C.J.X. | |
dc.contributor.author | Lay C. | |
dc.contributor.author | de Sessions P.F. | |
dc.contributor.author | Tan C.P.T. | |
dc.contributor.author | Tay M.J.Y. | |
dc.contributor.author | Lau H.X. | |
dc.contributor.author | Zulkifli A.B. | |
dc.contributor.author | Yap G.C. | |
dc.contributor.author | Tham E.H. | |
dc.contributor.author | Ho E.X.P. | |
dc.contributor.author | Goh A.E.N. | |
dc.contributor.author | Godfrey K.M. | |
dc.contributor.author | Eriksson J.G. | |
dc.contributor.author | Knol J. | |
dc.contributor.author | Gluckman P.D. | |
dc.contributor.author | Chong Y.S. | |
dc.contributor.author | Chan J.K.Y. | |
dc.contributor.author | Tan K.H. | |
dc.contributor.author | Chong K.W. | |
dc.contributor.author | Goh S.H. | |
dc.contributor.author | Cheng Z.R. | |
dc.contributor.author | Lee B.W. | |
dc.contributor.author | Shek L.P.-C. | |
dc.contributor.author | Loo E.X.L. | |
dc.date.accessioned | 2021-08-23T09:27:24Z | |
dc.date.available | 2021-08-23T09:27:24Z | |
dc.date.issued | 2021-07-26 | |
dc.identifier.citation | Ta L.D.H., Tay C.J.X., Lay C., de Sessions P.F., Tan C.P.T., Tay M.J.Y., Lau H.X., Zulkifli A.B., Yap G.C., Tham E.H., Ho E.X.P., Goh A.E.N., Godfrey K.M., Eriksson J.G., Knol J., Gluckman P.D., Chong Y.S., Chan J.K.Y., Tan K.H., Chong K.W., Goh S.H., Cheng Z.R., Lee B.W., Shek L.P.-C., Loo E.X.L. (2021-07-26). Household environmental microbiota influences early-life eczema development. Environmental Microbiology. ScholarBank@NUS Repository. https://doi.org/10.1111/1462-2920.15684 | |
dc.identifier.issn | 14622912 | |
dc.identifier.uri | https://scholarbank.nus.edu.sg/handle/10635/198850 | |
dc.description.abstract | Exposure to a diverse microbial environment during pregnancy and early postnatal period is important in determining predisposition towards allergy. However, the effect of environmental microbiota exposure during preconception, pregnancy and postnatal life on development of allergy in the child has not been investigated so far. In the S-PRESTO (Singapore PREconception Study of long Term maternal and child Outcomes) cohort, we collected house dust during all three critical window periods and analysed microbial composition using 16S rRNA gene sequencing. At 6 and 18 months, the child was assessed for eczema by clinicians. In the eczema group, household environmental microbiota was characterized by presence of human-associated bacteria Actinomyces, Anaerococcus, Finegoldia, Micrococcus, Prevotella and Propionibacterium at all time points, suggesting their possible contributions to regulating host immunity and increasing the susceptibility to eczema. In the home environment of the control group, putative protective effect of an environmental microbe Planomicrobium (Planococcaceae family) was observed to be significantly higher than that in the eczema group. Network correlation analysis demonstrated inverse relationships between beneficial Planomicrobium and human-associated bacteria (Actinomyces, Anaerococcus, Finegoldia, Micrococcus, Prevotella and Propionibacterium). Exposure to natural environmental microbiota may be beneficial to modulate shed human-associated microbiota in an indoor environment. © 2021 Society for Applied Microbiology and John Wiley & Sons Ltd. | |
dc.language.iso | en | |
dc.publisher | John Wiley and Sons Inc | |
dc.source | Scopus | |
dc.type | Article | |
dc.contributor.department | OBSTETRICS & GYNAECOLOGY | |
dc.contributor.department | PAEDIATRICS | |
dc.description.doi | 10.1111/1462-2920.15684 | |
dc.description.sourcetitle | Environmental Microbiology | |
dc.description.coden | ENMIF | |
dc.published.state | Published | |
Appears in Collections: | Staff Publications Elements |
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Files in This Item:
File | Description | Size | Format | Access Settings | Version | |
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SPRESTO Dust Manuscript revised EMI clean 210621.pdf | 206.34 kB | Adobe PDF | OPEN | Post-print | View/Download | |
SPRESTO Dust Supplementary Appendix 210621.pdf | 2.06 MB | Adobe PDF | OPEN | Post-print | View/Download | |
SPRESTO Dust Table final revised EMI 160221.pdf | 92.1 kB | Adobe PDF | OPEN | Post-print | View/Download | |
Dust EMI Figure 1 160221.png | 193.75 kB | image/png | OPEN | Post-print | ![]() View/Download | |
Dust EMI Figure 2 160221.png | 590.76 kB | image/png | OPEN | Post-print | ![]() View/Download | |
Dust EMI Figure 3 160221.png | 189.3 kB | image/png | OPEN | Post-print | ![]() View/Download | |
Dust EMI Figure 4 160221.png | 294.25 kB | image/png | OPEN | Post-print | ![]() View/Download | |
EMI Dust Graphical Abstract 160221.jpg | 178.87 kB | JPEG | OPEN | Post-print | ![]() View/Download |
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